Protein Alignment ClC-a and CLCN1

DIOPT Version :10

• Sequence 1: NP_788639.1
• Gene: ClC-a / 41428
• FlyBaseID: FBgn0051116
• Length: 1193
• Species: Drosophila melanogaster
• Sequence 2: NP_000074.3
• Gene: CLCN1 / 1180
• HGNCID: 2019
• Length: 988
• Species: Homo sapiens
• Alignment Length: 1149
• Identity: 424/1149 - (36%)
• Similarity: 602/1149 - (52%)
• Gaps: 241/1149 - (20%)

  Fly    63 EELRHVQR---------HPKIKSHAFYPCPP---PAENA-------RDSDSSDDDDPIGYIDTLM 108
            |:.|..||         .|:.:...|..|..   |:||.       :|:....:..|     |.:
Human     2 EQSRSQQRGGEQSWWGSDPQYQYMPFEHCTSYGLPSENGGLQHRLRKDAGPRHNVHP-----TQI 61

  Fly   109 YGRYTKDLGEFAKDEARKLKILEKR---RKQEDKQRNKELLGKHSTRAKRVSSWIWRHTVARLGE 170
            ||.:.:...:..:|.....|.....   .|.||          |.::.:.....:.:....:|||
Human    62 YGHHKEQFSDREQDIGMPKKTGSSSTVDSKDED----------HYSKCQDCIHRLGQVVRRKLGE 116

  Fly   171 DWVFLALLGIIMALLSFIMDKGISICTNARIWLYRDLTSQPFVQYIAWVSLPVCLILFSAGFVHL 235
            |.:||.|||::|||:|:.||...:....|..|.|..:.....:|::.||:.|:.||||||.|.||
Human   117 DGIFLVLLGLLMALVSWSMDYVSAKSLQAYKWSYAQMQPSLPLQFLVWVTFPLVLILFSALFCHL 181

  Fly   236 IAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLGKEGPFVHIASIVAQLL 300
            |:||::||||||||||||||.||||||.|..||||:.|||.||||:|:||||||||||||.|.:|
Human   182 ISPQAVGSGIPEMKTILRGVVLKEYLTMKAFVAKVVALTAGLGSGIPVGKEGPFVHIASICAAVL 246

  Fly   301 SKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTTTYFAVRNYWRGFFAAVC 365
            ||.::.|.|:||.....|::|...||||||.||..|:||||||||||:|||||||||||||||..
Human   247 SKFMSVFCGVYEQPYYYSDILTVGCAVGVGCCFGTPLGGVLFSIEVTSTYFAVRNYWRGFFAATF 311

  Fly   366 GATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLVCGLGGASYVWVHRRYVLFM 430
            .|.|||:||||.::|.|:.|||.|||..:||||.:||..||.||:.|||.||.:|::||:.:|.:
Human   312 SAFVFRVLAVWNKDAVTITALFRTNFRMDFPFDLKELPAFAAIGICCGLLGAVFVYLHRQVMLGV 376

  Fly   431 RSNKRMNKFLQKNRFLYPGFLALLVSSISFPLGTGQFLAGELSTHEQVTQLFSNFTWSR---DDL 492
            |.:|.:::||.|:|.||||.:..:::|.:||.|.|||:||||...|.::.||.|.||.:   |..
Human   377 RKHKALSQFLAKHRLLYPGIVTFVIASFTFPPGMGQFMAGELMPREAISTLFDNNTWVKHAGDPE 441

  Fly   493 TVEQAAVVTHWMTSYTSVFGNLVIYTLFTFVVSIIASTIPVPSGMFIPVFKIGAGFGRLVGEFMA 557
            ::.|:||   |:....:|...:.::.:..|.:||:|:|:|:|.|.|:|||.:||.|||||||.||
Human   442 SLGQSAV---WIHPRVNVVIIIFLFFVMKFWMSIVATTMPIPCGGFMPVFVLGAAFGRLVGEIMA 503

  Fly   558 VTFPHGVRYGGRLSPIMPGGYAVVGAAAFSGSVTHTVSVAVIIFEMTGQITHVVPVMIAVLVANA 622
            :.||.|:.:...:..|:||||||:||||.:|:|:||||.|||.||:||||.|::|:|:||::||.
Human   504 MLFPDGILFDDIIYKILPGGYAVIGAAALTGAVSHTVSTAVICFELTGQIAHILPMMVAVILANM 568

