Protein Alignment ClC-a and clcA

DIOPT Version :10

• Sequence 1: NP_788639.1
• Gene: ClC-a / 41428
• FlyBaseID: FBgn0051116
• Length: 1193
• Species: Drosophila melanogaster
• Sequence 2: NP_414697.1
• Gene: clcA / 946715
• ECOCYCID: EG12331
• Length: 473
• Species: Escherichia coli
• Alignment Length: 499
• Identity: 117/499 - (23%)
• Similarity: 199/499 - (39%)
• Gaps: 118/499 - (23%)

  Fly   176 ALLGIIMALLSFIMDKGISICTNARIW-LYRDLTSQPFVQYIAWVSLPVCLILFSAGFVHLIAPQ 239
            |::|.::.|.:...|||::...|.|:. |.....:.|.:..:|::...| |.:|....|...||:
E. coli    40 AVVGTLVGLAAVAFDKGVAWLQNQRMGALVHTADNYPLLLTVAFLCSAV-LAMFGYFLVRKYAPE 103

  Fly   240 SIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLGKEGPFVHIASIVAQLLSKLV 304
            :.||||||::..|...:...:  ::.|..|..|...|||.||.||:|||.|.|...:    .::|
E. coli   104 AGGSGIPEIEGALEDQRPVRW--WRVLPVKFFGGLGTLGGGMVLGREGPTVQIGGNI----GRMV 162

  Fly   305 TSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTTTYF--------AVRNYWRGFF 361
            .....:..:|:|:: :||...|.|:.|.|.||:.|:||.||.....|        ||      |.
E. coli   163 LDIFRLKGDEARHT-LLATGAAAGLAAAFNAPLAGILFIIEEMRPQFRYTLISIKAV------FI 220

  Fly   362 AAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLVCGLGGASY-VWV--- 422
            ..:....::|:.     |.:.  ||......::.|.:  .|:::.::|::.|:.|..: .||
E. coli   221 GVIMSTIMYRIF-----NHEV--ALIDVGKLSDAPLN--TLWLYLILGIIFGIFGPIFNKWVLGM 276

  Fly   423 ----HR-------RYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSSISF---PLGT-GQFLAGEL 472
                ||       ::||...:...:...|        ||:|...|...|   |:.| |.|..|.|
E. coli   277 QDLLHRVHGGNITKWVLMGGAIGGLCGLL--------GFVAPATSGGGFNLIPIATAGNFSMGML 333

  Fly   473 STHEQVTQLFSNFTWSRDDLTVEQAAVVTHWMTSYTSVFGNLVIYTLFTFVVSIIASTI----PV 533
                                                          :|.||..:|.:.:    ..
E. coli   334 ----------------------------------------------VFIFVARVITTLLCFSSGA 352

  Fly   534 PSGMFIPVFKIGAGFGRLVGEFMAVTFPHGVRYGGRLSPIMPGGYAVVG-AAAFSGSVTHTVSVA 597
            |.|:|.|:..:|...|...|......||   :|     .:..|.:|:.| .|..:.|:...::..
E. coli   353 PGGIFAPMLALGTVLGTAFGMVAVELFP---QY-----HLEAGTFAIAGMGALLAASIRAPLTGI 409

  Fly   598 VIIFEMTGQITHVVPVMIAVLVANAVAALLQPSIYDSIILIKKL 641
            :::.|||.....::|::|..|.|..:|.........|.||.:.|
E. coli   410 ILVLEMTDNYQLILPMIITGLGATLLAQFTGGKPLYSAILARTL 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	117/499 (23%)
		CBS_pair_SF	659..>718	CDD:449531
		CBS repeat	664..715	CDD:341358
		CBS_pair_SF	<1032..1096	CDD:449531
		CBS repeat	1053..1095	CDD:341358
clcA	NP_414697.1	PRK05277	36..473	CDD:235385	117/499 (23%)