DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14731 and Y73F8A.35

DIOPT Version :9

Sequence 1:	NP_650130.1	Gene:	CG14731 / 41442	FlyBaseID:	FBgn0037964	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_001255870.1	Gene:	Y73F8A.35 / 178438	WormBaseID:	WBGene00013539	Length:	654	Species:	Caenorhabditis elegans

Alignment Length:	693	Identity:	161/693 - (23%)
Similarity:	277/693 - (39%)	Gaps:	138/693 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LILMCIILYV-LINFREQVEHKMKEQ-----PPIEGK-PDNKMLFVNS---SQCQINSMDPFSPT 71
            ||:.|.|.|: |:.|...|......|     .||.|| .:|..|.|..   .:|.:...:.::..
Worm    14 LIITCFITYLGLLAFTLLVPAPTSIQYVGVYQPIFGKLEENGSLVVKGDLWDRCDLPDYEIWNDD 78

  Fly    72 AM--YHMTPMPSSACPMIKLMKPQSIDGMNYLYLIASAKELWKKLGVRRLSDIFCAYKRFVRFND 134
            .:  .:|...|.:.|   .:..|.:       |||..:   |..:......|  |..:...|.:|
Worm    79 ILKYLNMDETPITKC---NIAPPLT-------YLINGS---WNAVNASAGYD--CKTRCHWRKDD 128

  Fly   135 FVNIYFESTLFRFSKLRNFTKVDSGNIT--------LRVWCWMD----YGRLVYHDVFIFLPFPN 187
            ..|.                 :.:.|.|        |...|..|    ||.:  |...|..| |.
Worm   129 RTNF-----------------IGNWNSTPGPVDCEFLEAICLKDNLKVYGYM--HSQIIPTP-PI 173

  Fly   188 PQKVNNSAPVKRLSVLILGIDSISHMHYQRYFSRVRDLIEGLPHTELWGY-NRVGQNSYPNLIPL 251
            ..||:.| .:::..|.::.:||::|....|...|....:.......::.| |:||:||..|.:||
Worm   174 TPKVDVS-KLQQYDVTVILLDSLAHAQALRSLPRAISYMTSHMSAVVFPYVNKVGENSRSNGVPL 237

  Fly   252 LSGQSVDEVEAKSGCYGASGGTNFDR------------CH-------LLWHDFQAAGYATIFGED 297
            ..|:|:::::.          :.||.            |:       .::::|:..||.|:..||
Worm   238 WFGKSLEKLDK----------SLFDEEDVTVDWTHEYMCNEFKDNETSIFNEFRDYGYKTLLAED 292

  Fly   298 SRVAGTFTYVR-PGFKKRPTDFYLRSVINEIHM--RSTYFARGPLEIKCSGD--RVYHHVLYDFI 357
             ...||..:.. .||...|.|.|:|...|.:..  ...:..|..|.   .|:  |.:|:.|.:::
Worm   293 -WAEGTLNFPNCKGFDNPPIDHYMRPFQNALERPHHGEFITRNHLS---PGNLTREHHNTLLEYL 353

  Fly   358 YRLLPHMQARMYDRGFFAFFWQTMGVHDYFQYGERADWEYYRIMRALKRRKILERTLVLIVSDHG 422
            .:.   |.|...::. |::.|.:...||.......||.::|..:  :|.|:.|:.:.|:::.|||
Worm   354 SKF---MNAYPNEKK-FSWIWASHLGHDSMNGFSHADNDFYNFL--VKHREKLDNSFVILMGDHG 412

  Fly   423 LRYGPFVDTFQGMRETSLPIMVAIYPRSLRERFPLAFANLEANAHRLVTTYDLHETLKDVVDLE- 486
            .|:|....|..|..|...|.:....|::||:...: .:.::.||.:|.|.||...|:.|::..:
Worm   413 PRFGANRKTVSGELEVHNPFLGISIPKALRKTTEI-LSLMKGNAKKLQTHYDTRATILDILKYQS 476

  Fly   487 --NLSDERILNRTLRLRNNHNVSLFLPIPE-ERSCFSARIPLHYCQCDGYVKIPWNVRSI----- 543
              |..|..|    |::......|.....|: .|:|.:..||:.||.|    |......||
Worm   477 TTNFLDTEI----LKIPGEKGFSFIRKQPDTPRNCKTMPIPIQYCLC----KFNRTTESIHSDLA 533

  Fly   544 QRIAKLAVANINRLLAP---YPQCEQLE---LLNVEDAYLRKQHKLNKTIIVRLVTQ---PGNGH 599
            ..:||...|.:|..|..   ..:|.::|   :|:::    |...|...:|:..:|.:   |.|..
Worm   534 HSMAKALTAAVNTELENGKLQSRCIKMEYSIILSLD----RLDEKFRGSILYTIVVEMKKPSNAW 594

  Fly   600 FDATV--LSKNETSLQGPITRTDQYRHQSFCAREAPIEIYCYC 640
            |.|.:  ||..|..:.|.|.|.::|...:.|.:......||:|
Worm   595 FKANIKMLSTGELKVLGIIERVNEYGQTAHCIKSEYHRPYCFC 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14731	NP_650130.1	DUF229	77..573	CDD:281053	124/547 (23%)
CG14731	NP_650130.1	ALP_like	200..485	CDD:293745	74/309 (24%)
Y73F8A.35	NP_001255870.1	DUF229	89..557	CDD:281053	121/532 (23%)
Y73F8A.35	NP_001255870.1	ALP_like	185..475	CDD:293745	74/310 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10974
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010