Protein Alignment ClC-a and clcB

DIOPT Version :10

• Sequence 1: NP_788639.1
• Gene: ClC-a / 41428
• FlyBaseID: FBgn0051116
• Length: 1193
• Species: Drosophila melanogaster
• Sequence 2: NP_416109.2
• Gene: clcB / 947179
• ECOCYCID: G6850
• Length: 418
• Species: Escherichia coli
• Alignment Length: 479
• Identity: 104/479 - (21%)
• Similarity: 178/479 - (37%)
• Gaps: 97/479 - (20%)

  Fly   161 WRHTVARLGEDWVFLALLGIIMALLSFIMDKG--ISICTNARIWLYRDLTSQPFVQYIAWVSLPV 223
            :||.:..|  :|:||.            .|.|  ::..||...| .|.||  |.:..:|
E. coli    22 FRHAMLLL--EWLFLN------------NDSGSLVNAATNLSPW-RRLLT--PALGGLA------ 63

  Fly   224 CLILFSAGFVHLIAPQSIGSGIPEMKT-ILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLGKEG 287
                  ||.: |:..|......|...| .:..:|......:...:.|.:.....:.||..:|:||
E. coli    64 ------AGLL-LMGWQKFTQQRPHAPTDYMEALQTDGQFDYAASLVKSLASLLVVTSGSAIGREG 121

  Fly   288 PFVHIASIVAQLLSKLVTSFQGIYENESRNSEMLAAAC--AVGVGACFAAPVGGVLFSIEVTTTY 350
            ..:.:|::.|...::..|         .|....|..||  |.|:.|.:.||:.|.||..||....
E. coli   122 AMILLAALAASCFAQRFT---------PRQEWKLWIACGAAAGMAAAYRAPLAGSLFIAEVLFGT 177

  Fly   351 FAVRNYWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLVCGLG 415
            ..:.:......:||....|..|:    .::|.:    |.|.........::..:....|::.||.
E. coli   178 MMLASLGPVIISAVVALLVSNLI----NHSDAL----LYNVQLSVTVQARDYALIISTGVLAGLC 234

  Fly   416 GASYVWVHRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSSISFPLGTGQFLAGELSTHEQVTQ 480
            |...:.:             ||.       .:.||::|.::. .:.|..|..:.|.||
E. coli   235 GPLLLTL-------------MNA-------CHRGFVSLKLAP-PWQLALGGLIVGLLS------- 271

  Fly   481 LFSNFTWSRDDLTVEQAAVVTHWMTSYTSVFGNLVIYTLFTFVVSIIASTIPVPSGMFIPVFKIG 545
            ||:...|.....||:........:.....:|       |......:.:|....|.|:|.|...||
E. coli   272 LFTPAVWGNGYSTVQSFLTAPPLLMIIAGIF-------LCKLCAVLASSGSGAPGGVFTPTLFIG 329

  Fly   546 AGFGRLVGEFMAVTFPHGVRYGGRLSPIMPGGYAVVGAAAFSGSVTHT-VSVAVIIFEMTGQITH 609
            ...|.|.|..:.:.||.|...     .::.|   :.|.|....:.||. :...::|.||||:...
E. coli   330 LAIGMLYGRSLGLWFPDGEEI-----TLLLG---LTGMATLLAATTHAPIMSTLMICEMTGEYQL 386

  Fly   610 VVPVMIAVLVANAVAALL-QPSIY 632
            :..::||.::|:.::..| :.|||
E. coli   387 LPGLLIACVIASVISRTLHRDSIY 410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	101/469 (22%)
		CBS_pair_SF	659..>718	CDD:449531
		CBS repeat	664..715	CDD:341358
		CBS_pair_SF	<1032..1096	CDD:449531
		CBS repeat	1053..1095	CDD:341358
clcB	NP_416109.2	PRK01610	1..418	CDD:234963	104/479 (22%)