Protein Alignment ClC-a and CLC-E

DIOPT Version :10

• Sequence 1: NP_788639.1
• Gene: ClC-a / 41428
• FlyBaseID: FBgn0051116
• Length: 1193
• Species: Drosophila melanogaster
• Sequence 2: NP_001190924.1
• Gene: CLC-E / 829696
• AraportID: AT4G35440
• Length: 749
• Species: Arabidopsis thaliana
• Alignment Length: 800
• Identity: 164/800 - (20%)
• Similarity: 284/800 - (35%)
• Gaps: 235/800 - (29%)

  Fly   155 RVSSWIWRHTVARLGEDWVFLALL----GIIMALLSFIMDKGISICTNARIWLYRDLTSQPFVQY 215
            |.:||:   ..|.:|.:|:.:.|:    |:::::|:.:.:
plant   112 RGASWL---REAPIGSNWLRVILVPTIGGLVVSILNQLRE------------------------- 148

  Fly   216 IAWVSLPVCLILFSAGFVHLIAPQSIG---SGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATL 277
                         |||       :|.|   |.:..:|.:||..       .||:.|.|     ||
plant   149 -------------SAG-------KSTGDSHSSLDRVKAVLRPF-------LKTVAACV-----TL 181

  Fly   278 GSGMPLGKEGPFVHIASIVAQLLSKLVTSFQGIYENESRNS--EMLAAACAVGVGACFAAPVGGV 340
            |:|..||.|||.|.|.:.:|:.::.|.        |:|..:  .:|||..|.|:.:.|.|.|.|.
plant   182 GTGNSLGPEGPSVEIGASIAKGVNSLF--------NKSPQTGFSLLAAGSAAGISSGFNAAVAGC 238

  Fly   341 LFSIE-------VTTTYFAVRNYWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPF- 397
            .|::|       .|.:..::.|.......:...|:|...:.:..:.|..|         .::.|
plant   239 FFAVESVLWPSSSTDSSTSLPNTTSMVILSAVTASVVSEIGLGSEPAFKV---------PDYDFR 294

  Fly   398 DPQELFVFALIGLVCGLGGASYVWVHRRYVLFMRSN-KRMNKFLQKNRFLYP--GFLALLVSSIS 459
            .|.||.::.|:|.:|||...:.    .|....|.|. ..:||.....:.::|  |.|::.:.::.
plant   295 SPGELPLYLLLGALCGLVSLAL----SRCTSSMTSAVDSLNKDAGIPKAVFPVMGGLSVGIIALV 355

  Fly   460 FPLGTGQFLAGELSTHEQVTQLFSNFTWSRDDLTVEQAAVVTHWMTSYTSVFGNLVIYTLFTFVV 524
            :|              |.:...|.|.     |:.:|:...|.           .|....|...|.
plant   356 YP--------------EVLYWGFQNV-----DILLEKRPFVK-----------GLSADLLLQLVA 390

  Fly   525 SIIASTI-----PVPSGMFIPVFKIGAGFGRLVGEFMAVTFPHGVRYG-GRLSPIMPGGYAVVG- 582
            ..||:|.     .:..|.:.|...||...|...|:|:.:.......:. ..|....|..|.:||
plant   391 VKIAATAWCRASGLVGGYYAPSLFIGGAAGMAYGKFIGLALAQNPDFNLSILEVASPQAYGLVGM 455

  Fly   583 AAAFSGSVTHTVSVAVIIFEMTGQITHVVPVMIAVLVAN-------------------------A 622
            ||..:|.....::..:::||:|.....|:|::.||.:::                         |
plant   456 AATLAGVCQVPLTAVLLLFELTQDYRIVLPLLGAVGMSSWITSGQSKRQETRETKETRKRKSQEA 520

  Fly   623 VAALL---QPSIYDSIILIKKLPYLPDLLPSSSGM-YSIFVEDFMVRDVKYIWHGISYQKLKEVL 683
            |.:|.   ..|..:::..::....|.|.|..|..: .||||.:.|......:....|.::....:
plant   521 VQSLTSSDDESSTNNLCEVESSLCLDDSLNQSEELPKSIFVSEAMRTRFATVMMSTSLEEALTRM 585

  Fly   684 KLNKTLRSLPLVDSPDNMIL----LGSVQRYELIKMIEKHIGREKRMEVAQKWQKEAQERALEEE 744
            .:.|  :|..|:..|||:.|    |..:|.:                   .|.:||...|
plant   586 LIEK--QSCALIVDPDNIFLGILTLSDIQEF-------------------SKARKEGNNR----- 624

  Fly   745 KKKQEVEL---------KMRRPSRFEVLPAPDILSLRQIANDEMLPPKKRAETMHGSL-APRKSI 799
              .:::.:         |.:.|  :.|.|..|:|:.:.|.|...|   .....:.||: |||
plant   625 --PKDIFVNDICSRSGGKCKVP--WTVTPDMDLLAAQTIMNKHEL---SHVAVVSGSIDAPR--- 679

  Fly   800 LKKTNSFNLKTYAQPMGHSPSITPYTTITGNSEFRIRSAFEAIFKKSTTLQ--DVQPDPETGSLS 862
                        ..|:|    :.....||....|......|....|...||  ....:..:.|.|
plant   680 ------------IHPVG----VLDRECITLTRRFPTLDVVEVKLVKKNYLQLFVCSSEERSESQS 728

  Fly   863 PAASNHEVEVPRTPSTPGVS 882
            |.:||..|......|..|::
plant   729 PGSSNQNVPPKFAVSVNGLA 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	106/529 (20%)
		CBS_pair_SF	659..>718	CDD:449531	12/62 (19%)
		CBS repeat	664..715	CDD:341358	10/54 (19%)
		CBS_pair_SF	<1032..1096	CDD:449531
		CBS repeat	1053..1095	CDD:341358
CLC-E	NP_001190924.1	Voltage_gated_ClC	84..494	CDD:238233	106/492 (22%)
		CBS_pair_voltage-gated_CLC_euk_bac	565..692	CDD:341368	31/178 (17%)
		CBS repeat	566..634	CDD:341368	14/95 (15%)
		CBS repeat	645..692	CDD:341368	14/68 (21%)