Protein Alignment ClC-a and clh-6

DIOPT Version :10

• Sequence 1: NP_788639.1
• Gene: ClC-a / 41428
• FlyBaseID: FBgn0051116
• Length: 1193
• Species: Drosophila melanogaster
• Sequence 2: NP_506022.1
• Gene: clh-6 / 179655
• WormBaseID: WBGene00000533
• Length: 796
• Species: Caenorhabditis elegans
• Alignment Length: 724
• Identity: 192/724 - (26%)
• Similarity: 322/724 - (44%)
• Gaps: 136/724 - (18%)

  Fly    90 RDSDSSDD--DDPIGYI--------------------DTLMYGRYTKDLGEFAKDEARKLKILEK 132
            |.|.:|.|  :||:..:                    :.|::.|...|:|.....||     |..
 Worm     8 RTSSNSLDPNEDPVSGLERVMSNSNLEHVARQRRRLEEELLFSRQLDDVGRTDSHEA-----LSA 67

  Fly   133 RRKQEDKQRNKELLGKHSTRAKRVSSWIWRHTVARLGEDWVFLALLGIIMALLSFIMDKGISICT 197
            |.:..:.:.::..|.:.:.:.......:||.:..|    |....|:|:...|::..:|..:....
 Worm    68 RYESLNYEISENRLYRDAEKKPSHQLTLWRISRNR----WFVCFLIGVFTGLVAAFIDIMVHYSK 128

  Fly   198 NARI-WLYRDLTSQ------------PFVQYIAWVSLPVCLILFSAGFVHLIAPQSIGSGIPEMK 249
            :.:. |:.:.|.|:            .:...|||:.....|:..:|..|..:||.:.|||||::|
 Worm   129 DIKFNWILKYLLSKCGEEQRGTTAGCMWTVMIAWIGYNCVLVTIAAILVIYVAPIAGGSGIPQIK 193

  Fly   250 TILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLGKEGPFVHIASIVAQLLSKLVTSFQGI---- 310
            ..|.|:.:.|.:..||||:|.:|:..::|.|:..|||||.:|..:.|...:|:..:...||
 Worm   194 CYLNGIAIPEVVRLKTLVSKAVGVACSVGGGLCAGKEGPMIHSGAAVGAGISQGKSYSLGIDFGL 258

  Fly   311 ---YENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTTTYFAVRNYWRGFFAAVCGATVFRL 372
               :.|:....:.::|..|.||.|.|.||:||||||:|...:::.....||.||:|:..:.....
 Worm   259 FREFRNDREKRDFVSAGAAAGVAAAFGAPIGGVLFSLEEGASFWNQALTWRMFFSAMISSFTVNW 323

  Fly   373 LAVWFQ-NADTVRALFLTNFTT--EFPFDPQELFVFALIGLVCGLGGASYVWVHRRYVLFMRSNK 434
            :..||. .:..:....|.||..  ...::..|:.:|.|||::.|..||          ||...|.
 Worm   324 ILSWFNGRSGWLSWTGLANFGVFENKDYNIWEIPLFLLIGIIGGCLGA----------LFNYLNT 378

  Fly   435 RMNKFLQK--NRFLYPGFLALLVSSIS--------------FPLGTGQFLAGELSTHEQVTQLFS 483
            ::.:|.:|  :..|...|..|||:::|              .|:|     |...:|..|:.|:
 Worm   379 KLTEFRKKYVSSKLGRLFECLLVAAVSGFLAFLTIFAIDDCQPIG-----ANPTATSTQINQM-- 436

  Fly   484 NFTWSRDDLTVEQAAV-----------VTHWMTSYTSVFG--NLVIYTLFTFVVSIIASTIPVPS 535
               |.:..   |.:||           |.....|..:.||  .|||:.:..|::::....|.|||
 Worm   437 ---WCKKG---EYSAVASLFFQNPEESVKSMFHSPINSFGVTTLVIFGIEYFLLTLWTFGISVPS 495

  Fly   536 GMFIPVFKIGAGFGRLVGEFMAVTFPHGVRYGGRLSPIMPGGYAVVGAAA-FSGSVTHTVSVAVI 599
            |:|||....||.:|||.|.|:...||       .::.|.||.||:.|||| ..|.|..|:|:..|
 Worm   496 GVFIPAILTGAAWGRLFGIFVERLFP-------SVTGIDPGKYALAGAAAQLGGVVRMTISLTAI 553

  Fly   600 IFEMTGQITHVVPVMIAVLVANAVAALLQPSIYDSIILIKKLPYLPDLLPSSSGMYSIFVEDFMV 664
            |.|.|..||..:|:|:.::|...|..:....:||:.|.:.::|.|....|..|  .:|..:..|.
 Worm   554 IMEATKDITFGLPIMLVLMVTKWVGDMFNEGLYDAHIDLAEVPILGWNPPKMS--RNILADRVMR 616

  Fly   665 RDVKYIWHGISYQKLKEVLKLNKTLRS-----LPLVDS---------PDNMILLGSVQRYELIKM 715
            :||      ::.::.:.|.::.:.|||     .|:||.         ||...|.|.:.|.:|.|:
 Worm   617 KDV------VALERRERVSRIVEILRSTLHHGFPVVDRIEESPYESLPDYGRLKGYILRSQLFKL 675

  Fly   716 IEKHIGREK 724
            :|..|..|:
 Worm   676 LENRIFEEE 684

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	151/527 (29%)
		CBS_pair_SF	659..>718	CDD:449531	17/72 (24%)
		CBS repeat	664..715	CDD:341358	15/64 (23%)
		CBS_pair_SF	<1032..1096	CDD:449531
		CBS repeat	1053..1095	CDD:341358
clh-6	NP_506022.1	ClC_6_like	70..598	CDD:239657	154/561 (27%)
		CBS_pair_voltage-gated_CLC_euk_bac	610..775	CDD:341367	20/81 (25%)
		CBS repeat	616..727	CDD:341367	19/75 (25%)
		CBS repeat	733..775	CDD:341367