DRSC/TRiP Functional Genomics Resources

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Protein Alignment ClC-a and Clcn2

DIOPT Version :10

Sequence 1:NP_788639.1 Gene:ClC-a / 41428 FlyBaseID:FBgn0051116 Length:1193 Species:Drosophila melanogaster
Sequence 2:NP_001403697.1 Gene:Clcn2 / 12724 MGIID:105061 Length:915 Species:Mus musculus


Alignment Length:1101 Identity:453/1101 - (41%)
Similarity:602/1101 - (54%) Gaps:231/1101 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   103 YIDTLMYGRYTKDLGEFAKDEARKLKI--LEKRRKQEDKQRNKELLGKHSTRAKR---VSSWIWR 162
            |..||||||||::||.|||:||.::::  .|..:.....:...|||....:|..|   .|....:
Mouse    25 YEQTLMYGRYTQELGAFAKEEAARIRLGGPEPWKGSPSARATPELLEYGQSRCARCRICSVRCHK 89

  Fly   163 HTVARLGEDWVFLALLGIIMALLSFIMDKGISICT-------NARIWLYRDLTSQPFVQYIAWVS 220
            ..|:|:||||:||.|||::|||:|:.||..|::|.       .|:.|:.|.|.:...:||:|||:
Mouse    90 FLVSRVGEDWIFLVLLGLLMALVSWAMDYAIAVCLQGEGKGWRAQQWMSRGLNTNILLQYLAWVT 154

  Fly   221 LPVCLILFSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLGK 285
            .||.||.|||||..::|||::||||||||||||||.||||||.||.||||||||..|||||||||
Mouse   155 YPVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFVAKVIGLTCALGSGMPLGK 219

  Fly   286 EGPFVHIASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTTTY 350
            |||||||||:.|.||||.::.|.||||:||||:||||||||||||.|||||:||||||||||:|:
Mouse   220 EGPFVHIASMCAALLSKFLSLFGGIYEHESRNTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTF 284

  Fly   351 FAVRNYWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLVCGLG 415
            |||||||||||||...|.:||:||||.::.:|:.|||.|.|..:||||.|||..||:||:..|.|
Mouse   285 FAVRNYWRGFFAATFSAFIFRVLAVWNRDEETITALFKTRFRLDFPFDLQELPAFAVIGIASGFG 349

  Fly   416 GASYVWVHRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSSISFPLGTGQFLAGELSTHEQVTQ 480
            ||.:|:::|:.|..||..|.:|:||.:.|.|:|..:.||:|:::||.|.|||:||:||..|.:..
Mouse   350 GALFVYLNRKIVQVMRKQKTINRFLMRKRLLFPALVTLLISTLTFPPGFGQFMAGQLSQKETLVT 414

  Fly   481 LFSNFTWSRDDLT--VEQAAVVTHWMTSYTSVFGNLVIYTLFTFVVSIIASTIPVPSGMFIPVFK 543
            ||.|.||.|..|.  :|..:....|.....:||..|||:.|..|.:|.:|:|||||.|.|:|||.
Mouse   415 LFDNRTWVRQGLVEDLELPSTSQAWSPPRANVFLTLVIFILMKFWMSALATTIPVPCGAFMPVFV 479

  Fly   544 IGAGFGRLVGEFMAVTFPHGVRYGGRLSPIMPGGYAVVGAAAFSGSVTHTVSVAVIIFEMTGQIT 608
            |||.|||||||.||..||.|:........|:|||||||||||.:|:||||||.|||:||:||||.
Mouse   480 IGAAFGRLVGESMAAWFPDGIHTDSSTYRIVPGGYAVVGAAALAGAVTHTVSTAVIVFELTGQIA 544

  Fly   609 HVVPVMIAVLVANAVAALLQPSIYDSIILIKKLPYLPDLLPSSSGMYSIFVEDFMVRDVKYIWHG 673
            |::||||||::|||||..||||:|||||.||||||||:|.......|.:.|||.|||||.::...
Mouse   545 HILPVMIAVILANAVAQSLQPSLYDSIIRIKKLPYLPELGWGRHQQYRVRVEDIMVRDVPHVALS 609

