Protein Alignment ClC-a and clcn1b

DIOPT Version :10

• Sequence 1: NP_788639.1
• Gene: ClC-a / 41428
• FlyBaseID: FBgn0051116
• Length: 1193
• Species: Drosophila melanogaster
• Sequence 2: XP_073782103.1
• Gene: clcn1b / 567478
• ZFINID: ZDB-GENE-100921-11
• Length: 958
• Species: Danio rerio
• Alignment Length: 1156
• Identity: 412/1156 - (35%)
• Similarity: 597/1156 - (51%)
• Gaps: 270/1156 - (23%)

  Fly    99 DPIGYIDT-------LMYGRYTKDLGEFAKDEARKLKILEKRRKQEDKQR--------------- 141
            :||...:|       |:||.|.:.||..::.||.:|...::.::..|..:
Zfish     4 EPINTFETVLNFDQVLLYGEYREQLGNISRREATRLLTEKQWKRHADNSKATRRGHGRAHHASLD 68

  Fly   142 ----------NKELLGKHS-TRAKRVSSWIWRHTVARLGEDWVFLALLGIIMALLSFIMDKGISI 195
                      :..|:..|. .:.:...:.:.|:.|.:|||||:||.|||:.|||:|:.||...:.
Zfish    69 VGPLTPGLSPSSSLIKSHPYFKCQDCLARVQRYIVTKLGEDWIFLVLLGLTMALVSWSMDYASAK 133

  Fly   196 CTNARIWLYRDLTSQPFVQYIAWVSLPVCLILFSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEY 260
            ...|..|:|.:|.....:||:||||.|:.|::|::.|.||:|||:|||||||:|||||||.||||
Zfish   134 SIQAYKWMYGELKGNVALQYLAWVSYPIILVVFASLFCHLVAPQAIGSGIPELKTILRGVVLKEY 198

  Fly   261 LTFKTLVAKVIGLTATLGSGMPLGKEGPFVHIASIVAQLLSKLVTSFQGIYENESRNSEMLAAAC 325
            ||.|..|||||||||.||||||:||||||||||||.|.:||::::.|.|:|||....:::|...|
Zfish   199 LTLKAFVAKVIGLTAGLGSGMPIGKEGPFVHIASICAAVLSRVMSIFTGVYENPYGYTDILTVGC 263

  Fly   326 AVGVGACFAAPVGGVLFSIEVTTTYFAVRNYWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTN 390
            |||||.||..|:||||||||||:|||||||||||:|||...|.:||:|:||.:::.|:.|||.||
Zfish   264 AVGVGCCFGTPLGGVLFSIEVTSTYFAVRNYWRGYFAATFSAFIFRVLSVWNKDSVTITALFRTN 328

  Fly   391 FTTEFPFDPQELFVFALIGLVCGLGGASYVWVHRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLV 455
            |..:||||.|||..||:||:.||..||.:|:::|:.||.||....:.:||.|:|.:|||.:.|::
Zfish   329 FRMDFPFDLQELPAFAIIGISCGFLGAFFVYLNRQVVLIMRRPTALTRFLTKHRLIYPGAVTLII 393

  Fly   456 SSISFPLGTGQFLAGELSTHEQVTQLFSNFTWSR-------DDLTVEQAAVVTHWMTSYTSVFGN 513
            :|.:||.|.|||:||||...|.:..||.|:||::       ..|....|     |:....|||..
Zfish   394 ASFTFPPGFGQFMAGELMPRECINSLFDNYTWTKIWGSPVPPGLGRSAA-----WLHPQVSVFVI 453

  Fly   514 LVIYTLFTFVVSIIASTIPVPSGMFIPVFKIGAGFGRLVGEFMAVTFPHGVRYGGRLSPIMPGGY 578
            |:::.:..|.:|.:::|:|||||.|:|||.:||.|||||||.||..||:|:.:.|.:..|:||||
Zfish   454 LLLFFVMKFWMSAVSTTMPVPSGAFMPVFILGAAFGRLVGEIMATLFPNGILFDGIVYQILPGGY 518

