Protein Alignment ClC-a and ClC-c

DIOPT Version :10

• Sequence 1: NP_788639.1
• Gene: ClC-a / 41428
• FlyBaseID: FBgn0051116
• Length: 1193
• Species: Drosophila melanogaster
• Sequence 2: NP_730105.3
• Gene: ClC-c / 39759
• FlyBaseID: FBgn0036566
• Length: 893
• Species: Drosophila melanogaster
• Alignment Length: 757
• Identity: 218/757 - (28%)
• Similarity: 331/757 - (43%)
• Gaps: 178/757 - (23%)

  Fly    67 HVQR--HPKIKSHAFYPCPPPAENA----RDSDSSDDDDPIGYIDTLMYGRYTKDLGEFAKDEAR 125
            |.||  |..:.:|:.:  ..|.:.|    ..||..||...||..:......:.:|:   |:|..|
  Fly   123 HNQRTMHQHVPTHSAF--GDPMDGALSFYGSSDVQDDIPGIGQYEDFHTIDWQRDI---ARDRMR 182

  Fly   126 KLKILEKRRKQEDKQRNKELLGKHSTRAKRVSSWIWRHTVARLGEDWVFLALLGIIMALLSFIMD 190
            ...|::||:.                     |.|.........|..|:.:.|:||....::.::|
  Fly   183 HRYIVKKRQD---------------------SLWDLIKGSIDAGSGWLCVLLVGIAAGCVAGMVD 226

  Fly   191 KGIS--------ICTNARIWLYRDLTSQP----------------------------------FV 213
            .|.|        ||..| .|..|:....|                                  ::
  Fly   227 IGASWMSDLKHGICPPA-FWFNREQCCYPAKQSVFEEGNCSTWKTWPEIFGLDRNGTGPYIVAYI 290

  Fly   214 QYIAWVSLPVCLILFSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLG 278
            .|:.|..|...|   ||..|.:.||.:.||||||:||||.|..::.||...||:.|.:||..::.
  Fly   291 WYVLWALLFASL---SASLVRMFAPYACGSGIPEIKTILSGFIIRGYLGKWTLLIKSVGLMLSVS 352

  Fly   279 SGMPLGKEGPFVHIASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFS 343
            :|:.||||||.|||||.:..:.|.:   |.....||::..|:|:||.|.||...|.||:||||||
  Fly   353 AGLTLGKEGPMVHIASCIGNIFSHV---FPKYGRNEAKKREILSAAAAAGVSVAFGAPIGGVLFS 414

  Fly   344 IEVTTTYFAVRNYWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALI 408
            :|..:.||.::..||.||.|:..|.|.|.|.. |.|..:|  ||...:...:.|  .||..|..:
  Fly   415 LEEVSYYFPLKTLWRSFFCALIAAFVLRSLTP-FGNEHSV--LFFVEYNKPWIF--FELIPFVFL 474

  Fly   409 GLVCGLGGASYVWVHRRYVLFMRSNK---RMNKFLQKNRFLYPG----FLALLVSSISFPLGTGQ 466
            |::.|:.|          ..|:::|.   |..||.:..:  ||.    |:.|:.:.|.:|   ..
  Fly   475 GIMGGVIG----------TFFIKANLWWCRYRKFSKLGQ--YPVMEVLFVTLVTAIICYP---NP 524

  Fly   467 FLAGELSTHEQVTQLFSNFT----------WSRDDLTVEQAAV-VTH---------WMTSYTSVF 511
            |.  .::.:|.:..|.|..:          :.|.::|...:.: ||.         |:...|.:.
  Fly   525 FT--RMNMNELIFLLVSKCSPGDVTNPLCDYKRMNITSGNSFIEVTEPGPGVYSSIWLLMLTFIL 587

  Fly   512 GNLVIYTLFTFVVSIIASTIPVPSGMFIPVFKIGAGFGRLVG---EFMAVTFPHGVRYGGRLSP- 572
              .:..|:|||       .:.||:|:|||...:||..||:||   |..|.::|:...:.|..:.
  Fly   588 --KLALTIFTF-------GMKVPAGLFIPSLLLGAIMGRIVGIGVEQFAYSYPNIWFFTGECADS 643

  Fly   573 --IMPGGYAVVGAAAFSGSVTH-TVSVAVIIFEMTGQITHVVPVMIAVLVANAVA-ALLQPSIYD 633
              |.||.||||||||..|.||. |||:.||:||:||.:.::||:|.|.:.:..|. ||.:..|||
  Fly   644 NLITPGLYAVVGAAAVLGGVTRMTVSLVVIMFELTGGVRYIVPLMAAAMASKWVGDALGRQGIYD 708

  Fly   634 SIILIKKLPYLPD-------------LLPSSSGMYSIFVEDFM-VRDVKYIWHGISYQKLKEVLK 684
            :.|.:...|:|..             :.|..:...::..:|.| |.||:.:        |||.
  Fly   709 AHIALNGYPFLDSKEEFAHTTLAADVMQPKRNETLNVITQDSMTVDDVENL--------LKET-- 763

  Fly   685 LNKTLRSLPLVDSPDNMILLGSVQRYELIKMIEKHIGREKRM 726
               .....|:|.|.:|..|:|.|.|.:|    ...||..||:
  Fly   764 ---EHNGYPVVVSRENQYLVGFVLRRDL----NLAIGNAKRL 798

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	173/551 (31%)
		CBS_pair_SF	659..>718	CDD:449531	17/59 (29%)
		CBS repeat	664..715	CDD:341358	15/50 (30%)
		CBS_pair_SF	<1032..1096	CDD:449531
		CBS repeat	1053..1095	CDD:341358
ClC-c	NP_730105.3	ClC_3_like	215..719	CDD:239656	170/541 (31%)
		CBS_pair_voltage-gated_CLC_euk_bac	730..878	CDD:341367	22/86 (26%)
		CBS repeat	736..829	CDD:341367	22/80 (28%)
		CBS repeat	835..877	CDD:341367