  Fly   674 ISYQKLKEVLKLNKTL-RSLPLVDSPDNMILLGSVQRYELIKMIEKHIGREKRMEVAQKWQKEAQ 737
            .:::.|:  |.|::|. |.|.||:||::||||||::|.:::.::...:...:|.:..||.:|   
Mouse   610 CTFRDLR--LALHRTKGRMLALVESPESMILLGSIERSQVVALLGAQLSPARRRQHMQKLRK--- 669

  Fly   738 ERALEEEKKKQEVELKMRRPSRFEVLPAPDILSLRQIANDEMLPPKKRAETMHGSL-APRKSILK 801
                          .::..||..|..|:.: .|:|...|.|    .......||.. .|.|..||
Mouse   670 --------------AQLSPPSDQESPPSSE-TSIRFQVNTE----DSGFSGAHGQTHKPLKPALK 715

  Fly   802 KTNSFNLKTYAQPMGHSPSITPYTTITGNSE---FRIRSAFEAIFKKSTTLQDVQPDPETGSLSP 863
            :             |.|.|.:.....|||.|   ..:||.|                  .|| .|
Mouse   716 R-------------GPSNSTSLQEGTTGNMESAGIALRSLF------------------CGS-PP 748

  Fly   864 AASNHEVEVPRTPSTPGVSKKVQLPAQSNWDFVTDQIMLQVNPISTESNKMPAEKDFTDKALSNN 928
            ..:..|:|                                                         
Mouse   749 LEATSELE--------------------------------------------------------- 756

  Fly   929 GDSSKQSPSIKFKANKVADVNRSPQTAKRCSKIRFANEVGVNGSPTRTKCKIKPENVLGYSIEDV 993
                |.....|.|..:|              :|..|::                           
Mouse   757 ----KSESCDKRKLKRV--------------RISLASD--------------------------- 776

  Fly   994 DETTNPESLAESIQKPKSVRLPRERVIDMSPEDQKQWELEEMLKPIDLQKANVHIDPSPFQLVER 1058
               ::||:                   :||||:..:||.:::.:|::.  ::..|||:|||||||
Mouse   777 ---SDPEA-------------------EMSPEEILEWEEQQLDEPVNF--SDCKIDPAPFQLVER 817

  Fly  1059 TSILKVHSLFSMVGINHAYVTKIGRLVGVVGLKELRKAIEDINSNSFVPPTRDEDADEKPAVEKP 1123
            ||:.|.|::||::|::|||||.||||:|:|.|||||||||...:...|            .|..|
Mouse   818 TSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKELRKAIEGSVTAQGV------------KVRPP 870

  Fly  1124 LLSTNSSDKAVDMTVTSMDSALSNSENCSDIEMEHIKHTDKGTVSLTMPPQESKQSPSADK 1184
            |.|..             |||.|:    ||.|...: |...|..|....|:|...|.|.||
Mouse   871 LASFR-------------DSATSS----SDTETTEV-HALWGPRSRHGLPREGTPSDSDDK 913

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
ClC-aNP_788639.1 ClC_1_like 171..646 CDD:239655 292/483 (60%)
CBS_pair_SF 659..>718 CDD:449531 25/59 (42%)
CBS repeat 664..715 CDD:341358 21/51 (41%)
CBS_pair_SF <1032..1096 CDD:449531 34/63 (54%)
CBS repeat 1053..1095 CDD:341358 28/41 (68%)
Clcn2NP_001403697.1 Essential for channel gating by both voltage and cell volume. /evidence=ECO:0000250|UniProtKB:P35525 24..42 11/16 (69%)
Modulates channel gating by both voltage and cell volume. /evidence=ECO:0000250|UniProtKB:P35525 44..57 3/12 (25%)
ClC_1_like 98..582 CDD:239655 292/483 (60%)
Selectivity filter part_1. /evidence=ECO:0000250 176..180 3/3 (100%)
Selectivity filter part_2. /evidence=ECO:0000250 218..222 3/3 (100%)
Selectivity filter part_3. /evidence=ECO:0000250 472..476 2/3 (67%)
CBS_pair_voltage-gated_CLC_euk_bac 594..855 CDD:341367 106/442 (24%)
CBS repeat 600..806 CDD:341367 69/387 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 660..729 21/103 (20%)
CBS repeat 812..854 CDD:341367 28/41 (68%)