DRSC/TRiP Functional Genomics Resources

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Protein Alignment ClC-a and CLCNKA

DIOPT Version :10

Sequence 1:NP_788639.1 Gene:ClC-a / 41428 FlyBaseID:FBgn0051116 Length:1193 Species:Drosophila melanogaster
Sequence 2:NP_004061.3 Gene:CLCNKA / 1187 HGNCID:2026 Length:687 Species:Homo sapiens


Alignment Length:593 Identity:258/593 - (43%)
Similarity:382/593 - (64%) Gaps:25/593 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly   143 KELLG--KHSTRAKRVS-SWIWRHTVARLGEDWVFLALLGIIMALLSFIMDKGISICTNARIWLY 204
            :||.|  .|..||.:.. .|: :..|.||||||.||..||::|||:|:.|:..|.....|..|||
Human    19 QELWGPCPHIRRAIQGGLEWL-KQKVFRLGEDWYFLMTLGVLMALVSYAMNFAIGCVVRAHQWLY 82

  Fly   205 RDLTSQPFVQYIAWVSLPVCLILFSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAK 269
            |::.....::|::|...||.|:.||:||...|.|.|.||||||:||:|.||.|::||..|...||
Human    83 REIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAK 147

  Fly   270 VIGLTATL--GSGMPLGKEGPFVHIASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGAC 332
            |:||:.||  ||.:.|||.|||||::.::|..|.::.|:..|..||:|:.:|||.||.||||...
Human   148 VVGLSCTLATGSTLFLGKVGPFVHLSVMIAAYLGRVRTTTIGEPENKSKQNEMLVAAAAVGVATV 212

  Fly   333 FAAPVGGVLFSIEVTTTYFAVRNYWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPF 397
            ||||..||||||||.:::|:||:||||||||.|||.:||||||:....:|:.:|:.|:|..:.||
Human   213 FAAPFSGVLFSIEVMSSHFSVRDYWRGFFAATCGAFIFRLLAVFNSEQETITSLYKTSFRVDVPF 277

  Fly   398 DPQELFVFALIGLVCGLGGASYVWVHRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSSISFPL 462
            |..|:|.|..:|.:||:...:|::..|.::.|:::|:..:|.|..::.:|.....||::||::|.
Human   278 DLPEIFFFVALGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATSKPVYSALATLLLASITYPP 342

  Fly   463 GTGQFLAGELSTHEQVTQLFSNFTWSRDDLTVEQAA-----------VVTHWMTSYTSVFGNLVI 516
            |.|.|||..||..:.:..||.|.:|:   |..:.::           :...|.....::||.|..
Human   343 GVGHFLASRLSMKQHLDSLFDNHSWA---LMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAF 404

  Fly   517 YTLFTFVVSIIASTIPVPSGMFIPVFKIGAGFGRLVGEFMAVTFPHGVRYGGRLSPIMPGGYAVV 581
            :.:..|.:.|:|:|||:|:|.|:|:|.:||..|||:||.:||.||.|:..||..:||||||||:.
Human   405 FLVMKFWMLILATTIPMPAGYFMPIFILGAAIGRLLGEALAVAFPEGIVTGGVTNPIMPGGYALA 469

  Fly   582 GAAAFSGSVTHTVSVAVIIFEMTGQITHVVPVMIAVLVANAVAALLQPSIYDSIILIKKLPYLPD 646
            |||||||:||||:|.|::.||:||||.|.:||::|||.|||:|...|||.||..|::|||||||.
Human   470 GAAAFSGAVTHTISTALLAFELTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTIIVKKLPYLPR 534

  Fly   647 LLPSSSGMYSIFVEDFMVRDVKYIWHGISYQKLKEVLKL--NKTLRSLPLVDSPDNMILLGSVQR 709
            :|..:.|.:.:.||.||...:..:   .....|:||:|:  :..:...|||:|.::.||:|.|||
Human   535 ILGRNIGSHHVRVEHFMNHSITTL---AKDTPLEEVVKVVTSTDVTEYPLVESTESQILVGIVQR 596

  Fly   710 YELIKMIE 717
            .:|::.::
Human   597 AQLVQALQ 604

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ClC-aNP_788639.1 ClC_1_like 171..646 CDD:239655 224/487 (46%)
CBS_pair_SF 659..>718 CDD:449531 19/61 (31%)
CBS repeat 664..715 CDD:341358 15/52 (29%)
CBS_pair_SF <1032..1096 CDD:449531
CBS repeat 1053..1095 CDD:341358
CLCNKANP_004061.3 ClC_1_like 49..534 CDD:239655 224/487 (46%)
CBS_pair_voltage-gated_CLC_euk_bac 546..676 CDD:341367 19/62 (31%)
CBS repeat 552..627 CDD:341367 15/56 (27%)
CBS repeat 633..675 CDD:341367
Blue background indicates that the domain is not in the aligned region.

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