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Protein Alignment ClC-a and Clcn3

DIOPT Version :10

Sequence 1:	NP_788639.1	Gene:	ClC-a / 41428	FlyBaseID:	FBgn0051116	Length:	1193	Species:	Drosophila melanogaster
Sequence 2:	NP_776299.1	Gene:	Clcn3 / 12725	MGIID:	103555	Length:	866	Species:	Mus musculus

Alignment Length:	935	Identity:	248/935 - (26%)
Similarity:	371/935 - (39%)	Gaps:	275/935 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 DSDSSDDDDPIGYIDTLMYGRYTKDLGEFAKDEARKLKILEK-----------------RRKQED 138
            |..:|:||:.:.. ||.....||...|.........|.:|::                 |.|.:|
Mouse    37 DFQTSEDDNLLDG-DTAAGTHYTMTNGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKD 100

  Fly   139 KQRNKELLGKHSTRAKRVSSWIWRHTVARLGEDWVFLALLGIIMALLSFIMDKGI--------SI 195
            ::|::.:..|     |:.|:|....::......|:.:.|.|:....|:.::|...        .|
Mouse   101 RERHRRINSK-----KKESAWEMTKSLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGI 160

  Fly   196 CTNARIWL---------------YRDLTSQ--------------------PFVQYIAWVSLPVCL 225
            |.:| :|.               .||...|                    .::.||.|.   :..
Mouse   161 CLSA-LWYNHEQCCWGSNETTFEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWA---LSF 221

  Fly   226 ILFSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLGKEGPFV 290
            ...:...|.:.||.:.||||||:||||.|..::.||...||:.|.|.|...:.||:.||||||.|
Mouse   222 AFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLV 286

  Fly   291 HIASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTTTYFAVRN 355
            |:|.....:.|.|...:.   .||::..|:|:||.|.||...|.||:||||||:|..:.||.::.
Mouse   287 HVACCCGNIFSYLFPKYS---TNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKT 348

  Fly   356 YWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLVCGLGGASYV 420
            .||.||||:..|.|.|.:.. |.|:..|  ||...:.|  |:...|||.|.|:|:..||.||.::
Mouse   349 LWRSFFAALVAAFVLRSINP-FGNSRLV--LFYVEYHT--PWYLFELFPFILLGVFGGLWGAFFI 408

  Fly   421 -----WVHRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSS----ISFPLGTGQFLAGELSTHE 476
                 |..||         :..||.:     ||....::|::    |:||....:     |:|.|
Mouse   409 RANIAWCRRR---------KSTKFGK-----YPVLEVIIVAAITAVIAFPNPYTR-----LNTSE 454

  Fly   477 QVTQLFS-----------------NFTWSRDDLTVEQAAVVTH---WMTSYTSVFGNLVIYTLFT 521
            .:.:||:                 |.:...||:....|.|..:   |......:|  .:|.|:||
Mouse   455 LIKELFTDCGPLESSSLCDYRNDMNASKIVDDIPDRPAGVGVYSAIWQLCLALIF--KIIMTVFT 517

  Fly   522 FVVSIIASTIPVPSGMFIPVFKIGAGFGRLVG---EFMA------VTFPHGVRYGGRLSPIMPGG 577
            |       .|.||||:|||...|||..||:||   |.:|      ..|......|.  ..|.||.
Mouse   518 F-------GIKVPSGLFIPSMAIGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVGA--DCITPGL 573

  Fly   578 YAVVGAAAFSGSVTH-TVSVAVIIFEMTGQITHVVPVMIAVLVANAVA-ALLQPSIYDSIILIKK 640
            ||:|||||..|.||. |||:.||:||:||.:.::||:|.||:.:..|. |..:..||::.|.:..
Mouse   574 YAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNG 638

  Fly   641 LPYL------------PDLL--PSSSGMYSIFVEDFM-VRDVKYIWHGISYQKLKEVLKLNKTLR 690
            .|:|            .|::  ..|....::..:|.| |.|::.:.:..||             .
Mouse   639 YPFLDAKEEFTHTTLAADVMRPRRSDPPLAVLTQDNMTVDDIENMINETSY-------------N 690

  Fly   691 SLPLVDSPDNMILLGSVQRYELIKMIEKHIGREKRMEVAQKWQKEAQERALEEEKKKQE------ 749
            ..|::.|.::..|:|...|.:|                         ..|:|..:||||
Mouse   691 GFPVIMSKESQRLVGFALRRDL-------------------------TIAIESARKKQEGIVGSS 730

  Fly   750 -VELKMRRPSRFEVLPA--PDILSLRQIANDEMLP-------PKKRAETMHGSLAPRK------- 797
             |......||    |||  |..|.||.|.  :|.|       |.:....:...|..|:
Mouse   731 RVCFAQHTPS----LPAESPRPLKLRSIL--DMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHNG 789

  Fly   798 ---SILKKTNSF----NLKTYAQPM---------GHSPSITPYTTITGNSEFRIRSAFEAIFKKS 846
               .|:.|.|..    .||.:.:|:         .:.||..|
Mouse   790 IVLGIITKKNILEHLEQLKQHVEPLTPPWHYNKKRYPPSYGP----------------------- 831

  Fly   847 TTLQDVQPDPETGS--LSPAASNHE 869
                |.:|.|...:  |||...:.|
Mouse   832 ----DGKPRPRFNNVQLSPVDEDRE 852

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.