Protein Alignment ClC-a and CLCN5

DIOPT Version :10

• Sequence 1: NP_788639.1
• Gene: ClC-a / 41428
• FlyBaseID: FBgn0051116
• Length: 1193
• Species: Drosophila melanogaster
• Sequence 2: NP_001427685.1
• Gene: CLCN5 / 1184
• HGNCID: 2023
• Length: 820
• Species: Homo sapiens
• Alignment Length: 687
• Identity: 207/687 - (30%)
• Similarity: 314/687 - (45%)
• Gaps: 153/687 - (22%)

  Fly   133 RRKQEDKQRNKELLGKHSTRAKRVSSWIWRHTVARLGEDWVFLALLGIIMALLSFIMD------- 190
            |.|..|:.|::|:     |...:.|:|...|:|:.....|:.:.|:|::...|:.::|
Human    98 REKSRDRDRHREI-----TNKSKESTWALIHSVSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMT 157

  Fly   191 ---KGI----------SICTNARIWLYRDLTSQP----------------------FVQYIAWVS 220
               :||          ..|.|:....:.:....|                      :..|:.|..
Human   158 DLKEGICTGGFWFNHEHCCWNSEHVTFEERDKCPEWNSWSQLIISTDEGAFAYIVNYFMYVLWAL 222

  Fly   221 LPVCLILFSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLGK 285
            |   ....:...|.:.||.:.||||||:||||.|..::.||...|||.|.|.|...:.||:.|||
Human   223 L---FAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGK 284

  Fly   286 EGPFVHIASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTTTY 350
            |||.||:|.....:|......::   :||::..|:|:||.|.||...|.||:||||||:|..:.|
Human   285 EGPLVHVACCCGNILCHCFNKYR---KNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYY 346

  Fly   351 FAVRNYWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLVCGLG 415
            |.::..||.||||:..|...|.:.. |.|:..|  ||...|.|  |:...||..|.|:|:..||.
Human   347 FPLKTLWRSFFAALVAAFTLRSINP-FGNSRLV--LFYVEFHT--PWHLFELVPFILLGIFGGLW 406

  Fly   416 GASYVWVHRRYVLFMRSN-----KRMNKFLQKNRFLYPGFLALLVSSI----SFPLGTGQFLAGE 471
            ||          ||:|:|     ||....|.|    ||....|:|::|    :||   .::.  .
Human   407 GA----------LFIRTNIAWCRKRKTTQLGK----YPVIEVLVVTAITAILAFP---NEYT--R 452

  Fly   472 LSTHEQVTQLFSN---------------FTWSR-DDLTVEQAAVVTH---WMTSYTSVFGNLVIY 517
            :||.|.:::||::               |..|: .:|....|.|..:   |..:.|.:.  .::.
Human   453 MSTSELISELFNDCGLLDSSKLCDYENRFNTSKGGELPDRPAGVGVYSAMWQLALTLIL--KIVI 515

  Fly   518 TLFTFVVSIIASTIPVPSGMFIPVFKIGAGFGRLVG---EFMAVTFPHGVRYGGRLSP----IMP 575
            |:|||.:.|       |||:|||...:||..|||:|   |.:|........:....|.    |.|
Human   516 TIFTFGMKI-------PSGLFIPSMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITP 573

  Fly   576 GGYAVVGAAAFSGSVTH-TVSVAVIIFEMTGQITHVVPVMIAVLVANAVA-ALLQPSIYDSIILI 638
            |.||:|||||..|.||. |||:.||:||:||.:.::||:|.|.:.:..|| ||.:..|||:.|.:
Human   574 GLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRL 638

  Fly   639 KKLPYLP------------DLLP--SSSGMYSIFVEDFM-VRDVKYIWHGISYQKLKEVLKLNKT 688
            ...|:|.            |::.  .:..:.::..:|.| |.||             |.:....|
Human   639 NGYPFLEAKEEFAHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDV-------------ETIISETT 690

  Fly   689 LRSLPLVDSPDNMILLGSVQRYELIKMIEKHIGREKR 725
            ....|:|.|.::..|:|.|.|.:||..||.  .|:|:
Human   691 YSGFPVVVSRESQRLVGFVLRRDLIISIEN--ARKKQ 725

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	176/565 (31%)
		CBS_pair_SF	659..>718	CDD:449531	17/59 (29%)
		CBS repeat	664..715	CDD:341358	14/50 (28%)
		CBS_pair_SF	<1032..1096	CDD:449531
		CBS repeat	1053..1095	CDD:341358
CLCN5	NP_001427685.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26
		Selectivity filter part_1. /evidence=ECO:0000250	241..245		3/3 (100%)
		Selectivity filter part_2. /evidence=ECO:0000250	283..287		3/3 (100%)
		Selectivity filter part_3. /evidence=ECO:0000250	527..531		2/3 (67%)