Protein Alignment ClC-a and clcn5a

DIOPT Version :10

• Sequence 1: NP_788639.1
• Gene: ClC-a / 41428
• FlyBaseID: FBgn0051116
• Length: 1193
• Species: Drosophila melanogaster
• Sequence 2: XP_001920783.2
• Gene: clcn5a / 562336
• ZFINID: ZDB-GENE-091113-15
• Length: 811
• Species: Danio rerio
• Alignment Length: 747
• Identity: 212/747 - (28%)
• Similarity: 339/747 - (45%)
• Gaps: 160/747 - (21%)

  Fly    91 DSDSSDDDDPI--GYIDTLMYGRYTKDLGEFAKDEARKLKILEK-----------------RRKQ 136
            |..|:||..|:  .|...:.||     .||......:.:.:|::                 |.|.
Zfish    32 DFSSTDDVPPLDRDYGSGVSYG-----AGEGPNGIPKLMDLLDEPVPGVGTYEDFNTIDWVREKS 91

  Fly   137 EDKQRNKELLGKHSTRAKRVSSWIWRHTVARLGEDWVFLALLGIIMALLS--------FIMDKGI 193
            :|:.|::|:..|     .:.|:|.....::.....|:.:.|:|::...|:        ::.|...
Zfish    92 KDRDRHREIAIK-----SKESTWALLKRISDAFSGWLLMLLVGLMSGALAGGIDISAHWMTDLKE 151

  Fly   194 SICTNA--------------------------RIW--LYRDLTSQPF---VQYIAWVSLPVCLIL 227
            .:|.|.                          :.|  |.....|.||   :.|:.:||..:....
Zfish   152 GVCLNGFWFNHEHCCWNSNETTFQERDKCPKWKSWAELIVGTNSGPFAYIMNYLMYVSWALLFSF 216

  Fly   228 FSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLGKEGPFVHI 292
            .:...|...||.:.||||||:||||.|..::.||...||:.|.|.|...:.||:.||||||.||:
Zfish   217 LAVSLVRAFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVSSGLSLGKEGPLVHV 281

  Fly   293 ASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTTTYFAVRNYW 357
            |...|.:|..|.|.::   .||::..|:|:||.||||...|.||:||||||:|..:.||.::..|
Zfish   282 ACCCANILCHLFTKYR---RNEAKRREVLSAAAAVGVSVAFGAPIGGVLFSLEEVSYYFPLKTLW 343

  Fly   358 RGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLVCGLGGASY--- 419
            |.||||:..|...|.:.. |.|:..|  ||...|.:  |:...||..|.|:|:..|:.||.:
Zfish   344 RSFFAALVAAFTLRSINP-FGNSRLV--LFYVEFHS--PWHLLELIPFILLGIFGGIWGAFFIRA 403

  Fly   420 -VWVHRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSSI----SFPLGTGQFLAGELSTHEQVT 479
             :|..||     |...|:..        ||....|:|:::    :||....:     :||.|.::
Zfish   404 NIWWCRR-----RKTTRLGH--------YPVLEVLVVTAVTAVLAFPNSYTR-----MSTSELIS 450

  Fly   480 QLFS----------------NFTWSRDDLTVEQAAVVTHWMTSYTSVFGNLVIYTLFTFVVSIIA 528
            :||:                :.|.|..|...::.|    ....||::: .|.:..:|..:::::.
Zfish   451 ELFNDCGLLDSSQLCNYSNVSVTKSSSDALPDRPA----GPDVYTAMW-QLSLALIFKMLITVVT 510

  Fly   529 STIPVPSGMFIPVFKIGAGFGRLVG---EFMAVTFPHGVRYGGRLSP----IMPGGYAVVGAAAF 586
            ..:.:|||:|||...:||..|||:|   |.:|......|.:.|..||    |.||.||:|||.|.
Zfish   511 FGMKLPSGLFIPSMAVGAIAGRLLGVGMEQLAYYHHDWVIFRGWCSPGADCITPGLYAMVGATAC 575

  Fly   587 SGSVTH-TVSVAVIIFEMTGQITHVVPVMIAVLVANAVA-ALLQPSIYDSIILIKKLPYLP---- 645
            .|.||. |||:.||:||:||.:.::||:|.|.:.:..|| ||.:..||::.|.:...|:|.
Zfish   576 LGGVTRMTVSLVVIMFELTGGLEYIVPLMAATMTSKWVADALGREGIYEAHIRLNGYPFLESKEE 640

  Fly   646 --------DLL--PSSSGMYSIFVEDFM-VRDVKYIWHGISYQKLKEVLKLNKTLRSLPLVDSPD 699
                    |::  ..|....|:..:|.| |.:|:.:....||.             ..|:|.|.:
Zfish   641 FSHKTLAMDVMRPRRSDPPLSVITQDGMNVEEVESLIAETSYS-------------GFPVVVSHE 692

  Fly   700 NMILLGSVQRYELIKMIEKHIGREKRMEVAQK 731
            :..|:|.|||.:|:..|:....|::.:..|.:
Zfish   693 SQRLVGFVQRRDLVISIDNARQRQEGVVSASR 724

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	172/558 (31%)
		CBS_pair_SF	659..>718	CDD:449531	16/59 (27%)
		CBS repeat	664..715	CDD:341358	13/50 (26%)
		CBS_pair_SF	<1032..1096	CDD:449531
		CBS repeat	1053..1095	CDD:341358
clcn5a	XP_001920783.2	ClC_3_like	129..635	CDD:239656	169/536 (32%)
		CBS_pair_voltage-gated_CLC_euk_bac	646..796	CDD:341367	21/92 (23%)
		CBS repeat	652..747	CDD:341367	20/86 (23%)
		CBS repeat	753..795	CDD:341367