DRSC/TRiP Functional Genomics Resources

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Protein Alignment ClC-a and Clcn7

DIOPT Version :10

Sequence 1:NP_788639.1 Gene:ClC-a / 41428 FlyBaseID:FBgn0051116 Length:1193 Species:Drosophila melanogaster
Sequence 2:NP_113756.1 Gene:Clcn7 / 29233 RGDID:61836 Length:803 Species:Rattus norvegicus


Alignment Length:786 Identity:197/786 - (25%)
Similarity:334/786 - (42%) Gaps:162/786 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   119 FAKDEARKLKILEKRRKQEDKQRNKELLGKHSTRAKRVSSWIWRHTVARLGE--DWVFLALLGII 181
            |.|:.....|:|..:.:..|...::..|.....|  |::     ||..|..|  .||..||:||:
  Rat    77 FPKEIPHNEKLLSLKYESLDYDNSENQLFLEEER--RIN-----HTAFRTVEIKRWVICALIGIL 134

  Fly   182 MALLSFIMDKGISICTNARIWLYRD----LTSQPFVQY--IAWVSLPVCLILFSAGFVHLIAPQS 240
            ..|::..:|..:......:..:.:|    .|.:..:.:  :.|.:|....:|..:..|..|.|.:
  Rat   135 TGLVACFIDIVVENLAGLKYRVIKDNIDKFTEKGGLSFSLLLWATLNSAFVLVGSVIVAFIEPVA 199

  Fly   241 IGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLGKEGPFVHIASIVAQLLSK--- 302
            .|||||::|..|.||::...:..||||.||.|:..::..|:.:|||||.:|..|::|..:|:   
  Rat   200 AGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRS 264

  Fly   303 --LVTSFQGIYENESRNSE---MLAAACAVGVGACFAAPVGGVLFSIEVTTTYFAVRNYWRGFFA 362
              |...|: |:|...|::|   .::|..|.||.|.|.|||||||||:|...:::.....||.|||
  Rat   265 TSLKRDFK-IFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFA 328

  Fly   363 AVCGA-TVFRLLAVWFQNADTVRALFLTNF----TTEFPFDPQELFVFALIGLVCGLGGASYVWV 422
            ::... |:..:|:::..|...:.:..|.||    :.:..:...|:.||..:|:|.|:.||     
  Rat   329 SMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGILGA----- 388

  Fly   423 HRRYVLFMRSNKRMNKFLQKNRFLYPGFL----ALLV-----------------------SSISF 460
                 :|...|..:..|  :.|:::...|    |:||                       ||:|:
  Rat   389 -----VFNALNYWLTMF--RIRYIHRPCLQVIEAMLVAAVTATVAFVLIYSSRDCQPLQGSSMSY 446

  Fly   461 PL----GTGQF---LAGELSTHEQ-VTQLFSNFTWSRDDLTVEQAAVVTHWMTSYTSVFGNLVIY 517
            ||    ..|::   .|...:|.|: |..||.:...|.:.:|                    |.::
  Rat   447 PLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPMT--------------------LGLF 491

  Fly   518 TLFTFVVSIIASTIPVPSGMFIPVFKIGAGFGRLVGEFMAVTFPHGVRYGGRLSPIMPGGYAVVG 582
            ||..|.::.....:.|.:|:|||...|||.:|||.|  :::::..|......     ||.||::|
  Rat   492 TLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFG--ISMSYLTGAAIWAD-----PGKYALMG 549

  Fly   583 AAA-FSGSVTHTVSVAVIIFEMTGQITHVVPVMIAVLVANAVAALLQPSIYDSIILIKKLPYLPD 646
            ||| ..|.|..|:|:.||:.|.|..:|:..|:|:.::.|..|..:....:||..|.::.:|:|..
  Rat   550 AAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHW 614

  Fly   647 LLPSSSGMYSIFVEDFMVRDVKYIWH----GISYQKLKEVLKLNKTLRSLPLVDSPDNMILLGSV 707
            ..|.:|  :|:...:.|...|..:..    ||....|.:....:.....:..|.......|.|.:
  Rat   615 EAPVTS--HSLTAREVMSTPVTCLRRREKVGIIVDVLSDTASNHNGFPVVEDVGDTQPARLQGLI 677

  Fly   708 QRYELIKMIEKHIGREKRMEVAQKWQKEAQERALEEEKKKQEVELKMRRPSRFEVLPA-PDILSL 771
            .|.:||.:: ||                   :...|......|:.::|.....:..|. |.|.|:
  Rat   678 LRSQLIVLL-KH-------------------KVFVERSNMGLVQRRLRLKDFRDAYPRFPPIQSI 722

  Fly   772 RQIANDEMLPPKKRAETMHGSLAPRKSILKKTNSFNLKTYAQPMGHSPSITPYTTITGNSEFRIR 836
             .::.||      |..||                 :|..:..|       :|||.....|..|:.
  Rat   723 -HVSQDE------RECTM-----------------DLSEFMNP-------SPYTVPQEASLPRVF 756

  Fly   837 SAFEAI 842
            ..|.|:
  Rat   757 KLFRAL 762

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ClC-aNP_788639.1 ClC_1_like 171..646 CDD:239655 148/529 (28%)
CBS_pair_SF 659..>718 CDD:449531 11/62 (18%)
CBS repeat 664..715 CDD:341358 10/54 (19%)
CBS_pair_SF <1032..1096 CDD:449531
CBS repeat 1053..1095 CDD:341358
Clcn7NP_113756.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..46
ClC_6_like 93..618 CDD:239657 156/571 (27%)
Selectivity filter part_1. /evidence=ECO:0000250 201..205 3/3 (100%)
Selectivity filter part_2. /evidence=ECO:0000250 243..247 3/3 (100%)
Selectivity filter part_3. /evidence=ECO:0000250 510..514 2/3 (67%)
CBS_pair_voltage-gated_CLC_euk_bac 624..788 CDD:341367 34/190 (18%)
CBS repeat 630..738 CDD:341367 25/151 (17%)
CBS repeat 744..787 CDD:341367 6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

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