DRSC/TRiP Functional Genomics Resources

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Protein Alignment ClC-a and CLCN4

DIOPT Version :10

Sequence 1:NP_788639.1 Gene:ClC-a / 41428 FlyBaseID:FBgn0051116 Length:1193 Species:Drosophila melanogaster
Sequence 2:NP_001821.2 Gene:CLCN4 / 1183 HGNCID:2022 Length:760 Species:Homo sapiens


Alignment Length:742 Identity:215/742 - (28%)
Similarity:324/742 - (43%) Gaps:178/742 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   133 RRKQEDKQRNKELLGKHSTRAKRVSSWIWRHTVARLGEDWVFLALLGIIMALLSFIMDKGI---- 193
            |.|..|..|::::..|     .:.|.|.:..::......||.:.|:|::...|:.::|..:    
Human    37 REKSRDTDRHRKITSK-----SKESIWEFIKSLLDAWSGWVVMLLIGLLAGTLAGVIDLAVDWMT 96

  Fly   194 ----SICTNARIW-------------LYRDLTSQP----------------------FVQYIAWV 219
                .:|.:| .|             .:.|....|                      ::.||.|.
Human    97 DLKEGVCLSA-FWYSHEQCCWTSNETTFEDRDKCPLWQKWSELLVNQSEGASAYILNYLMYILWA 160

  Fly   220 SLPVCLILFSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLG 284
            .|   ....:...|.:.||.:.||||||:||||.|..::.||...||:.|.:.|...:.||:.||
Human   161 LL---FAFLAVSLVRVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLG 222

  Fly   285 KEGPFVHIASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTTT 349
            ||||.||:|.......|.|.:.:.   :||.:..|:|:||.|.||...|.||:||||||:|..:.
Human   223 KEGPLVHVACCCGNFFSSLFSKYS---KNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSY 284

  Fly   350 YFAVRNYWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLVCGL 414
            ||.::..||.||||:..|...|.:.. |.|:..|  ||...:.|  |:...|||.|.|:|:..||
Human   285 YFPLKTLWRSFFAALVAAFTLRSINP-FGNSRLV--LFYVEYHT--PWYMAELFPFILLGVFGGL 344

  Fly   415 GGASYV-----WVHRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSSISFPLG-----TGQFLA 469
            .|..::     |..|      |...|:.|        ||....::|::|:..:.     |.|   
Human   345 WGTLFIRCNIAWCRR------RKTTRLGK--------YPVLEVIVVTAITAIIAYPNPYTRQ--- 392

  Fly   470 GELSTHEQVTQLFS-----------------NFTWSRDDLTVEQAAVVTHWMTSYTSVFGNLVIY 517
               ||.|.:::||:                 |.|...||:....|.|..     ||::: .|.:.
Human   393 ---STSELISELFNDCGALESSQLCDYINDPNMTRPVDDIPDRPAGVGV-----YTAMW-QLALA 448

  Fly   518 TLFTFVVSIIASTIPVPSGMFIPVFKIGAGFGRLVG---EFMA------VTFPHGVRYGGRLSPI 573
            .:|..||:|....:.:|||:|||...:||..||:||   |.:|      :.|.:..|.|.  ..:
Human   449 LIFKIVVTIFTFGMKIPSGLFIPSMAVGAIAGRMVGIGVEQLAYHHHDWIIFRNWCRPGA--DCV 511

  Fly   574 MPGGYAVVGAAAFSGSVTH-TVSVAVIIFEMTGQITHVVPVMIAVLVANAVA-ALLQPSIYDSII 636
            .||.||:|||||..|.||. |||:.||:||:||.:.::||:|.|.:.:..|| |..:..||::.|
Human   512 TPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHI 576

  Fly   637 LIKKLPYL------------PDLLPSSSG--MYSIFVEDFM-VRDVKYIWHGISYQKLKEVLKLN 686
            .:...|:|            .|::....|  ..|:..:|.| |.||:.:        :||.    
Human   577 HLNGYPFLDVKDEFTHRTLATDVMRPRRGEPPLSVLTQDSMTVEDVETL--------IKET---- 629

  Fly   687 KTLRSLPLVDSPDNMILLGSVQRYELIKMIEKHIGREKRMEVAQKWQKEAQERALEEEKKKQEVE 751
             .....|:|.|.|:..|:|..||.|||..|                 |.|::|  :|......:.
Human   630 -DYNGFPVVVSRDSERLIGFAQRRELILAI-----------------KNARQR--QEGIVSNSIM 674

  Fly   752 LKMRRPSRFEVLPA--PDILSLRQIAN 776
            .....|..   |||  |..|.||:|.|
Human   675 YFTEEPPE---LPANSPHPLKLRRILN 698

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ClC-aNP_788639.1 ClC_1_like 171..646 CDD:239655 172/567 (30%)
CBS_pair_SF 659..>718 CDD:449531 19/59 (32%)
CBS repeat 664..715 CDD:341358 16/50 (32%)
CBS_pair_SF <1032..1096 CDD:449531
CBS repeat 1053..1095 CDD:341358
CLCN4NP_001821.2 Required for localization in the endoplasmic reticulum. /evidence=ECO:0000269|PubMed:17023393 14..63 7/30 (23%)
ClC_3_like 78..584 CDD:239656 168/545 (31%)
Selectivity filter part_1. /evidence=ECO:0000250 180..184 3/3 (100%)
Selectivity filter part_2. /evidence=ECO:0000250 222..226 3/3 (100%)
Selectivity filter part_3. /evidence=ECO:0000250 467..471 2/3 (67%)
CBS_pair_voltage-gated_CLC_euk_bac 595..745 CDD:341367 36/139 (26%)
CBS repeat 601..696 CDD:341367 33/129 (26%)
Required for localization in the endoplasmic reticulum. /evidence=ECO:0000269|PubMed:28972156 667..696 8/31 (26%)
CBS repeat 702..744 CDD:341367
Blue background indicates that the domain is not in the aligned region.

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