Protein Alignment ClC-a and ClC-c

DIOPT Version :10

• Sequence 1: NP_788639.1
• Gene: ClC-a / 41428
• FlyBaseID: FBgn0051116
• Length: 1193
• Species: Drosophila melanogaster
• Sequence 2: XP_061502675.1
• Gene: ClC-c / 1276446
• VectorBaseID: AGAMI1_008441
• Length: 927
• Species: Anopheles gambiae
• Alignment Length: 707
• Identity: 205/707 - (28%)
• Similarity: 315/707 - (44%)
• Gaps: 157/707 - (22%)

  Fly    92 SDSSDDDDPIGYIDTLMYGRYTKDLGEFAKDEARKLKILEKRRKQEDKQRNKELLGKHSTRAKRV 156
            :|:|||...||..:......:.:|:   |:|..|...|::||   :|...:. |.|.|
Mosquito   187 TDTSDDIPGIGQYEDFHTIDWQRDI---ARDRMRHRYIVKKR---QDSFWDL-LKGAH------- 237

  Fly   157 SSWIWRHTVARLGEDWVFLALLGIIMALLSFIMDKGIS--------ICTNARIWLYRD------- 206
            .:|          ..||.:.|:|:....::.::|.|.|        ||..| .||.|:
Mosquito   238 DAW----------SGWVCVLLVGLFTGCVAGVIDIGASWMTDLKFGICPQA-FWLNREQCCWSSN 291

  Fly   207 ------------------LTSQ---------PFVQYIAWVSLPVCLILFSAGFVHLIAPQSIGSG 244
                              .||.         .:..||.|..|   ..|.:|..|.:.||.:.|||
Mosquito   292 ETSFDSGNCSQWYAWSEIFTSSREGFGAYVISYFFYIMWAML---FALLAASLVRMFAPYACGSG 353

  Fly   245 IPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLGKEGPFVHIASIVAQLLSKLVTSFQG 309
            |||:||||.|..::.||...||:.|.:|:..::.:|:.||||||.|||||.:..:||.|   |..
Mosquito   354 IPEIKTILSGFIIRSYLGKWTLIIKSVGIMLSVSAGLSLGKEGPMVHIASCIGNILSYL---FPK 415

  Fly   310 IYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTTTYFAVRNYWRGFFAAVCGATVFRLLA 374
            ...||::..|:|:||.|.||...|.||:||||||:|..:.||.::..||.||.|:..|.:.|.:.
Mosquito   416 YGRNEAKKREILSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFCALIAAFILRSIN 480

  Fly   375 VWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLVCGLGGASYVWVHRRYVLFMRSNK---RM 436
            . |.|..:|  ||...:...:.|  .||..|..:|::.|:..          .||:::|.   |.
Mosquito   481 P-FGNEHSV--LFYVEYNKPWIF--FELVPFIGLGIIGGIIA----------TLFIKANLWWCRF 530

  Fly   437 NKFLQKNRFLYPGFLALLVSSISFPLGTGQFLAGELSTHEQVTQLFS---------------NFT 486
            .|:.:..:  ||....|:|:.|:..:....... .::|.|.:..|||               |||
Mosquito   531 RKYSKLGQ--YPVTEVLIVTFITAVIAYPNPYT-RMNTSELIYLLFSQCGISNQDPLCDYNRNFT 592

  Fly   487 WSRDDLTVEQAAVVTH---WMTSYTSVFGNLVIYTLFTFVVSIIASTIPVPSGMFIPVFKIGAGF 548
            .....:.:..|....:   |:         |::......:::|....:.||.|:|||...:||..
Mosquito   593 DVNSAIEIAAAGPGVYKAVWL---------LILALAMKLIMTIFTFGMKVPCGLFIPSLALGAIT 648

  Fly   549 GRLVG---EFMAVTFPHGVRYGGRLSP----IMPGGYAVVGAAAFSGSVTH-TVSVAVIIFEMTG 605
            ||:||   |.:|..:|....:.|..|.    |.||.||:|||||..|.||. |||:.||:||:||
Mosquito   649 GRIVGIAMEQLAYNYPKIWIFSGECSTGDDCITPGLYAMVGAAAVLGGVTRMTVSLVVIMFELTG 713

  Fly   606 QITHVVPVMIAVLVANAVA-ALLQPSIYDSIILIKKLPYLPD-------------LLPSSSGMYS 656
            .:.::||:|.|.:.:..|. ||.:..|||:.|.:...|:|..             :.|..:...:
Mosquito   714 GVRYIVPLMAAAMASKWVGDALGRQGIYDAHIALNGYPFLDSKDEFQHTTLAADVMQPKRNETLA 778

  Fly   657 IFVEDFM-VRDVKYIWHGISYQKLKEVLKLNKTLRSLPLVDSPDNMILLGSVQRYEL 712
            :..:|.| |.|::.:        |||.     .....|:|.|.:|..|:|.|.|.:|
Mosquito   779 VITQDSMTVDDIETL--------LKET-----EHNGYPVVVSKENQYLVGFVLRRDL 822

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	170/546 (31%)
		CBS_pair_SF	659..>718	CDD:449531	16/55 (29%)
		CBS repeat	664..715	CDD:341358	14/49 (29%)
		CBS_pair_SF	<1032..1096	CDD:449531
		CBS repeat	1053..1095	CDD:341358
ClC-c	XP_061502675.1	None