DRSC/TRiP Functional Genomics Resources

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Protein Alignment ClC-a and CLCN2

DIOPT Version :10

Sequence 1:NP_788639.1 Gene:ClC-a / 41428 FlyBaseID:FBgn0051116 Length:1193 Species:Drosophila melanogaster
Sequence 2:NP_004357.3 Gene:CLCN2 / 1181 HGNCID:2020 Length:898 Species:Homo sapiens


Alignment Length:1093 Identity:453/1093 - (41%)
Similarity:607/1093 - (55%) Gaps:224/1093 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   103 YIDTLMYGRYTKDLGEFAKDEARKLKI--LEKRRKQEDKQRNKELLGKHSTRAKR---VSSWIWR 162
            |..||||||||:|||.|||:||.::::  .|..:.....:...|||....:|..|   .|....:
Human    17 YEQTLMYGRYTQDLGAFAKEEAARIRLGGPEPWKGPPSSRAAPELLEYGRSRCARCRVCSVRCHK 81

  Fly   163 HTVARLGEDWVFLALLGIIMALLSFIMDKGISICTNARIWLYRDLTSQPFVQYIAWVSLPVCLIL 227
            ..|:|:||||:||.|||::|||:|::||..|:.|..|:.|:.|.|.:...:||:|||:.||.||.
Human    82 FLVSRVGEDWIFLVLLGLLMALVSWVMDYAIAACLQAQQWMSRGLNTSILLQYLAWVTYPVVLIT 146

  Fly   228 FSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLGKEGPFVHI 292
            |||||..::|||::||||||||||||||.||||||.||.:|||||||..||||||||||||||||
Human   147 FSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFIAKVIGLTCALGSGMPLGKEGPFVHI 211

  Fly   293 ASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTTTYFAVRNYW 357
            ||:.|.||||.::.|.|||||||||:||||||||||||.|||||:||||||||||:|:|||||||
Human   212 ASMCAALLSKFLSLFGGIYENESRNTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYW 276

  Fly   358 RGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLVCGLGGASYVWV 422
            ||||||...|.:||:||||.::.:|:.|||.|.|..:||||.|||..||:||:..|.|||.:|::
Human   277 RGFFAATFSAFIFRVLAVWNRDEETITALFKTRFRLDFPFDLQELPAFAVIGIASGFGGALFVYL 341

  Fly   423 HRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSSISFPLGTGQFLAGELSTHEQVTQLFSNFTW 487
            :|:.|..||..|.:|:||.:.|.|:|..:.||:|:::||.|.|||:||:||..|.:..||.|.||
Human   342 NRKIVQVMRKQKTINRFLMRKRLLFPALVTLLISTLTFPPGFGQFMAGQLSQKETLVTLFDNRTW 406

  Fly   488 SRDDLT--VEQAAVVTHWMTSYTSVFGNLVIYTLFTFVVSIIASTIPVPSGMFIPVFKIGAGFGR 550
            .|..|.  :|..:....|.....:||..|||:.|..|.:|.:|:|||||.|.|:|||.|||.|||
Human   407 VRQGLVEELEPPSTSQAWNPPRANVFLTLVIFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGR 471

  Fly   551 LVGEFMAVTFPHGVRYGGRLSPIMPGGYAVVGAAAFSGSVTHTVSVAVIIFEMTGQITHVVPVMI 615
            ||||.||..||.|:........|:|||||||||||.:|:||||||.|||:||:||||.|::||||
Human   472 LVGESMAAWFPDGIHTDSSTYRIVPGGYAVVGAAALAGAVTHTVSTAVIVFELTGQIAHILPVMI 536

  Fly   616 AVLVANAVAALLQPSIYDSIILIKKLPYLPDLLPSSSGMYSIFVEDFMVRDVKYIWHGISYQKLK 680
            ||::|||||..||||:|||||.||||||||:|.......|.:.|||.|||||.::....:::.|:
Human   537 AVILANAVAQSLQPSLYDSIIRIKKLPYLPELGWGRHQQYRVRVEDIMVRDVPHVALSCTFRDLR 601

