Protein Alignment ClC-a and Clcnkb

DIOPT Version :10

• Sequence 1: NP_788639.1
• Gene: ClC-a / 41428
• FlyBaseID: FBgn0051116
• Length: 1193
• Species: Drosophila melanogaster
• Sequence 2: NP_775126.1
• Gene: Clcnkb / 79430
• RGDID: 628639
• Length: 687
• Species: Rattus norvegicus
• Alignment Length: 673
• Identity: 257/673 - (38%)
• Similarity: 393/673 - (58%)
• Gaps: 58/673 - (8%)

  Fly   159 WIWRHTVARLGEDWVFLALLGIIMALLSFIMDKGISICTNARIWLYRDLTSQPFVQYIAWVSLPV 223
            |: :..:.|:||||.||..||::|||:|:.|:..|.....|..||||::.....::|::|...||
  Rat    38 WL-KERLFRVGEDWYFLVALGVLMALISYAMNFAIGRVVRAHKWLYREIGDGHLLRYLSWTVYPV 101

  Fly   224 CLILFSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATL--GSGMPLGKE 286
            .|:.||:||...|.|.|.||||||:||||.||.|::||..|...|||:||:.||  ||.:.|||.
  Rat   102 ALLSFSSGFSQSITPSSGGSGIPEVKTILTGVILEDYLDIKNFGAKVVGLSCTLATGSTIFLGKL 166

  Fly   287 GPFVHIASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTTTYF 351
            |||||::.::|..|.::.|...|..||:::..|:|||..||||...||||:.||||||||.:::|
  Rat   167 GPFVHLSVMIAAYLGRVRTKTVGEPENKTKEMELLAAGAAVGVATVFAAPISGVLFSIEVMSSHF 231

  Fly   352 AVRNYWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLVCGLGG 416
            :|.:||||||||.|||.:|.||||:....:|:.:::.|:|..:.|||..|:|.|..:|.:||:..
  Rat   232 SVWDYWRGFFAATCGAFMFHLLAVFNSEQETITSIYKTSFPVDIPFDLPEIFFFVALGAICGILS 296

  Fly   417 ASYVWVHRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSSISFPLGTGQFLAGELSTHEQVTQL 481
            ..|.:..|..:.|::||...:|.|..::.||....|::::||::|.|.|:|:|..||..|.:..|
  Rat   297 CGYNYCQRTSLFFLKSNGFTSKLLATSKPLYSALAAVVLASITYPPGVGRFMASRLSMSEYLETL 361

  Fly   482 FSNFTWSRDDLTVEQAA-----------VVTHWMTSYTSVFGNLVIYTLFTFVVSIIASTIPVPS 535
            |.|.:|:   |..:.::           :...|.....:|||.||.:.:..|.:.|:|:|||:|:
  Rat   362 FDNNSWA---LMTKNSSPPWSAEPDPQNLWLEWCHPQMTVFGTLVFFLVMKFWMLILATTIPIPA 423

  Fly   536 GMFIPVFKIGAGFGRLVGEFMAVTFPHGVRYGGRLSPIMPGGYAVVGAAAFSGSVTHTVSVAVII 600
            |.|:|:|..||..|||.||.:::.||.|:..||::||||||.||:.|||||||:||||:|.|::.
  Rat   424 GYFLPIFVYGAAIGRLFGEVLSLAFPEGIVAGGKVSPIMPGAYALAGAAAFSGAVTHTLSTALLA 488

  Fly   601 FEMTGQITHVVPVMIAVLVANAVAALLQPSIYDSIILIKKLPYLPDLLPSSSGMYSIFVEDFM-- 663
            ||::|||.|.:||::|||.|||:....|||.||..|::|||||||.:.....|.:.:.|..||
  Rat   489 FEVSGQIVHALPVLMAVLAANAICQSYQPSFYDGTIIVKKLPYLPWIRGRKIGSHLVTVGHFMNC 553

  Fly   664 -----VRDVKYIWHGISYQKLKEVLK--LNKTLRSLPLVDSPDNMILLGSVQRYELIKMIEKHIG 721
                 .:|:          .|:||:|  ::..:...|||::.::.:|:|.|:|..|::.:...
  Rat   554 TLTTLAKDM----------PLEEVIKVVISTDVTQYPLVETTESQVLVGIVKRTHLVQSLHTD-- 606

  Fly   722 REKRMEVAQKW---QKEAQERALEEEKKKQEVELKM-RRPSRFEVLPAPDILSL---------RQ 773
                   :..|   |:...:..|......|.|.|:: ...|..|.....::|:|         |.
  Rat   607 -------SASWAPGQQPCLQDILANGCPTQPVTLQLSTETSLHETHNLFELLNLQLLFVTSRGRA 664

  Fly   774 IANDEMLPPKKRAETMHGSLAPR 796
            :.:...:..||...|:....||:
  Rat   665 VGSVSWVELKKAISTLTNPPAPK 687

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	219/487 (45%)
		CBS_pair_SF	659..>718	CDD:449531	16/67 (24%)
		CBS repeat	664..715	CDD:341358	13/52 (25%)
		CBS_pair_SF	<1032..1096	CDD:449531
		CBS repeat	1053..1095	CDD:341358
Clcnkb	NP_775126.1	ClC_1_like	49..533	CDD:239655	218/486 (45%)
		CBS_pair_voltage-gated_CLC_euk_bac	546..676	CDD:341367	28/148 (19%)
		CBS repeat	552..627	CDD:341367	16/93 (17%)
		CBS repeat	633..675	CDD:341367	6/41 (15%)