Protein Alignment ClC-a and clcn7

DIOPT Version :10

• Sequence 1: NP_788639.1
• Gene: ClC-a / 41428
• FlyBaseID: FBgn0051116
• Length: 1193
• Species: Drosophila melanogaster
• Sequence 2: NP_001071005.1
• Gene: clcn7 / 553351
• ZFINID: ZDB-GENE-061103-196
• Length: 795
• Species: Danio rerio
• Alignment Length: 743
• Identity: 187/743 - (25%)
• Similarity: 313/743 - (42%)
• Gaps: 174/743 - (23%)

  Fly   172 WVFLALLGIIMALLSFIMDKGISICTNARIWLYRDLTSQPFVQ-------YIAWVSLPVCLILFS 229
            ||...|:|::..|::.::|..:......:.:..:. ..:.|.:       .|.|..|....::..
Zfish   114 WVICGLIGLLTGLIACLIDIAVENLAGLKYFAVKQ-NIEKFTELGGLSLSLILWAVLNSAFVMVG 177

  Fly   230 AGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLGKEGPFVHIAS 294
            |..|....|.:.|||||::|..|.||::...:..||||.||.|:..::..|:.:|||||.:|..:
Zfish   178 AIIVAFFEPIAAGSGIPQIKCYLNGVKVPRVVRLKTLVVKVFGVICSVAGGLAVGKEGPMIHSGA 242

  Fly   295 IVAQLLSK-----LVTSFQGIYENESRNSE---MLAAACAVGVGACFAAPVGGVLFSIEVTTTYF 351
            :||..:|:     |...|: ::|...|::|   .::|..|.||.|.|.|||||||||:|...:::
Zfish   243 VVAAGVSQGRSTSLKKDFK-MFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFW 306

  Fly   352 AVRNYWRGFFAA-VCGATVFRLLAVWFQNADTVRALFLTNF----TTEFPFDPQELFVFALIGLV 411
            .....||.|||: |...|:...|:::.|....:.:..|.||    :....::..|:.:|.::|.:
Zfish   307 NQLLTWRIFFASMVSSFTLNFFLSIYHQKPGELSSPGLINFGRFDSDSVQYNLYEIPLFIIMGAL 371

  Fly   412 CGLGGASY----VW--------VHRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSSISF---- 460
            .|:.||.:    .|        :||..:..|.:.                .:|.:.:::||
Zfish   372 GGMLGALFNLLNYWLTIFRIRYIHRPCLQVMEAM----------------LVAAVTATVSFAMIY 420

  Fly   461 ------PLGTGQFLAGELSTHEQVTQLFSNFTWSRDDLTVEQAAVVTHWMT----SYTSVFGN-- 513
                  |||...       |.|...|||.        ...|..|:.|.:..    |..|:|.|
Zfish   421 FSTECQPLGPDH-------TEEYPLQLFC--------ADGEYNAMATAFFNTPERSVRSLFHNPP 470

  Fly   514 -------LVIYTLFTFVVSIIASTIPVPSGMFIPVFKIGAGFGRLVGEFMA-VTFPHGVRYGGRL 570
                   |.::||..|::::....:.|.:|:|||...|||.:|||.|..:: :|....:...
Zfish   471 GTYNPMTLGVFTLAYFLLAVWTYGLTVSAGVFIPSLLIGAAWGRLFGILLSFITTSKSIWAD--- 532

  Fly   571 SPIMPGGYAVVGAAA-FSGSVTHTVSVAVIIFEMTGQITHVVPVMIAVLVANAVAALLQPSIYDS 634
                ||.||::|||| ..|.|..|:|:.||:.|.||.:|:..|:|:.::.|..|.......:||.
Zfish   533 ----PGKYALIGAAAQLGGIVRMTLSLTVILVEATGNVTYGFPIMLVLMTAKIVGDYFVEGLYDI 593

  Fly   635 IILIKKLPYLPDLLPSSSGMYSIFVEDFMVRDVKYIWHGISYQKLKEVLKLNKTL-------RSL 692
            .|.::.:|:|....|.:|  :.:...:.|...|      ..:.::::|..:...|       ...
Zfish   594 HIKLQSVPFLHWEAPPTS--HWLTAREVMSSQV------TCFNRIEKVGTIVDVLSNTSTNHNGF 650

  Fly   693 PLV------DSPDNMILLGSVQRYELIKMIEKHIGREKRMEVAQKWQKEAQERALE--EEKKKQE 749
            |:|      |.|..  |.|.|.|.:||.:: ||              |...|||..  .::|.|.
Zfish   651 PVVTHVTEIDEPSK--LCGLVLRSQLIVLL-KH--------------KVFVERAFSRFSQRKLQL 698

  Fly   750 VELKMRRPSRFEVLPAPDILSLRQIANDEMLPPKKRAETMHGSLAPRKSILKKTNSFNLKTYAQP 814
            .:.:...| ||                    ||   .:::|.|...|:.::..|...|
Zfish   699 KDFRDAYP-RF--------------------PP---IQSIHVSQDERECMMDLTEFMN------- 732

  Fly   815 MGHSPSITPYTTITGNSEFRIRSAFEAI 842
                |  ||||.....|..|:...|.|:
Zfish   733 ----P--TPYTVPQETSLPRVFKLFRAL 754

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	144/530 (27%)
		CBS_pair_SF	659..>718	CDD:449531	14/71 (20%)
		CBS repeat	664..715	CDD:341358	13/63 (21%)
		CBS_pair_SF	<1032..1096	CDD:449531
		CBS repeat	1053..1095	CDD:341358
clcn7	NP_001071005.1	ClC_6_like	82..604	CDD:239657	143/529 (27%)
		CBS_pair_voltage-gated_CLC_euk_bac	615..780	CDD:341367	41/200 (21%)
		CBS repeat	621..730	CDD:341367	30/155 (19%)
		CBS repeat	736..779	CDD:341367	6/19 (32%)