  Fly   579 AVVGAAAFSGSVTHTVSVAVIIFEMTGQITHVVPVMIAVLVANAVAALLQPSIYDSIILIKKLPY 643
            ||:||||.:|:||||||.|||.||:||||:|::|:|:||::||.||..||||:|||||.:|||||
Zfish   519 AVIGAAAMTGAVTHTVSTAVICFELTGQISHILPMMVAVILANMVAQGLQPSLYDSIIQVKKLPY 583

  Fly   644 LPDLLPSSSGMYSIFVEDFMVRDVKYIWHGISYQKLKEVLKLNKTLRSLPLVDSPDNMILLGSVQ 708
            ||:|.......|:|||||.||:.:|::....:|::||::|: :.:|:::||:||.|.||||||::
Zfish   584 LPELGIGHISKYNIFVEDIMVKKIKFLSPQSTYRELKDLLE-STSLKTIPLIDSKDTMILLGSIE 647

  Fly   709 RYELIKMIEKHIGREKRMEVAQKWQKEAQERALEEEKKKQEVELKMRRPSRFEVLPAPDILSLRQ 773
            |.||              :.|..|...|:.|..    .:.|....:.....:|.....|    .:
Zfish   648 RCEL--------------QAALDWWLSAERRVY----NRGEGMASLVSEGSWESFVFVD----EE 690

  Fly   774 IANDEMLPPKKRAETMHGSLAPRKSILKKTNSFNLKTYAQPMGHSPSITPYTTITGNSEFR-IRS 837
            :..:......:.:|..:|                      |:|.|.:....|..|.:...: :|.
Zfish   691 VGEENRDKGNRVSEECNG----------------------PVGSSKTTDISTNHTTSGALKSMRR 733

  Fly   838 AFEAIFKKSTTLQDVQPDPETGSLSPAASNHEVEVPRTPSTPGVSKKVQLPAQSNWDFVTDQIML 902
            .|:.:|..|::  ..|..||...||||..      .::|:.|.|
Zfish   734 TFQRLFSSSSS--SGQTKPEFTKLSPAGG------VKSPAAPPV--------------------- 769

  Fly   903 QVNPISTESNKMPAEKDFTDKALSNNGDSSKQSPSIKFKANKVADVNRSPQTAKRCSKIRFANEV 967
                                                                             
Zfish   770 ----------------------------------------------------------------- 769

  Fly   968 GVNGSPTRTKCKIKPENVLGYSIEDVDETTNPESLAESIQKPKSVRLPRERVIDMSPEDQKQWEL 1032
                                                               |.:|:||:.|.||.
Zfish   770 ---------------------------------------------------VDNMTPEEIKAWEE 783

  Fly  1033 EEMLKPIDLQKANVHIDPSPFQLVERTSILKVHSLFSMVGINHAYVTKIGRLVGVVGLKELRKAI 1097
            :|:.|||.:.:  :.:||||||||||||:.|.|:|||::|::|||||.||:|||||.||||:|||
Zfish   784 KELDKPIGIDQ--IRVDPSPFQLVERTSLHKTHTLFSLLGLSHAYVTSIGKLVGVVALKELQKAI 846

  Fly  1098 EDINSNSFV---PPT---RDEDADEKPAVEKPLLSTN---------------SSDKAVDMTVTSM 1141
            |. ::.|.|   ||.   ||.....|.....|.:.::               |.:::....:.::
Zfish   847 EG-STRSGVRLRPPLASFRDARRKTKKPSHSPSIPSSPTQDIELWSEAVRRESKEESAGSCIQTV 910

  Fly  1142 DSALSNSENCSDIEMEHIKHTDKGTVSLTMPPQESKQSP----SADKSNTE 1188
            :....:|.|......|.:..      |.|:|.......|    .|:|...|
Zfish   911 EKECESSRNIVSTSEEQLPS------SSTVPLSSLHSVPGGEGDAEKERDE 955

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	266/481 (55%)
		CBS_pair_SF	659..>718	CDD:449531	25/58 (43%)
		CBS repeat	664..715	CDD:341358	21/50 (42%)
		CBS_pair_SF	<1032..1096	CDD:449531	38/63 (60%)
		CBS repeat	1053..1095	CDD:341358	30/41 (73%)
clcn1b	XP_073782103.1	None