DRSC/TRiP Functional Genomics Resources

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Protein Alignment ClC-a and Clcn2

DIOPT Version :10

Sequence 1:NP_788639.1 Gene:ClC-a / 41428 FlyBaseID:FBgn0051116 Length:1193 Species:Drosophila melanogaster
Sequence 2:NP_058833.1 Gene:Clcn2 / 29232 RGDID:2361 Length:907 Species:Rattus norvegicus


Alignment Length:1104 Identity:454/1104 - (41%)
Similarity:594/1104 - (53%) Gaps:243/1104 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   103 YIDTLMYGRYTKDLGEFAKDEARKLKI--LEKRRKQEDKQRNKELLGKHSTRAKR---VSSWIWR 162
            |..||||||||::||.|||:||.::::  .|..:.....:...|||....:|..|   .|....:
  Rat    23 YEQTLMYGRYTQELGAFAKEEAARIRLGGPEPWKGSPSARATPELLEYGQSRCARCRICSVRCHK 87

  Fly   163 HTVARLGEDWVFLALLGIIMALLSFIMDKGISICTNARIWLYRDLTSQPFVQYIAWVSLPVCLIL 227
            ..|:|:||||:||.|||::|||:|:.||..|::|..|:.|:.|.|.:...:||:|||:.||.||.
  Rat    88 FLVSRVGEDWIFLVLLGLLMALVSWAMDYAIAVCLQAQQWMSRGLNTNILLQYLAWVTYPVVLIT 152

  Fly   228 FSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLGKEGPFVHI 292
            |||||..::|||::||||||||||||||.||||||.||.||||||||..||||||||||||||||
  Rat   153 FSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFVAKVIGLTCALGSGMPLGKEGPFVHI 217

  Fly   293 ASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTTTYFAVRNYW 357
            ||:.|.||||.::.|.|||||||||:||||||||||||.|||||:||||||||||:|:|||||||
  Rat   218 ASMCAALLSKFLSLFGGIYENESRNTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYW 282

  Fly   358 RGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLVCGLGGASYVWV 422
            ||||||...|.:||:||||.::.:|:.|||.|.|..:||||.|||..||:||:..|.|||.:|::
  Rat   283 RGFFAATFSAFIFRVLAVWNRDEETITALFKTRFRLDFPFDLQELPAFAVIGIASGFGGALFVYL 347

  Fly   423 HRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSSISFPLGTGQFLAGELSTHEQVTQLFSNFTW 487
            :|:.|..||..|.:|:||.|.|.|:|..:.||:|:::||.|.|||:||:||..|.:..||.|.||
  Rat   348 NRKIVQVMRKQKTINRFLMKKRLLFPALVTLLISTLTFPPGFGQFMAGQLSQKETLVTLFDNRTW 412

  Fly   488 SRDDLTVEQAAVVTH--WMTSYTSVFGNLVIYTLFTFVVSIIASTIPVPSGMFIPVFKIGAGFGR 550
            .|..|..:..|..|.  |.....:||..|||:.|..|.:|.:|:|||||.|.|:|||.|||.|||
  Rat   413 VRQGLVEDLGAPSTSQAWSPPRANVFLTLVIFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGR 477

  Fly   551 LVGEFMAVTFPHGVRYGGRLSPIMPGGYAVVGAAAFSGSVTHTVSVAVIIFEMTGQITHVVPVMI 615
            ||||.||..||.|:........|:|||||||||||.:|:||||||.|||:||:||||.|::||||
  Rat   478 LVGESMAAWFPDGIHTDSSTYRIVPGGYAVVGAAALAGAVTHTVSTAVIVFELTGQIAHILPVMI 542

  Fly   616 AVLVANAVAALLQPSIYDSIILIKKLPYLPDLLPSSSGMYSIFVEDFMVRDVKYIWHGISYQKLK 680
            ||::|||||..||||:|||||.||||||||:|.......|.:.|||.|||||.::....:::.|:
  Rat   543 AVILANAVAQSLQPSLYDSIIRIKKLPYLPELGWGRHQQYRVRVEDIMVRDVPHVALSCTFRDLR 607

