Protein Alignment ClC-a and XB22062446

DIOPT Version :10

• Sequence 1: NP_788639.1
• Gene: ClC-a / 41428
• FlyBaseID: FBgn0051116
• Length: 1193
• Species: Drosophila melanogaster
• Sequence 2: XP_002934155.3
• Gene: XB22062446 / 100488828
• XenbaseID: XB-GENE-22062447
• Length: 818
• Species: Xenopus tropicalis
• Alignment Length: 791
• Identity: 181/791 - (22%)
• Similarity: 316/791 - (39%)
• Gaps: 151/791 - (19%)

  Fly   116 LGEF-AKDEARKLKILEKRRKQEDKQRNKELLGKHSTRAKRVSSWIWRHTVARLGEDWVFLALLG 179
            |.|| ..|:.....|..|:::.::...:...|..||...|   :|:....:....:.|..:.|:|
 Frog    30 LDEFDGMDQHMSNGICHKKKEFQETPESLNYLPSHSEAYK---TWLEEKPLGSDWDRWFMMGLIG 91

  Fly   180 IIMALLSFIMDKGISICTNARIWLYRD-LTSQPFVQYIAWV---SLPVCLILFSAGFVHLIAPQS 240
            :.:.:..|:|.:.|......:..|..: :.:..|:  ..|:   .:...::|.|:|.|....|..
 Frog    92 VFVGIFGFLMHQIIDFLFEMKWELVENYIQNNDFL--TTWMVIAGIGFAMMLVSSGLVVFFCPSG 154

  Fly   241 IGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLGKEGPFVHIASIVAQLLSKLVT 305
            ..||:||:...|.|..::.....:|...........:.:|:..|.|.|.:|:.:.:...||:..:
 Frog   155 SPSGLPEVIGYLNGASIRHIFNIRTFFGSFFSCALAVSAGLFCGPEAPMIHVGAAIGCGLSQFKS 219

  Fly   306 S-------FQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTTTYFAVRNYWRGFFAA 363
            .       |...:.|.:...:.:.|..|.|:.:.|.|||||:||.:|...:::.|:..|:.||..
 Frog   220 DTLRINLPFFTRFRNSADKRQFITAGAAAGIASVFRAPVGGLLFVLEEVASFWDVKLAWQTFFCC 284

  Fly   364 VCGATVFRLLAVWFQNAD----------TVRALFLTNFTTEFPFDPQELFVFALI-----GLVCG 413
            :.......:|:..|...:          ..|.:|...       |...:.|.|:|     |::.|
 Frog   285 LVATFTTEVLSSSFVGFEYEGYFGFFKAEQRIIFWVK-------DLLNISVLAVIPTIILGIIGG 342

  Fly   414 LGGASYVWVHRRYVLFMRSNK-RM-------NKFLQKNRFLYPGFLALLV------------SSI 458
            |.||.:|:::      :|.|| ||       :|||::...|....|.|:|            |..
 Frog   343 LLGALFVFIN------VRINKLRMKIFTSVPHKFLRQLTKLLDTLLILVVTITVTVYIPYFFSCS 401

  Fly   459 SFPLGTGQFLAGELSTHEQVTQLFSNFTWSRDDLTVEQAAVVTHWMTSYTSVFGN---------- 513
            ..|..:....|.|...|.:      :..|   |::.......:.|:....|:..|
 Frog   402 PNPTASQVQNASEHKPHGE------HAAW---DVSEYNCPPGSSWVAPNGSIMANHSINQAAVLL 457

  Fly   514 ------------------------LVIYTLFTFVVSIIASTIPVPSGMFIPVFKIGAGFGRLVGE 554
                                    |::..:|.|.:|...:.....:|:.:|:...||.||||||.
 Frog   458 VKNGKQGTMLLYQRGSHEKFGLPALLMALIFYFTISCWTAGTAAGTGLVVPMVYTGALFGRLVGL 522

  Fly   555 FMAVTFPHGVR---YGGRLSPIMPGGYAVVGAAAFSGSVTH-TVSVAVIIFEMTGQITHVVPVMI 615
            .|...|  ||:   ||..:.   ||.:||:|:||:.|.||. |:|:.||:.|:|..:..::.:||
 Frog   523 IMVAMF--GVQTDEYGAWID---PGLFAVIGSAAYFGGVTRLTISLTVIMVEITNDVQSILLIMI 582

  Fly   616 AVLVANAVAALLQPSIYDSIILIKKLPYLPDLLPSSSGMYSIFVEDFMVRDVKYIWHGISYQK-- 678
            ||||...|......|::.|::.:|.:|||..:.....|...:.:|.|..|||......|..|:
 Frog   583 AVLVGKTVGDYFNNSLFSSLLHLKCIPYLKAVPNVVHGKKKVNLELFTARDVMQSCTTIHLQENV 647

  Fly   679 --LKEVLKLNKTLRSLPLVDSP---DNMILLGSVQRYELIKMIEKHIGREKRMEVAQKWQKEAQE 738
              |.|:|. ..:....|:|.||   ...:.||::.|.||..::       ....|.|..:.....
 Frog   648 FLLAELLS-TTSHNGFPVVFSPAPGQEEVFLGTITRLELYMLL-------SNSRVFQTPENNQCS 704

  Fly   739 RALEEEKKKQEVELKMRRPSRFEVLPAPDILSLRQIANDEMLPPKKRAETMHGSLAP--RKSILK 801
            ..|    |.|||.::          ..||...:.::.|.....|  :.:.:..:|.|  .||.:.
 Frog   705 SVL----KYQEVTVE----------KLPDEAQINRLLNKYSADP--QYQQLFINLEPYINKSAVS 753

  Fly   802 KTNSFNL-KTY 811
            ....|:| :||
 Frog   754 VQAHFSLQRTY 764

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	131/558 (23%)
		CBS_pair_SF	659..>718	CDD:449531	19/65 (29%)
		CBS repeat	664..715	CDD:341358	17/57 (30%)
		CBS_pair_SF	<1032..1096	CDD:449531
		CBS repeat	1053..1095	CDD:341358
XB22062446	XP_002934155.3	Voltage_gated_ClC	56..618	CDD:445960	136/593 (23%)
		CBS_pair_voltage-gated_CLC_euk_bac	630..793	CDD:341367	36/159 (23%)
		CBS repeat	636..746	CDD:341367	26/133 (20%)
		CBS repeat	752..793	CDD:341367	4/13 (31%)