Protein Alignment ClC-a and CLCN6

DIOPT Version :10

• Sequence 1: NP_788639.1
• Gene: ClC-a / 41428
• FlyBaseID: FBgn0051116
• Length: 1193
• Species: Drosophila melanogaster
• Sequence 2: NP_001277.2
• Gene: CLCN6 / 1185
• HGNCID: 2024
• Length: 869
• Species: Homo sapiens
• Alignment Length: 1076
• Identity: 221/1076 - (20%)
• Similarity: 390/1076 - (36%)
• Gaps: 350/1076 - (32%)

  Fly   117 GEFAKDEARKLKILEKRRKQEDK---QRNKELL------------------GKHSTRAKRVSSWI 160
            ||.......:|.||.:.:::||:   :::.|.|                  .|...|.:.|.
Human    19 GERETRTPEELTILGETQEEEDEILPRKDYESLDYDRCINDPYLEVLETMDNKKGRRYEAVK--- 80

  Fly   161 WRHTVARLGEDWVFLALLGIIMALLSFIMDKGISICTNARIWLYRDLTSQPFVQYIAWVSLPVCL 225
                       |:.:..:|:...|:...:|..:.:.|..:..:.:....:        .|...||
Human    81 -----------WMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVVQTSVEE--------CSQKGCL 126

  Fly   226 IL-------------FSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATL 277
            .|             |.|..:.||.|.:.||||||:|..|.||::...:..:||:.||:|:..::
Human   127 ALSLLELLGFNLTFVFLASLLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSV 191

  Fly   278 GSGMPLGKEGPFVHIASIVAQLLSKLVTSFQGI-----------YENESRNSEMLAAACAVGVGA 331
            ..|:.:.||||.:|..|:|...|.:    ||.|           :.::....:.::|..|.||.|
Human   192 AGGLFVEKEGPMIHSGSVVGAGLPQ----FQSISLRKIQFNFPYFRSDRDKRDFVSAGAAAGVAA 252

  Fly   332 CFAAPVGGVLFSIEVTTTYFAVRNYWRGFFAAVCGATVFRLL--AVWFQNADTVRALFLTNFTTE 394
            .|.||:||.|||:|..::::.....|:..|.::.........  .:.|.:..:.:...|.|| .|
Human   253 AFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFGSWGSFQLPGLLNF-GE 316

  Fly   395 FP----------FDPQELFVFALIGLVCGLGGASYVWVHRRYVLFMRSNKRMNKFLQKNRFLYPG 449
            |.          :...:|..|.::|::.||.||:          |...|||:.|:..:|....|.
Human   317 FKCSDSDKKCHLWTAMDLGFFVVMGVIGGLLGAT----------FNCLNKRLAKYRMRNVHPKPK 371

  Fly   450 FL----ALLVS--------------------SISFPLGTGQFLAGELSTHEQVTQLFSNFTWSRD 490
            .:    :||||                    |.|..:|...|   :|...|.|......|....|
Human   372 LVRVLESLLVSLVTTVVVFVASMVLGECRQMSSSSQIGNDSF---QLQVTEDVNSSIKTFFCPND 433

  Fly   491 ---DLTV-----EQAAVVT--HWMTSYTSVFGNLVIYTLFTFVVSIIASTIPVPSGMFIPVFKIG 545
               |:..     :::|::.  |...:::.|  .|.::.:..|:::.....|.||||:|:|....|
Human   434 TYNDMATLFFNPQESAILQLFHQDGTFSPV--TLALFFVLYFLLACWTYGISVPSGLFVPSLLCG 496

  Fly   546 AGFGRLVGEFMAVTFPHGVRYGGRLSPIMPGGYAVVGAAAFSGSVTH-TVSVAVIIFEMTGQITH 609
            |.|||||...:.       .|.| |..|..|.:|::|||||.|.|.. |:|:.||:.|.|.:||:
Human   497 AAFGRLVANVLK-------SYIG-LGHIYSGTFALIGAAAFLGGVVRMTISLTVILIESTNEITY 553