  Fly   681 EVLKLNKTL-RSLPLVDSPDNMILLGSVQRYELIKMIEKHIGREKRMEVAQKWQKEAQERALEEE 744
              |.|::|. |.|.||:||::||||||::|.:::.::...:...:|.:..||.:|.         
  Rat   608 --LALHRTKGRMLALVESPESMILLGSIERSQVVALLGAQLSPARRRQHMQKLRKA--------- 661

  Fly   745 KKKQEVELKMRRPSRFEVLPAPDILSLRQIANDEMLPPKKRAETMHGSLAPRKSILKKTNSFNLK 809
                                             :|.||..                         
  Rat   662 ---------------------------------QMSPPSD------------------------- 668

  Fly   810 TYAQPMGHSPSITPYTTITGNSEFRIRSAFEAIFKKSTTLQDVQPDPETGSLSPAASNHEVEVPR 874
                                                    |:..|..||                
  Rat   669 ----------------------------------------QESPPSSET---------------- 677

  Fly   875 TPSTPGVSKKVQLPAQSNWDFVTDQIMLQVNPISTESNKMPAEKDFTDKALSNNGDSSKQSPSIK 939
                                    .|..|||   ||.:..|.....|.|.|         .|::|
  Rat   678 ------------------------SIRFQVN---TEDSGFPGAHGQTHKPL---------KPALK 706

  Fly   940 FKANKVADVNRSPQTAKRCSKIRFAN--EVGVN------GSPTRTKCKIKPENVLGYSIEDVDET 996
                      |.|..|....:....|  ..|:.      |||                  .::.|
  Rat   707 ----------RGPSNATSLQEGTTGNMESAGIALRSLFCGSP------------------PLEST 743

  Fly   997 TNPESLAESIQKPKSVRLPRERVID------MSPEDQKQWELEEMLKPIDLQKANVHIDPSPFQL 1055
            |:....:||..|.|..|:......|      ||||:..:||.:::.:|::.  ::..|||:||||
  Rat   744 TSELEKSESCDKRKLKRVRISLASDSDLEGKMSPEEILEWEEQQLDEPVNF--SDCKIDPAPFQL 806

  Fly  1056 VERTSILKVHSLFSMVGINHAYVTKIGRLVGVVGLKELRKAIEDINSNSFVPPTRDEDADEKPAV 1120
            |||||:.|.|::||::|::|||||.||||:|:|.|||||||||...:...|            .|
  Rat   807 VERTSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKELRKAIEGSVTAQGV------------KV 859

  Fly  1121 EKPLLSTNSSDKAVDMTVTSMDSALSNSENCSDIEMEHIKHTDKGTVSLTMPPQESKQSPSADK 1184
            ..||.|..             |||.|:    ||.|...: |...|..|....|:|...|.|.||
  Rat   860 RPPLASFR-------------DSATSS----SDTETTEV-HALWGPRSRHGLPREGTPSDSDDK 905

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
ClC-aNP_788639.1 ClC_1_like 171..646 CDD:239655 295/476 (62%)
CBS_pair_SF 659..>718 CDD:449531 25/59 (42%)
CBS repeat 664..715 CDD:341358 21/51 (41%)
CBS_pair_SF <1032..1096 CDD:449531 34/63 (54%)
CBS repeat 1053..1095 CDD:341358 28/41 (68%)
Clcn2NP_058833.1 Essential for channel gating by both voltage and cell volume. /evidence=ECO:0000269|PubMed:1334533 22..40 11/16 (69%)
Modulates channel gating by both voltage and cell volume. /evidence=ECO:0000269|PubMed:1334533 42..55 3/12 (25%)
ClC_1_like 96..573 CDD:239655 295/476 (62%)
Selectivity filter part_1. /evidence=ECO:0000250 167..171 3/3 (100%)
Selectivity filter part_2. /evidence=ECO:0000250 209..213 3/3 (100%)
Selectivity filter part_3. /evidence=ECO:0000250 463..467 2/3 (67%)
CBS_pair_voltage-gated_CLC_euk_bac 585..847 CDD:341367 104/452 (23%)
CBS repeat 591..798 CDD:341367 67/397 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 650..720 26/238 (11%)
CBS repeat 804..846 CDD:341367 28/41 (68%)