DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ClC-a and Clcn1

DIOPT Version :10

Sequence 1:NP_788639.1 Gene:ClC-a / 41428 FlyBaseID:FBgn0051116 Length:1193 Species:Drosophila melanogaster
Sequence 2:NP_037279.1 Gene:Clcn1 / 25688 RGDID:2360 Length:994 Species:Rattus norvegicus


Alignment Length:1044 Identity:404/1044 - (38%)
Similarity:574/1044 - (54%) Gaps:203/1044 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    72 PKIKSHAFYPCPP---PAENA-------RDSDSSDDDDPIGYIDTLMYGRYTKDLGEFAKDEARK 126
            |:.:...|..|..   |:||.       :|.....:..|     |.:||.:.:.....|:|....
  Rat    20 PQYQYMPFEHCTSYGLPSENGGLQHRPRKDLGPRHNAHP-----TQIYGHHKEQYSYQAQDRGIP 79

  Fly   127 LKILEKRRKQEDKQRNKELLGK-HSTRAKRVSSWIWRHTVARLGEDWVFLALLGIIMALLSFIMD 190
                    |:.|.....:.|.: |.::.:.....:.|....:|||||:||.|||::|||:|:.||
  Rat    80 --------KKTDSSSTVDSLDEDHYSKCQDCVHRLGRVLRRKLGEDWIFLVLLGLLMALVSWCMD 136

  Fly   191 KGISICTNARIWLYRDLTSQPFVQYIAWVSLPVCLILFSAGFVHLIAPQSIGSGIPEMKTILRGV 255
            ...:....|..|.|..:.....:||:|||:.|:.||||||.|..||:||::||||||||||||||
  Rat   137 YVSAKSLQAYKWTYAQMQPSLPLQYLAWVTFPLILILFSALFCQLISPQAVGSGIPEMKTILRGV 201

  Fly   256 QLKEYLTFKTLVAKVIGLTATLGSGMPLGKEGPFVHIASIVAQLLSKLVTSFQGIYENESRNSEM 320
            .||||||.|..||||:.|||.||||:|:||||||||||||.|.:|||.::.|.|:||.....:::
  Rat   202 VLKEYLTLKAFVAKVVALTAGLGSGIPVGKEGPFVHIASICAAVLSKFMSMFSGVYEQPYYYTDI 266

  Fly   321 LAAACAVGVGACFAAPVGGVLFSIEVTTTYFAVRNYWRGFFAAVCGATVFRLLAVWFQNADTVRA 385
            |...||||||.||..|:||||||||||:|||||||||||||||...|.|||:||||.::|.|:.|
  Rat   267 LTVGCAVGVGCCFGTPLGGVLFSIEVTSTYFAVRNYWRGFFAATFSAFVFRVLAVWNKDAVTITA 331

  Fly   386 LFLTNFTTEFPFDPQELFVFALIGLVCGLGGASYVWVHRRYVLFMRSNKRMNKFLQKNRFLYPGF 450
            ||.|||..:||||.:||..||:||:.||..||.:|::||:.:|.:|.:|.:::||.|:|.||||.
  Rat   332 LFRTNFRMDFPFDLKELPAFAVIGICCGFLGAVFVYLHRQVMLGVRKHKALSQFLAKHRLLYPGI 396

  Fly   451 LALLVSSISFPLGTGQFLAGELSTHEQVTQLFSNFTWSR---DDLTVEQAAVVTHWMTSYTSVFG 512
            :..:::|::||.|.|||:||||...|.::.||.|.||.:   |..::.|:||   |:....:|..
  Rat   397 VTFVIASLTFPPGMGQFMAGELMPREAISTLFDNNTWVKHIGDPKSLGQSAV---WIHPQVNVVI 458

  Fly   513 NLVIYTLFTFVVSIIASTIPVPSGMFIPVFKIGAGFGRLVGEFMAVTFPHGVRYGGRLSPIMPGG 577
            .::::.:..|.:||:|:|:|:|.|.|:|||.:||.|||||||.||:.||.|:.:...:..|:|||
  Rat   459 IILLFFVMKFWMSIVATTMPIPCGGFMPVFVLGAAFGRLVGEIMAMLFPEGILFDDIIYKILPGG 523