  Fly   610 VVPVMIAVLVANAVAALLQPSIYDSIILIKKLPYLPDLLPSSSGMYSIFVEDFMVRDVKYIWHGI 674
            .:|:|:.::||..........|||..:.::.:|.|.  ..:...|..:...|.|..::.|::...
Human   554 GLPIMVTLMVAKWTGDFFNKGIYDIHVGLRGVPLLE--WETEVEMDKLRASDIMEPNLTYVYPHT 616

  Fly   675 SYQKLKEVLKLNKTLRSLPLVDSPDNMILLGSVQRYELIKMIEKHIGREKR-MEVAQ------KW 732
            ..|.|..:|:...                      :....::.::.|.||. |:..|      |:
Human   617 RIQSLVSILRTTV----------------------HHAFPVVTENRGNEKEFMKGNQLISNNIKF 659

  Fly   733 QKEA-QERALEEEKKKQEVELKMRRPSRFEVLPAPDILSL--RQIANDEMLPPKKRAETMHGSLA 794
            :|.: ..||.|:.|:.|.:          :..|:.::.::  ..||::|   |.::.:.:...|.
Human   660 KKSSILTRAGEQRKRSQSM----------KSYPSSELRNMCDEHIASEE---PAEKEDLLQQMLE 711

  Fly   795 PRKSILKKTNSFNLKTYAQPMGHSPSITPYTTITGNSEFRIRSAFEAIFKKSTTLQDVQPDPETG 859
            .|                        .|||                         .::.||.
Human   712 RR------------------------YTPY-------------------------PNLYPDQ--- 724

  Fly   860 SLSPAASNHEVEVPRTPSTPGVSKKVQLPAQSNWDFVTDQIMLQVNPISTESNKMPAEKDFTDKA 924
              ||:......|..|..:..|:..:.||            :.|.|..:....::
Human   725 --SPSEDWTMEERFRPLTFHGLILRSQL------------VTLLVRGVCYSESQ----------- 764

  Fly   925 LSNNGDSSKQSPSIKFKANKVADVNRSPQTAKRCSKIRFANEVGVNGSPTRTKCKIKPENVLGYS 989
                  ||...|.:.: |....|..|.|                                    .
Human   765 ------SSASQPRLSY-AEMAEDYPRYP------------------------------------D 786

  Fly   990 IEDVDET-TNPESLAESIQKPKSVRLPRERVIDMSPEDQKQWELEEMLKPIDLQKANVHIDPSPF 1053
            |.|:|.| .||                 ..::|::|                      :::||||
Human   787 IHDLDLTLLNP-----------------RMIVDVTP----------------------YMNPSPF 812

  Fly  1054 QLVERTSILKVHSLFSMVGINH-AYVTKIGRLVGVV 1088
            .:...|.:.:|.:||..:|:.| ..|..:|.:||::
Human   813 TVSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGII 848

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	140/545 (26%)
		CBS_pair_SF	659..>718	CDD:449531	6/58 (10%)
		CBS repeat	664..715	CDD:341358	4/50 (8%)
		CBS_pair_SF	<1032..1096	CDD:449531	14/58 (24%)
		CBS repeat	1053..1095	CDD:341358	11/37 (30%)
CLCN6	NP_001277.2	ClC_6_like	49..588	CDD:239657	144/588 (24%)
		Selectivity filter part_1. /evidence=ECO:0000250	156..160		3/3 (100%)
		Selectivity filter part_2. /evidence=ECO:0000250	198..202		2/3 (67%)
		Selectivity filter part_3. /evidence=ECO:0000250	487..491		2/3 (67%)
		CBS_pair_voltage-gated_CLC_euk_bac	600..856	CDD:341367	68/443 (15%)
		CBS repeat	606..806	CDD:341367	52/393 (13%)
		CBS repeat	812..855	CDD:341367	11/37 (30%)