Protein Alignment ClC-a and Clcn1

DIOPT Version :10

• Sequence 1: NP_788639.1
• Gene: ClC-a / 41428
• FlyBaseID: FBgn0051116
• Length: 1193
• Species: Drosophila melanogaster
• Sequence 2: NP_038519.1
• Gene: Clcn1 / 12723
• MGIID: 88417
• Length: 994
• Species: Mus musculus
• Alignment Length: 1106
• Identity: 413/1106 - (37%)
• Similarity: 584/1106 - (52%)
• Gaps: 239/1106 - (21%)

  Fly    69 QRH----------PKIKSHAFYPCPP---PAENA-------RDSDSSDDDDPIGYIDTLMYGRYT 113
            |||          |:.:...|..|..   |:||.       :|.....:..|     |.:||...
Mouse     7 QRHGGEQSWWGSAPQYQYMPFEHCTSYGLPSENGGLQHRPRKDMGPRHNAHP-----TQIYGHQK 66

  Fly   114 KDLGEFAKDEARKLKILEKRRKQEDKQRNKELLGKHSTRAKRVSSWIWRHTVARLGEDWVFLALL 178
            :.....|:|....       :|.........|...|.::.:.....:.|....:|||||:||.||
Mouse    67 EQYSYKAQDGGMP-------KKMGSSSTMDSLDEDHYSKCQDCVHRLGRVLRRKLGEDWIFLVLL 124

  Fly   179 GIIMALLSFIMDKGISICTNARIWLYRDLTSQPFVQYIAWVSLPVCLILFSAGFVHLIAPQSIGS 243
            |::|||:|:.||...:....|..|.|..:.....:||:|||:.|:.||||||.|..||:||::||
Mouse   125 GLLMALVSWCMDYVSAKSLQAYKWTYAQMKPSLPLQYLAWVTFPLILILFSALFCQLISPQAVGS 189

  Fly   244 GIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLGKEGPFVHIASIVAQLLSKLVTSFQ 308
            ||||||||||||.||||||.|..||||:.|||.||||:|:||||||||||||.|.:|||.::.|.
Mouse   190 GIPEMKTILRGVVLKEYLTLKAFVAKVVALTAGLGSGIPVGKEGPFVHIASICAAVLSKFMSMFS 254

  Fly   309 GIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTTTYFAVRNYWRGFFAAVCGATVFRLL 373
            |:||.....:::|...||||||.||..|:||||||||||:|||||||||||||||...|.|||:|
Mouse   255 GVYEQPYYYTDILTVGCAVGVGCCFGTPLGGVLFSIEVTSTYFAVRNYWRGFFAATFSAFVFRVL 319

  Fly   374 AVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLVCGLGGASYVWVHRRYVLFMRSNKRMNK 438
            |||.::|.|:.|||.|||..:||||.:||..||:||:.||..||.:|::||:.:|.:|.:|.:::
Mouse   320 AVWNKDAVTITALFRTNFRMDFPFDLKELPAFAVIGICCGFLGAVFVYLHRQVMLGVRKHKCLSQ 384

  Fly   439 FLQKNRFLYPGFLALLVSSISFPLGTGQFLAGELSTHEQVTQLFSNFTWSR---DDLTVEQAAVV 500
            ||.|:|.||||.:..:::|::||.|.|||:||||...|.::.||.|.||.:   |..::.|:||
Mouse   385 FLAKHRLLYPGIVTFVIASLTFPPGMGQFMAGELMPREAISTLFDNNTWVKHIGDPQSLGQSAV- 448

  Fly   501 THWMTSYTSVFGNLVIYTLFTFVVSIIASTIPVPSGMFIPVFKIGAGFGRLVGEFMAVTFPHGVR 565
              |:....:|...::::.:..|.:||:|:|:|:|.|.|:|||.:||.|||||||.||:.||.|:.
Mouse   449 --WLHPQVNVIIIILLFFVMKFWMSIVATTMPIPCGGFMPVFVLGAAFGRLVGEIMAMLFPEGIL 511

  Fly   566 YGGRLSPIMPGGYAVVGAAAFSGSVTHTVSVAVIIFEMTGQITHVVPVMIAVLVANAVAALLQPS 630
            :...:..|:||||||:||||.:|:|:||||.|||.||:||||.|::|:|:||::||.||..||||
Mouse   512 FDDIIYKILPGGYAVIGAAALTGAVSHTVSTAVICFELTGQIAHILPMMVAVILANMVAQSLQPS 576

