back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-a and CLCN3

DIOPT Version :10

Sequence 1:	NP_788639.1	Gene:	ClC-a / 41428	FlyBaseID:	FBgn0051116	Length:	1193	Species:	Drosophila melanogaster
Sequence 2:	NP_776297.2	Gene:	CLCN3 / 1182	HGNCID:	2021	Length:	866	Species:	Homo sapiens

Alignment Length:	930	Identity:	247/930 - (26%)
Similarity:	371/930 - (39%)	Gaps:	271/930 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 DSDSSDDDDPIGYIDTLMYGRYTKDLGEFAKDEARKLKILEK-----------------RRKQED 138
            |..:|:||:.:.. ||.:...||...|.........|.:|::                 |.|.:|
Human    37 DFQTSEDDNLLDG-DTAVGTHYTMTNGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKD 100

  Fly   139 KQRNKELLGKHSTRAKRVSSWIWRHTVARLGEDWVFLALLGIIMALLSFIMDKGI--------SI 195
            ::|::.:..|     |:.|:|....::......|:.:.|.|:....|:.::|...        .|
Human   101 RERHRRINSK-----KKESAWEMTKSLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGI 160

  Fly   196 CTNARIWL---------------YRDLTSQ--------------------PFVQYIAWVSLPVCL 225
            |.:| :|.               .||...|                    .::.||.|.   :..
Human   161 CLSA-LWYNHEQCCWGSNETTFEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWA---LSF 221

  Fly   226 ILFSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLGKEGPFV 290
            ...:...|.:.||.:.||||||:||||.|..::.||...||:.|.|.|...:.||:.||||||.|
Human   222 AFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLV 286

  Fly   291 HIASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTTTYFAVRN 355
            |:|.....:.|.|...:.   .||::..|:|:||.|.||...|.||:||||||:|..:.||.::.
Human   287 HVACCCGNIFSYLFPKYS---TNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKT 348

  Fly   356 YWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLVCGLGGASYV 420
            .||.||||:..|.|.|.:.. |.|:..|  ||...:.|  |:...|||.|.|:|:..||.||.::
Human   349 LWRSFFAALVAAFVLRSINP-FGNSRLV--LFYVEYHT--PWYLFELFPFILLGVFGGLWGAFFI 408

  Fly   421 -----WVHRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSS----ISFPLGTGQFLAGELSTHE 476
                 |..||         :..||.:     ||....::|::    |:||....:     |:|.|
Human   409 RANIAWCRRR---------KSTKFGK-----YPVLEVIIVAAITAVIAFPNPYTR-----LNTSE 454

  Fly   477 QVTQLFS-----------------NFTWSRDDLTVEQAAVVTH---WMTSYTSVFGNLVIYTLFT 521
            .:.:||:                 |.:...||:....|.:..:   |......:|  .:|.|:||
Human   455 LIKELFTDCGPLESSSLCDYRNDMNASKIVDDIPDRPAGIGVYSAIWQLCLALIF--KIIMTVFT 517

  Fly   522 FVVSIIASTIPVPSGMFIPVFKIGAGFGRLVG---EFMA------VTFPHGVRYGGRLSPIMPGG 577
            |       .|.||||:|||...|||..||:||   |.:|      ..|......|.  ..|.||.
Human   518 F-------GIKVPSGLFIPSMAIGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVGA--DCITPGL 573

  Fly   578 YAVVGAAAFSGSVTH-TVSVAVIIFEMTGQITHVVPVMIAVLVANAVA-ALLQPSIYDSIILIKK 640
            ||:|||||..|.||. |||:.||:||:||.:.::||:|.||:.:..|. |..:..||::.|.:..
Human   574 YAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNG 638

  Fly   641 LPYL----------------------PDLLPSSSGMYSIFVEDFM-VRDVKYIWHGISYQKLKEV 682
            .|:|                      |.|        ::..:|.| |.|::.:.:..||
Human   639 YPFLDAKEEFTHTTLAADVMRPRRNDPPL--------AVLTQDNMTVDDIENMINETSY------ 689

  Fly   683 LKLNKTLRSLPLVDSPDNMILLGSVQRYELIKMIEKHIGREKRMEVAQKWQKEAQERALEEEKKK 747
                   ...|::.|.::..|:|...|.:|                         ..|:|..:||
Human   690 -------NGFPVIMSKESQRLVGFALRRDL-------------------------TIAIESARKK 722

  Fly   748 QE-------VELKMRRPSRFEVLPA--PDILSLRQIANDEMLP-------PKKRAETMHGSLAPR 796
            ||       |......||    |||  |..|.||.|.  :|.|       |.:....:...|..|
Human   723 QEGIVGSSRVCFAQHTPS----LPAESPRPLKLRSIL--DMSPFTVTDHTPMEIVVDIFRKLGLR 781

  Fly   797 K----------SILKKTNSF----NLKTYAQPMG---------HSPSITP-------YTTITGN- 830
            :          .|:.|.|..    .||.:.:|:.         :.|:..|       :..:..|
Human   782 QCLVTHNGIVLGIITKKNILEHLEQLKQHVEPLAPPWHYNKKRYPPAYGPDGKPRPRFNNVQLNL 846

  Fly   831 -SEFRIRSAFEAIFKKSTTL 849
             .|.|..:..|.....||||
Human   847 TDEEREETEEEVYLLNSTTL 866

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.