  Fly   578 YAVVGAAAFSGSVTHTVSVAVIIFEMTGQITHVVPVMIAVLVANAVAALLQPSIYDSIILIKKLP 642
            |||:||||.:|:|:||||.|||.||:||||.|::|:|:||::||.||..||||:|||||.:||||
  Rat   524 YAVIGAAALTGAVSHTVSTAVICFELTGQIAHILPMMVAVILANMVAQSLQPSLYDSIIQVKKLP 588

  Fly   643 YLPDLLPSSSGMYSIFVEDFMVRDVKYIWHGISYQKLKEVLKLNKTLRSLPLVDSPDNMILLGSV 707
            |||||..:....::|||||.||||||::....:|.:|:.:|: ..|:::||||||.|:|||||||
  Rat   589 YLPDLGWNQLSKFTIFVEDIMVRDVKFVSASCTYGELRNLLQ-TTTVKTLPLVDSKDSMILLGSV 652

  Fly   708 QRYELIKMIEKHIGREKRMEVAQKWQKEAQERALEEEKKKQEVELKMRRPSRFEVLPAPDILSLR 772
            :|.||..::::|:..|:|::.||...::..|                                  
  Rat   653 ERSELQSLLQRHLCAERRLKAAQDMARKLSE---------------------------------- 683

  Fly   773 QIANDEMLPPKKRAETMHGSLAPRKSILKKTNSFNLKTYAQPMGHSPSITPYTTITGNSEFRIRS 837
                   ||...:|: :.|...|                    |..|                  
  Rat   684 -------LPYNGQAQ-LAGEWHP--------------------GGRP------------------ 702

  Fly   838 AFEAIFKKSTTLQDVQPDPETGSLSPAASNHEVEVPRTPSTPGVSKKVQLPAQSNWDFVTDQIML 902
                   :|....|...|.:.        :.:.|:|:|| ||.......||.|.           
  Rat   703 -------ESFAFVDEDEDEDV--------SRKTELPQTP-TPPPPPPPPLPPQF----------- 740

  Fly   903 QVNPISTESNKMPAEKDFTDKALSNNG--DSSKQSPSIKFKANKVADVNRSP-QTAKRCSKIRFA 964
               ||:....:.|            ||  .|.||.|    :|:..||...|. |....|      
  Rat   741 ---PIAPSYPEEP------------NGPLPSHKQPP----EASDSADQRSSIFQRLLHC------ 780

  Fly   965 NEVGVNGSPTRTKCKIKPENVLGYSIEDVDETTNPESLAESIQKPKSVRLPRERVIDMSPEDQKQ 1029
                :.|....||.||..::.                               :.|.:||||:.:.
  Rat   781 ----LLGKAHSTKKKITQDST-------------------------------DLVDNMSPEEIEA 810

  Fly  1030 WELEEMLKPIDLQKANVHIDPSPFQLVERTSILKVHSLFSMVGINHAYVTKIGRLVGVVGLKELR 1094
            ||.|::.:|:.....  .||.|||||||:|::.|.|:|||::|::.||||.:|:|.||:.|:||:
  Rat   811 WEREQLSQPVCFDFC--CIDQSPFQLVEQTTLHKTHTLFSLLGLHLAYVTSMGKLRGVLALEELQ 873

  Fly  1095 KAIE 1098
            |||:
  Rat   874 KAIK 877

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ClC-aNP_788639.1 ClC_1_like 171..646 CDD:239655 264/477 (55%)
CBS_pair_SF 659..>718 CDD:449531 30/58 (52%)
CBS repeat 664..715 CDD:341358 26/50 (52%)
CBS_pair_SF <1032..1096 CDD:449531 29/63 (46%)
CBS repeat 1053..1095 CDD:341358 23/41 (56%)
Clcn1NP_037279.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 37..61 5/28 (18%)
ClC_1_like 117..592 CDD:239655 264/477 (55%)
Selectivity filter part_1. /evidence=ECO:0000250 188..192 3/3 (100%)
Selectivity filter part_2. /evidence=ECO:0000250 230..234 3/3 (100%)
Selectivity filter part_3. /evidence=ECO:0000250 482..486 2/3 (67%)
CBS_pair_SF 605..875 CDD:449531 111/439 (25%)
CBS repeat 610..826 CDD:341358 80/385 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 710..769 21/97 (22%)
CBS repeat 832..874 CDD:341358 23/41 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 880..923
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 965..994
Blue background indicates that the domain is not in the aligned region.

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