Protein Alignment ClC-a and clcn1

DIOPT Version :10

• Sequence 1: NP_788639.1
• Gene: ClC-a / 41428
• FlyBaseID: FBgn0051116
• Length: 1193
• Species: Drosophila melanogaster
• Sequence 2: XP_031761520.1
• Gene: clcn1 / 101731973
• XenbaseID: XB-GENE-6085854
• Length: 942
• Species: Xenopus tropicalis
• Alignment Length: 1189
• Identity: 432/1189 - (36%)
• Similarity: 613/1189 - (51%)
• Gaps: 306/1189 - (25%)

  Fly    23 IIHDEEFGEENVELVDSEWADFEKF-ICQLRKRRNSAMSMEEELRHVQRHPKIKSHAFYPCPPPA 86
            ::.|.:..|.| |.....|.|..:: ..|||...:..:..|..                  |||.
 Frog     9 LMEDPKANEGN-ERKSGWWGDDPQYQYMQLRDCSSYGIPSETS------------------PPPL 54

  Fly    87 ENARDSDSSDDDDPIGYIDTLMYGRYTKDLGEFAKDEARKLKILEKRRKQEDKQRN--KELLGKH 149
            :...      ::.|.....|  ||.||::|.:||:.||.|| :.||:|.:..|..:  ||...|.
 Frog    55 QETL------EEQPPSQKQT--YGHYTEELSQFARKEAVKL-LQEKQRAEPTKPPDVQKECYSKC 110

  Fly   150 STRAKRVSSWIWRHTVARLGEDWVFLALLGIIMALLSFIMDKGISICTNARIWLYRDLTSQPFVQ 214
            ....:|:..:|    :.:|.|||:||.|||.:||::|:.||...|....|..|:|..|:...::|
 Frog   111 HRCIQRLKQYI----IKKLAEDWIFLVLLGFVMAIVSWSMDYASSKSLLAYRWMYESLSPNVWIQ 171

  Fly   215 YIAWVSLPVCLILFSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGS 279
            |:||||.|:.||||:|.|.|:::||:|||||||:|.|||||.||||||.|..|||||||||:|||
 Frog   172 YLAWVSYPLILILFAAVFCHVVSPQAIGSGIPELKVILRGVVLKEYLTLKAFVAKVIGLTASLGS 236

  Fly   280 GMPLGKEGPFVHIASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSI 344
            ||||||||||||||||.:.:|||.::.|.|:|:.....:::|...||||||.||..|:|||||||
 Frog   237 GMPLGKEGPFVHIASICSVVLSKFMSVFCGVYQQAYYYTDVLTVGCAVGVGCCFGTPLGGVLFSI 301

  Fly   345 EVTTTYFAVRNYWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIG 409
            |||::||||||||||||||...|.:||:.|||.::|.|:.|||.|||..|||||.|||..||:||
 Frog   302 EVTSSYFAVRNYWRGFFAATFSAFMFRVFAVWNKDAVTITALFRTNFRMEFPFDLQELPAFAVIG 366

  Fly   410 LVCGLGGASYVWVHRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSSISFPLGTGQFLAGELST 474
            :..|..||.:|:::|:.|..:|||:.::.||.:.||:||..:...:::::||.|.||::||.|..
 Frog   367 ICSGFLGAFFVFMNRQVVEGIRSNQTLSSFLSRYRFIYPAAVTFCIATLTFPPGFGQYMAGALMP 431

  Fly   475 HEQVTQLFSNFTWSR---DDLTVEQAAVVTHWMTSYTSVFGNLVIYTLFTFVVSIIASTIPVPSG 536
            .|.::.||.|.||::   |...:.::|...     |.:||..|.::.:..|::|:||:|:|:|.|
 Frog   432 RESISVLFDNHTWTKYSGDPSELGRSAAFV-----YPNVFITLPLFFVMKFMMSVIATTMPIPCG 491

  Fly   537 MFIPVFKIGAGFGRLVGEFMAVTFPHGVRYGGRLSPIMPGGYAVVGAAAFSGSVTHTVSVAVIIF 601
            .|:|||.:||.|||||||.||..||:|:.:.|.:..|:||||||:||||.:|:||||||.|||.|
 Frog   492 TFMPVFVLGAAFGRLVGELMAYLFPNGILFDGIVYKIVPGGYAVIGAAALTGAVTHTVSTAVICF 556

