Protein Alignment ClC-a and Clcnka

DIOPT Version :10

• Sequence 1: NP_788639.1
• Gene: ClC-a / 41428
• FlyBaseID: FBgn0051116
• Length: 1193
• Species: Drosophila melanogaster
• Sequence 2: NP_077723.3
• Gene: Clcnka / 12733
• MGIID: 1329026
• Length: 687
• Species: Mus musculus
• Alignment Length: 667
• Identity: 256/667 - (38%)
• Similarity: 394/667 - (59%)
• Gaps: 46/667 - (6%)

  Fly   159 WIWRHTVARLGEDWVFLALLGIIMALLSFIMDKGISICTNARIWLYRDLTSQPFVQYIAWVSLPV 223
            |: :..:.|..|||.||..||::|||:|:.|:..|.....|..||||::.....::|::|...||
Mouse    38 WL-KERLFRAREDWYFLVALGVLMALISYAMNFAIGRVVRAHKWLYREVGDGHLLRYLSWTVYPV 101

  Fly   224 CLILFSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATL--GSGMPLGKE 286
            .|:.||:||...|.|.|.|||:||:||:|.||.|:.||..|...|||:||:.||  ||.:.|||.
Mouse   102 ALLSFSSGFSQSITPFSGGSGLPELKTMLSGVVLENYLDIKNFGAKVVGLSCTLATGSTIFLGKV 166

  Fly   287 GPFVHIASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTTTYF 351
            |||||::.:::..|.::.....|..|::::..|||:||.||||...||||..||||||||.:::|
Mouse   167 GPFVHLSVMISAYLGRVRAKAVGDTESKAKEVEMLSAAAAVGVATVFAAPFSGVLFSIEVMSSHF 231

  Fly   352 AVRNYWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLVCGLGG 416
            :|.|||||||||.|||.:||||||:....:|:.:::.|.|..:.|||..|:|.|..:|.:||:..
Mouse   232 SVWNYWRGFFAATCGAFMFRLLAVFNSEQETITSIYKTRFRVDVPFDLPEIFFFVALGFICGILS 296

  Fly   417 ASYVWVHRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSSISFPLGTGQFLAGELSTHEQVTQL 481
            ..|::..|.::.|:::|:..:|.|..::..|...:||:::|:::|.|.|:|:|..||..|.:..|
Mouse   297 CVYLFCQRNFLRFIKTNRYTSKLLATSKPSYAALVALVLASVTYPPGVGRFMASRLSMAEHLHSL 361

  Fly   482 FSNFTWSRDDLTVEQAA-----------VVTHWMTSYTSVFGNLVIYTLFTFVVSIIASTIPVPS 535
            |.|.:|:   |....|:           :...|.....::||.|..:.:..|.:.|:|:|||:|:
Mouse   362 FDNNSWA---LMTRNASPPWPSEPDPQNLWFEWYHPRFTIFGTLAFFLIMKFWMLILATTIPMPA 423

  Fly   536 GMFIPVFKIGAGFGRLVGEFMAVTFPHGVRYGGRLSPIMPGGYAVVGAAAFSGSVTHTVSVAVII 600
            |.|:|:|.|||..|||:||.::|.||.|:..||.:.||||||||:.|||||||:||||:|.|::.
Mouse   424 GYFMPIFIIGAAIGRLLGEALSVAFPEGIVAGGEVYPIMPGGYALAGAAAFSGAVTHTISTALLA 488

  Fly   601 FEMTGQITHVVPVMIAVLVANAVAALLQPSIYDSIILIKKLPYLPDLLPSSSGMYSIFVEDFMVR 665
            ||:||||.|.:||::|||.||.::..||||.||..|:.|||||||.:.....|.|.:.||.||..
Mouse   489 FELTGQIVHALPVLMAVLAANVISQNLQPSFYDGTIMAKKLPYLPWIRGRQIGSYPVTVEHFMNS 553

  Fly   666 DVKYIWHGISYQKLKEVLKL--NKTLRSLPLVDSPDNMILLGSVQRYELIKMIEKHIGREKRMEV 728
            ::..:   .....|:||:|:  :..:...|||::.::..|:|.|:|..|::.::..
Mouse   554 NLTTL---AKDMPLEEVVKVVTSTDVSQYPLVETRESQTLVGIVERTHLVQALQTQ--------- 606

  Fly   729 AQKWQKEAQERALEE----EKKKQEVELKMR-RPSRFEVLPAPDILSL---------RQIANDEM 779
            ...| ...|||.|::    ....|.|.|::. ..|.::.....::|:|         |.:.:...
Mouse   607 PASW-APGQERFLQDILAGGCPTQPVTLQLSPETSLYQAHRLFELLTLQALFVTSRGRAVGSVSW 670

  Fly   780 LPPKKRAETMHGSLAPR 796
            :..||...|:....||:
Mouse   671 VELKKAISTLINPPAPK 687

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	217/487 (45%)
		CBS_pair_SF	659..>718	CDD:449531	16/60 (27%)
		CBS repeat	664..715	CDD:341358	12/52 (23%)
		CBS_pair_SF	<1032..1096	CDD:449531
		CBS repeat	1053..1095	CDD:341358
Clcnka	NP_077723.3	ClC_1_like	49..533	CDD:239655	216/486 (44%)
		CBS_pair_voltage-gated_CLC_euk_bac	546..676	CDD:341367	29/142 (20%)
		CBS repeat	552..627	CDD:341367	17/87 (20%)
		CBS repeat	633..675	CDD:341367	5/41 (12%)