  Fly   631 IYDSIILIKKLPYLPDLLPSSSGMYSIFVEDFMVRDVKYIWHGISYQKLKEVLKLNKTLRSLPLV 695
            :|||||.:|||||||||..:....::|||||.||||||::....:|.:|:.:|:.. |:::||||
Mouse   577 LYDSIIQVKKLPYLPDLGWNQLSKFTIFVEDIMVRDVKFVSASCTYGELRNLLQAT-TVKTLPLV 640

  Fly   696 DSPDNMILLGSVQRYELIKMIEKHIGREKRMEVAQKWQKEAQERALEEEKKKQEVELKMRRPSRF 760
            ||.|:|||||||:|.||..::::|:..|:|::.||...::..|
Mouse   641 DSKDSMILLGSVERSELQSLLQRHLCAERRLKAAQDMARKLSE---------------------- 683

  Fly   761 EVLPAPDILSLRQIANDEMLPPKKRAETMHGSLAPRKSILKKTNSFNLKTYAQPMGHSPSITPYT 825
                               ||...:|: :.|...|                    |..|
Mouse   684 -------------------LPYNGKAQ-LAGDWHP--------------------GGRP------ 702

  Fly   826 TITGNSEFRIRSAFEAIFKKSTTLQDVQPDPETGSLSPAASNHEVEVPRTPSTPGVSKKVQLPAQ 890
                               :|....|...|.:.        :.::|:|.||:.|..|..   |..
Mouse   703 -------------------ESFAFVDEDEDEDL--------SRKMELPLTPAPPPPSPP---PPP 737

  Fly   891 SNWDFVTDQIMLQVNPISTESNKMPAEKDFTDKALSNNG--DSSKQSPSIKFKANKVADVNRSP- 952
            |.:            ||:..:.:.|            ||  .|.||.|    :|:..||...|.
Mouse   738 SQF------------PIAPSNPEEP------------NGPLPSHKQPP----EASDSADQRSSTF 774

  Fly   953 QTAKRCSKIRFANEVGVNGSPTRTKCKIKPENVLGYSIEDVDETTNPESLAESIQKPKSVRLPRE 1017
            |....|                                          .|.::..|.|.:.....
Mouse   775 QRLLHC------------------------------------------LLGKAHSKKKKITQDST 797

  Fly  1018 RVID-MSPEDQKQWELEEMLKPIDLQKANVHIDPSPFQLVERTSILKVHSLFSMVGINHAYVTKI 1081
            .::| ||||:.:.||.|::.:|:.....  .||.|||||||:|::.|.|:|||::|::.||||.:
Mouse   798 DLVDNMSPEEIEAWEREQLSQPVCFDCC--CIDQSPFQLVEQTTLHKTHTLFSLLGLHLAYVTSM 860

  Fly  1082 GRLVGVVGLKELRKAIED---------------INSNSF------VPPTRD-----EDADEKPAV 1120
            |:|.||:.|:||:||||.               .|:.|.      .||..:     ||.|..|..
Mouse   861 GKLRGVLALEELQKAIEGHTKSGVQLRPPLASFRNTTSIRKTPGGPPPPAEGWNVPEDGDGAPGR 925

  Fly  1121 E 1121
            |
Mouse   926 E 926

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	264/477 (55%)
		CBS_pair_SF	659..>718	CDD:449531	30/58 (52%)
		CBS repeat	664..715	CDD:341358	26/50 (52%)
		CBS_pair_SF	<1032..1096	CDD:449531	29/63 (46%)
		CBS repeat	1053..1095	CDD:341358	23/41 (56%)
Clcn1	NP_038519.1	ClC_1_like	117..592	CDD:239655	264/477 (55%)
		Selectivity filter part_1. /evidence=ECO:0000250	188..192		3/3 (100%)
		Selectivity filter part_2. /evidence=ECO:0000250	230..234		3/3 (100%)
		Selectivity filter part_3. /evidence=ECO:0000250	482..486		2/3 (67%)
		CBS_pair_SF	605..875	CDD:449531	108/440 (25%)
		CBS repeat	610..826	CDD:341358	77/386 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	710..770		21/98 (21%)
		CBS repeat	832..874	CDD:341358	23/41 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	886..954		9/41 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	971..994