  Fly   602 EMTGQITHVVPVMIAVLVANAVAALLQPSIYDSIILIKKLPYLPDLLPSSSGMYSIFVEDFMVRD 666
            |:||||:|::|::|:|::||.||..||||:|||||..|:|||||||.......|:|||||.||||
 Frog   557 ELTGQISHILPMLISVIMANVVAQNLQPSLYDSIIQTKRLPYLPDLSSCHVSKYNIFVEDIMVRD 621

  Fly   667 VKYIWHGISYQKLKEVLKLNKTLRSLPLVDSPDNMILLGSVQRYELIKMIEKHIGREKRMEVAQ- 730
            :.||....||..|.:||: :.|.:::|||:|.|:|:|||||:|.|:..::|:.:.||:|..:|.
 Frog   622 IHYITSCCSYGDLLKVLQ-SCTHKTMPLVESADSMVLLGSVERSEITALLERLLSRERREHLASP 685

  Fly   731 --KWQKEA--------------QERALEEEKKKQEVELKMRRPSRFEVLPAPDILSLRQIANDEM 779
              :.|:.|              :|.|.|||:||:.||
 Frog   686 PYRGQRAADVAGKRDSFKYVDEEETAGEEEEKKEPVE---------------------------- 722

  Fly   780 LPPKKRAETMHGSLAPRKSILKKTNSFNLKTYAQPMGHSPSITPYTTITGNSEFRIRSAFEAIFK 844
                                  :.|
 Frog   723 ----------------------ECN---------------------------------------- 725

  Fly   845 KSTTLQDVQPDPETGSLSPAASNHEVEVPRTPSTPGVSKKVQLPAQSNWDFVTDQIMLQVNPIST 909
                             .|..||:.||.|..|:.|
 Frog   726 -----------------GPIPSNNTVEPPSPPAQP------------------------------ 743

  Fly   910 ESNKMPAEKDFTDKALSNNGDSSKQSPSIKFKANKVADVNRSPQTAKRCSKIRFANEVGVNGSPT 974
                                :||                         |.:.|.|..
 Frog   744 --------------------ESS-------------------------CGRFRAAIH-------- 755

  Fly   975 RTKCKIKPENVLGYSIEDVDETTNPESLAESIQKPKSVRLPRERVIDMSPEDQKQWELEEMLKPI 1039
            |..|.              .|...|:   ::.|:|:    |.|   .|:||:...||.:|:.:|.
 Frog   756 RIFCS--------------SEEPKPQ---DTPQEPE----PEE---TMTPEEIAVWEQQELARPA 796

  Fly  1040 DLQKANVHIDPSPFQLVERTSILKVHSLFSMVGINHAYVTKIGRLVGVVGLKELRKAIEDINSNS 1104
            ...  :..|||||||||||||:.|.|:|||::|::.||:|..|:|.||:.||||:||||. .:.|
 Frog   797 SFD--SCLIDPSPFQLVERTSLHKTHTLFSLLGLSQAYITHGGKLRGVIALKELQKAIEG-TAQS 858

  Fly  1105 FV---PPT---RD------EDADEKPAVEKPLLSTNSSDKAV---DMT-VTSMDSALSN-----S 1148
            .|   ||.   ||      :....:||.:.|    .|.|.::   |.| :.:.||.|.:     |
 Frog   859 GVRLRPPLASFRDGRRSMSQKNSHRPAPKSP----PSPDPSMLPDDPTNLATPDSELDDLSGQGS 919

  Fly  1149 ENCSDIEME-HI--KHTDK 1164
            ||.|.|..: |:  :|:|:
 Frog   920 ENVSQILKDFHVSTEHSDE 938

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	258/477 (54%)
		CBS_pair_SF	659..>718	CDD:449531	28/58 (48%)
		CBS repeat	664..715	CDD:341358	24/50 (48%)
		CBS_pair_SF	<1032..1096	CDD:449531	32/63 (51%)
		CBS repeat	1053..1095	CDD:341358	25/41 (61%)
clcn1	XP_031761520.1	ClC_1_like	128..601	CDD:239655	258/477 (54%)
		CBS_pair_voltage-gated_CLC_euk_bac	614..851	CDD:341367	103/453 (23%)
		CBS repeat	619..802	CDD:341367	69/399 (17%)
		CBS repeat	808..850	CDD:341367	25/41 (61%)