DRSC/TRiP Functional Genomics Resources

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Protein Alignment ClC-a and CLCN7

DIOPT Version :10

Sequence 1:NP_788639.1 Gene:ClC-a / 41428 FlyBaseID:FBgn0051116 Length:1193 Species:Drosophila melanogaster
Sequence 2:NP_001278.1 Gene:CLCN7 / 1186 HGNCID:2025 Length:805 Species:Homo sapiens


Alignment Length:792 Identity:200/792 - (25%)
Similarity:336/792 - (42%) Gaps:174/792 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   119 FAKDEARKLKILEKRRKQEDKQRNKELLGKHSTRAKRVSSWIWRHTVARLGE--DWVFLALLGII 181
            |.|:.....|:|..:.:..|...::..|.....|  |::     ||..|..|  .||..||:||:
Human    79 FPKEIPHNEKLLSLKYESLDYDNSENQLFLEEER--RIN-----HTAFRTVEIKRWVICALIGIL 136

  Fly   182 MALLSFIMDKGISICTNARIWLYRDLTS--QPFVQ-------YIAWVSLPVCLILFSAGFVHLIA 237
            ..|::..:|   .:..|.....||.:..  ..|.:       .:.|.:|....:|..:..|..|.
Human   137 TGLVACFID---IVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWATLNAAFVLVGSVIVAFIE 198

  Fly   238 PQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLGKEGPFVHIASIVAQLLSK 302
            |.:.|||||::|..|.||::...:..||||.||.|:..::..|:.:|||||.:|..|::|..:|:
Human   199 PVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQ 263

  Fly   303 -----LVTSFQGIYENESRNSE---MLAAACAVGVGACFAAPVGGVLFSIEVTTTYFAVRNYWRG 359
                 |...|: |:|...|::|   .::|..|.||.|.|.|||||||||:|...:::.....||.
Human   264 GRSTSLKRDFK-IFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRI 327

  Fly   360 FFAAVCGA-TVFRLLAVWFQNADTVRALFLTNF----TTEFPFDPQELFVFALIGLVCGLGGASY 419
            |||::... |:..:|:::..|...:.:..|.||    :.:..:...|:.||..:|:|.|:.||  
Human   328 FFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGA-- 390

  Fly   420 VWVHRRYVLFMRSNKRMNKFLQKNRFLYPGFL----ALLVS-----------------------S 457
                    :|...|..:..|  :.|:::...|    |:||:                       |
Human   391 --------VFNALNYWLTMF--RIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGS 445

  Fly   458 ISFPL----GTGQF---LAGELSTHEQ-VTQLFSNFTWSRDDLTVEQAAVVTHWMTSYTSVFGNL 514
            :|:||    ..|::   .|...:|.|: |..||.:...|.:.||                    |
Human   446 MSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLT--------------------L 490

  Fly   515 VIYTLFTFVVSIIASTIPVPSGMFIPVFKIGAGFGRLVGEFMAVTFPHGVRYGGRLSPIMPGGYA 579
            .::||..|.::.....:.|.:|:|||...|||.:|||.|  :::::..|......     ||.||
Human   491 GLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFG--ISLSYLTGAAIWAD-----PGKYA 548

  Fly   580 VVGAAA-FSGSVTHTVSVAVIIFEMTGQITHVVPVMIAVLVANAVAALLQPSIYDSIILIKKLPY 643
            ::|||| ..|.|..|:|:.||:.|.|..:|:..|:|:.::.|..|..:....:||..|.::.:|:
Human   549 LMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPF 613

  Fly   644 LPDLLPSSSGMYSIFVEDFMVRDVKYIWH----GISYQKLKEVLKLNKTLRSLPLVDSPDN---M 701
            |....|.:|  :|:...:.|...|..:..    |:....|.:....:   ...|:|:..|:   .
Human   614 LHWEAPVTS--HSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNH---NGFPVVEHADDTQPA 673

  Fly   702 ILLGSVQRYELIKMIEKHIGREKRMEVAQKWQKEAQERALEEEKKKQEVELKMRRPSRFEVLPA- 765
            .|.|.:.|.:||.:: ||                   :...|......|:.::|.....:..|. 
Human   674 RLQGLILRSQLIVLL-KH-------------------KVFVERSNLGLVQRRLRLKDFRDAYPRF 718

  Fly   766 PDILSLRQIANDEMLPPKKRAETMHGSLAPRKSILKKTNSFNLKTYAQPMGHSPSITPYTTITGN 830
            |.|.|: .::.||      |..||                 :|..:..|       :|||.....
Human   719 PPIQSI-HVSQDE------RECTM-----------------DLSEFMNP-------SPYTVPQEA 752

  Fly   831 SEFRIRSAFEAI 842
            |..|:...|.|:
Human   753 SLPRVFKLFRAL 764

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ClC-aNP_788639.1 ClC_1_like 171..646 CDD:239655 150/532 (28%)
CBS_pair_SF 659..>718 CDD:449531 12/65 (18%)
CBS repeat 664..715 CDD:341358 11/57 (19%)
CBS_pair_SF <1032..1096 CDD:449531
CBS repeat 1053..1095 CDD:341358
CLCN7NP_001278.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..49
ClC_6_like 95..620 CDD:239657 158/574 (28%)
Selectivity filter part_1. /evidence=ECO:0000250 203..207 3/3 (100%)
Selectivity filter part_2. /evidence=ECO:0000250 245..249 3/3 (100%)
Selectivity filter part_3. /evidence=ECO:0000250 512..516 2/3 (67%)
CBS_pair_voltage-gated_CLC_euk_bac 626..790 CDD:341367 35/193 (18%)
CBS repeat 632..740 CDD:341367 26/154 (17%)
CBS repeat 746..789 CDD:341367 6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

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