Protein Alignment ClC-a and Clcn5

DIOPT Version :10

• Sequence 1: NP_788639.1
• Gene: ClC-a / 41428
• FlyBaseID: FBgn0051116
• Length: 1193
• Species: Drosophila melanogaster
• Sequence 2: NP_001401322.1
• Gene: Clcn5 / 25749
• RGDID: 2362
• Length: 816
• Species: Rattus norvegicus
• Alignment Length: 760
• Identity: 220/760 - (28%)
• Similarity: 336/760 - (44%)
• Gaps: 187/760 - (24%)

  Fly    92 SDSSDDD--------------DPIGYIDTLMYGRYTKDLGEFAKDEARKLKILEK---------- 132
            |.|||:|              |.:..:|..:.|..:.:.|...... |.:..||:
  Rat    23 SSSSDEDLMDIPGTAMDFSMRDDVPPLDREIEGNKSYNGGGIGSSN-RIMDFLEEPIPGVGTYDD 86

  Fly   133 -------RRKQEDKQRNKELLGKHSTRAKRVSSWIWRHTVARLGEDWVFLALLGIIMALLSFIMD 190
                   |.|..|:.|::|:     |...:.|:|...|:|:.....|:.:.|:|::...|:.::|
  Rat    87 FNTIDWVREKSRDRDRHREI-----TNKSKESTWALIHSVSDAFSGWLLMLLIGLLSGSLAGLID 146

  Fly   191 ----------KGI----------SICTNARIWLYRDLTSQP----------------------FV 213
                      :||          ..|.|:....:.|....|                      :.
  Rat   147 ISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEDRDKCPEWNSWSQLIISTDQGAFAYIVNYF 211

  Fly   214 QYIAWVSLPVCLILFSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLG 278
            .|:.|..|   ....:...|...||.:.||||||:||||.|..::.||...|||.|.|.|...:.
  Rat   212 MYVLWALL---FAFLAVSLVKAFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVS 273

  Fly   279 SGMPLGKEGPFVHIASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFS 343
            ||:.||||||.||:|.....:|......::   :||::..|:|:||.|.||...|.||:||||||
  Rat   274 SGLSLGKEGPLVHVACCCGNILCHCFNKYR---KNEAKRREVLSAAAAAGVSVAFGAPIGGVLFS 335

  Fly   344 IEVTTTYFAVRNYWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALI 408
            :|..:.||.::..||.||||:..|...|.:.. |.|:..|  ||...|.|  |:...||..|.::
  Rat   336 LEEVSYYFPLKTLWRSFFAALVAAFTLRSINP-FGNSRLV--LFYVEFHT--PWHLFELVPFIVL 395

  Fly   409 GLVCGLGGASYVWVHRRYVLFMRSN-----KRMNKFLQKNRFLYPGFLALLVSSI----SFPLGT 464
            |:..||.||          ||:|:|     ||....|.|    ||....|:|::|    :||
  Rat   396 GIFGGLWGA----------LFIRTNIAWCRKRKTTQLGK----YPVVEVLIVTAITAILAFP--- 443

  Fly   465 GQFLAGELSTHEQVTQLF---------------SNFTWSR-DDLTVEQAAVVTH---WMTSYTSV 510
            .::.  .:||.|.:::||               ::|..|: .:|....|.|..:   |..:.|.:
  Rat   444 NEYT--RMSTSELISELFNDCGLLDSSKLCDYENHFNTSKGGELPDRPAGVGVYSAMWQLALTLI 506

  Fly   511 FGNLVIYTLFTFVVSIIASTIPVPSGMFIPVFKIGAGFGRLVGEFM-AVTFPH---GVRYGGRLS 571
            .  .::.|:|||.:.|       |||:|||...:||..|||:|..| .:.:.|   |: :....|
  Rat   507 L--KIVITIFTFGMKI-------PSGLFIPSMAVGAIAGRLLGVGMEQLAYYHHDWGI-FNSWCS 561

  Fly   572 P----IMPGGYAVVGAAAFSGSVTH-TVSVAVIIFEMTGQITHVVPVMIAVLVANAVA-ALLQPS 630
            .    |.||.||:|||||..|.||. |||:.||:||:||.:.::||:|.|.:.:..|| ||.:..
  Rat   562 QGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREG 626

  Fly   631 IYDSIILIKKLPYLP------------DLLP--SSSGMYSIFVEDFM-VRDVKYIWHGISYQKLK 680
            |||:.|.:...|:|.            |::.  .:..:.::..:|.| |.||
  Rat   627 IYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDV------------- 678

  Fly   681 EVLKLNKTLRSLPLVDSPDNMILLGSVQRYELIKMIEKHIGREKR 725
            |.:....|....|:|.|.::..|:|.|.|.:||..||.  .|:|:
  Rat   679 ETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIEN--ARKKQ 721

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	177/566 (31%)
		CBS_pair_SF	659..>718	CDD:449531	17/59 (29%)
		CBS repeat	664..715	CDD:341358	14/50 (28%)
		CBS_pair_SF	<1032..1096	CDD:449531
		CBS repeat	1053..1095	CDD:341358
Clcn5	NP_001401322.1	ClC_3_like	142..640	CDD:239656	172/537 (32%)
		Selectivity filter part_1. /evidence=ECO:0000250	237..241		3/3 (100%)
		Selectivity filter part_2. /evidence=ECO:0000250	279..283		3/3 (100%)
		Selectivity filter part_3. /evidence=ECO:0000250	523..527		2/3 (67%)
		CBS_pair_voltage-gated_CLC_euk_bac	651..801	CDD:341367	21/86 (24%)
		CBS repeat	657..752	CDD:341367	20/80 (25%)
		CBS repeat	758..800	CDD:341367