  Fly   681 EVLKLNKTL-RSLPLVDSPDNMILLGSVQRYELIKMIEKHIGREKRMEVAQKWQKEAQERALEEE 744
              |.|::|. |.|.||:||::||||||::|.:::.::...:...:|.:..|: ::..|...|.::
Human   602 --LALHRTKGRMLALVESPESMILLGSIERSQVVALLGAQLSPARRRQHMQE-RRATQTSPLSDQ 663

  Fly   745 KKKQEVELKMRRPSRFEVLPAPDILSLRQIANDEMLPPKKRAETMHGSLAPRKSILKKTNSFNLK 809
                            |..|.|:.....|:..::...|..|.|| |   .|.|..||:..|    
Human   664 ----------------EGPPTPEASVCFQVNTEDSAFPAARGET-H---KPLKPALKRGPS---- 704

  Fly   810 TYAQPMGHSPSITPYTTITGNSE---FRIRSAFEAIFKKSTTLQDVQPDPETGSLSPAASNHEVE 871
             ..:.:|.||        ||::|   ..:||.|                  .||..|.|::.::|
Human   705 -VTRNLGESP--------TGSAESAGIALRSLF------------------CGSPPPEAASEKLE 742

  Fly   872 VPRTPSTPGVSKKVQLPAQSNWDFVTDQIMLQVNPISTESNKMPAEKDFTDKALSNNGDSSKQSP 936
                                                |.|..|:                      
Human   743 ------------------------------------SCEKRKL---------------------- 749

  Fly   937 SIKFKANKVADVNRSPQTAKRCSKIRFANEVGVNGSPTRTKCKIKPENVLGYSIEDVDETTNPES 1001
                               ||. :|..|::..:.|                              
Human   750 -------------------KRV-RISLASDADLEG------------------------------ 764

  Fly  1002 LAESIQKPKSVRLPRERVIDMSPEDQKQWELEEMLKPIDLQKANVHIDPSPFQLVERTSILKVHS 1066
                               :||||:..:||.:::.:|::.  ::..|||:|||||||||:.|.|:
Human   765 -------------------EMSPEEILEWEEQQLDEPVNF--SDCKIDPAPFQLVERTSLHKTHT 808

  Fly  1067 LFSMVGINHAYVTKIGRLVGVVGLKELRKAIEDINSNSFVPPTRDEDADEKPAVEKPLLSTNSSD 1131
            :||::|::|||||.||||:|:|.|||||||||...:...|            .|..||.|..   
Human   809 IFSLLGVDHAYVTSIGRLIGIVTLKELRKAIEGSVTAQGV------------KVRPPLASFR--- 858

  Fly  1132 KAVDMTVTSMDSALSNSENCSDIEMEHIKHTDKGTVSLTMPPQESKQSPSADK 1184
                      |||.|:    ||.|...: |...|..|....|:|...|.|.||
Human   859 ----------DSATSS----SDTETTEV-HALWGPHSRHGLPREGSPSDSDDK 896

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
ClC-aNP_788639.1 ClC_1_like 171..646 CDD:239655 292/476 (61%)
CBS_pair_SF 659..>718 CDD:449531 25/59 (42%)
CBS repeat 664..715 CDD:341358 21/51 (41%)
CBS_pair_SF <1032..1096 CDD:449531 34/63 (54%)
CBS repeat 1053..1095 CDD:341358 28/41 (68%)
CLCN2NP_004357.3 Essential for channel gating by both voltage and cell volume. /evidence=ECO:0000250|UniProtKB:P35525, ECO:0000269|PubMed:38345841 16..34 12/16 (75%)
Modulates channel gating by both voltage and cell volume. /evidence=ECO:0000250|UniProtKB:P35525 36..49 3/12 (25%)
ClC_1_like 90..567 CDD:239655 292/476 (61%)
Selectivity filter part_1. /evidence=ECO:0000250 161..165 3/3 (100%)
Selectivity filter part_2. /evidence=ECO:0000250 203..207 3/3 (100%)
Selectivity filter part_3. /evidence=ECO:0000250 457..461 2/3 (67%)
CBS_pair_voltage-gated_CLC_euk_bac 579..838 CDD:341367 105/441 (24%)
CBS repeat 585..789 CDD:341367 68/386 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 643..672 7/45 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 686..717 14/47 (30%)
CBS repeat 795..837 CDD:341367 28/41 (68%)