  Fly   623 VAALLQPSIYDSIILIKKLPYLPDLLPSSSGMYSIFVEDFMVRDVKYIWHGISYQKLKEVLKLNK 687
            ||..||||:|||||.:|||||||||..:....|:|||||.||||||::....:|.:|:.:|: ..
Human   569 VAQSLQPSLYDSIIQVKKLPYLPDLGWNQLSKYTIFVEDIMVRDVKFVSASYTYGELRTLLQ-TT 632

  Fly   688 TLRSLPLVDSPDNMILLGSVQRYELIKMIEKHIGREKRMEVAQKWQKEAQERALEEEKKKQEVEL 752
            |:::||||||.|:|||||||:|.||..::::|:..|:|:..||:..::..|...:.:.:.....|
Human   633 TVKTLPLVDSKDSMILLGSVERSELQALLQRHLCPERRLRAAQEMARKLSELPYDGKARLAGEGL 697

  Fly   753 KMRRPSRFEVLPAPDILSLRQIANDEMLPPKKRAETMHGSLAPRKSILKKTNSFNLKTYAQPMGH 817
            ....|.|.|.....|......::....|||         |||
Human   698 PGAPPGRPESFAFVDEDEDEDLSGKSELPP---------SLA----------------------- 730

  Fly   818 SPSITPYTTITGNSEFRIRSAFEAIFKKSTTLQDVQPDPETGSLSPAASNHEVEVPRTPSTPGVS 882
               :.|.|                                |..|||       |.|..| .||..
Human   731 ---LHPST--------------------------------TAPLSP-------EEPNGP-LPGHK 752

  Fly   883 KKVQLPAQSNWDFVTDQIMLQVNPISTESNKMPAEKDFTDKALSNNGDSSKQSPSIKFKANKVAD 947
            ::.:.|                                         :.:.|.|||.
Human   753 QQPEAP-----------------------------------------EPAGQRPSIF-------- 768

  Fly   948 VNRSPQTAKRCSKIRFANEVGVNGSPTRTKCKIKPENVLGYSIEDVDETTNPESLAESIQKPKSV 1012
                 |:...|...|        ..||:.|                  ||...:
Human   769 -----QSLLHCLLGR--------ARPTKKK------------------TTQDST----------- 791

  Fly  1013 RLPRERVIDMSPEDQKQWELEEMLKPIDLQKANVHIDPSPFQLVERTSILKVHSLFSMVGINHAY 1077
                :.|.:||||:.:.||.|::.:|:...  :..||.|||||||:|::.|.|:|||::|::.||
Human   792 ----DLVDNMSPEEIEAWEQEQLSQPVCFD--SCCIDQSPFQLVEQTTLHKTHTLFSLLGLHLAY 850

  Fly  1078 VTKIGRLVGVVGLKELRKAIEDINSNSFVPPTRDEDADEKPAVEKPLLS---TNSSDKAVDMTVT 1139
            ||.:|:|.||:.|:||:||||. ::.|.|            .:..||.|   |.|:.|
Human   851 VTSMGKLRGVLALEELQKAIEG-HTKSGV------------QLRPPLASFRNTTSTRK------- 895

  Fly  1140 SMDSALSNSENCSDIEMEHIKHTDKGTVSLTMPPQESKQSPSAD 1183
            |..:..|::||. ::..:....|..|.| :...|:....|||.:
Human   896 STGAPPSSAENW-NLPEDRPGATGTGDV-IAASPETPVPSPSPE 937

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	264/477 (55%)
		CBS_pair_SF	659..>718	CDD:449531	30/58 (52%)
		CBS repeat	664..715	CDD:341358	26/50 (52%)
		CBS_pair_SF	<1032..1096	CDD:449531	29/63 (46%)
		CBS repeat	1053..1095	CDD:341358	23/41 (56%)
CLCN1	NP_000074.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	65..92		2/26 (8%)
		ClC_1_like	131..592	CDD:239655	255/463 (55%)
		Selectivity filter part_1. /evidence=ECO:0000250	188..192		3/3 (100%)
		Selectivity filter part_2. /evidence=ECO:0000250	230..234		3/3 (100%)
		Selectivity filter part_3. /evidence=ECO:0000250	482..486		2/3 (67%)
		CBS_pair_SF	605..869	CDD:449531	107/436 (25%)
		CBS repeat	610..820	CDD:341367	76/382 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	713..764		18/166 (11%)
		CBS repeat	826..868	CDD:341367	23/41 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	880..988		17/67 (25%)