DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14731 and R03G8.3

DIOPT Version :9

Sequence 1:	NP_650130.1	Gene:	CG14731 / 41442	FlyBaseID:	FBgn0037964	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_510174.3	Gene:	R03G8.3 / 181437	WormBaseID:	WBGene00010998	Length:	654	Species:	Caenorhabditis elegans

Alignment Length:	688	Identity:	155/688 - (22%)
Similarity:	276/688 - (40%)	Gaps:	126/688 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LILMCIILY-VLINFRE-----QVEHKMKEQPPIEGKPDNKMLFVNS-----SQCQINSMDPFSP 70
            |:..|..:| ||:.|..     ..:..:....||.|...:|::...|     .||::...|.:..
Worm    17 LVTGCFAMYLVLLGFTMFSPLLSPQQYLGLYQPISGNIPSKVVMNKSEVEPWDQCELPQYDIWDD 81

  Fly    71 TAM--YHMTPMPSSACPMIKLMKPQSIDGMNYLYLIASAKELWKKLGVRRLSDIFCAYKRFVRFN 133
            ..:  .:|...|.|.|       .:|.:.:.:|     ....|..  |.:.:.:.|..:...|.:
Worm    82 EILPYLNMEVNPISNC-------NKSREPLTFL-----NNGSWGV--VNKKTKLICRARCHTRKS 132

  Fly   134 DFVNIYFESTLFRFSKLRNFTKVDSGNITLRV---WCWMDYGRLVY---HDVFIFLPFPNPQ-KV 191
            :           |::.:.|:| ...|.|...|   .| .|..:.||   |...|..|...|. ||
Worm   133 E-----------RYNVIGNWT-YTPGPINCEVVEAVC-ADGKKDVYGFLHTQVIATPPKQPTVKV 184

  Fly   192 NNSAPVKRLSVLILGIDSISHMHYQRYFSRVRDLIEGLPHTELWGY-NRVGQNSYPNLIPLLSGQ 255
            :.   :|...|.::.:||:|....:|...|....:.......|:.| |:||.||.||...|..|:
Worm   185 SE---LKNYDVTVIMLDSLSFTQAKRSLLRTISYMTNHMDAVLFPYINKVGDNSRPNGAALWFGK 246

  Fly   256 SVDEVEAK-----------SGCYGASGGTNFDRCHL-------LWHDFQAAGYATIFGEDSRVAG 302
            |:::::..           |..|         .||:       |:.::|..||.|:..|| ...|
Worm   247 SLEKLDRSLFEEENVPVDWSHAY---------MCHVYKDNETSLFKEYQNYGYKTLMAED-WAEG 301

  Fly   303 TFTYVR-PGFKKRPTDFYLRSVINEI------------HMRSTYFARGPLEIKCSGDRVYHHVLY 354
            |..:.. .||.|.|.|..:|...|.:            |:::..:        |..|   ||.|.
Worm   302 TLNWPNCKGFDKPPIDHLMRPFQNALERANHGEPLTKSHLKNQKY--------CRED---HHTLL 355

  Fly   355 DFIYRLLPHMQARMY-DRGFFAFFWQTMGVHDYFQYGERADWEYYRIMRALKRRKILERTLVLIV 418
            |::.:.:     ..| |:..|.:.|.::..||.......:|.::::.:  :|.|:.|:.:.|..:
Worm   356 DYLSQFI-----NAYPDQNKFRWIWASILGHDSENGFPHSDKDFHKFL--IKHREQLDNSFVFFM 413

  Fly   419 SDHGLRYGPFVDTFQGMRETSLPIMVAIYPRSLRERFPLAFANLEANAHRLVTTYDLHETLKDVV 483
            .|||||:|....||.|..:.|.|.:....|::||:...|... :..||.::.|.:|...|:.|::
Worm   414 GDHGLRFGNVRKTFVGTLDVSNPFLAVSIPKNLRQTTGLLNV-MRENAQKIQTHFDTRATMLDIL 477

  Fly   484 DLENLSDERILNRTLRLRNNHNVSLFLPIPE-ERSCFSARIPLHYCQCDGYVKIPWNVRS----- 542
            ..::.|:...|: .|.:......|.....|: .|:|.:..||:.||.|. :.|...:.:|
Worm   478 KYQSASNFTDLD-PLIIPGEKGYSYIRTQPDILRNCRNMPIPMQYCICQ-FNKTQVSTKSETAKG 540

  Fly   543 IQRIAKLAVANINRLLAPYPQCEQLELLNVEDAYLRKQHKLNKTIIVRLV---TQPGNGHFDATV 604
            :.....|||.|.........:|.::::.:|. :.|:...|...:::...|   |:|....:.|.|
Worm   541 VGEAVALAVNNEIEEGKFTDKCVKMKVDHVV-SLLQFDQKFKGSMLYTAVVEMTKPSKAVYKANV 604

  Fly   605 --LSKNETSLQGPITRTDQYRHQSFCAREAPIEIYCYC 640
              |...|..:.|.:.|:::|...::|........||||
Worm   605 KILENGEVKVLGMVERSNKYGSTAYCIGSEHHRPYCYC 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14731	NP_650130.1	DUF229	77..573	CDD:281053	122/541 (23%)
CG14731	NP_650130.1	ALP_like	200..485	CDD:293745	77/317 (24%)
R03G8.3	NP_510174.3	DUF229	92..570	CDD:281053	122/538 (23%)
R03G8.3	NP_510174.3	ALP_like	190..480	CDD:293745	77/318 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D306348at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10974
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.980