Protein Alignment Sbf and SBF2

DIOPT Version :10

• Sequence 1: NP_477401.2
• Gene: Sbf / 41427
• FlyBaseID: FBgn0025802
• Length: 1993
• Species: Drosophila melanogaster
• Sequence 2: NP_001373268.1
• Gene: SBF2 / 81846
• HGNCID: 2135
• Length: 1881
• Species: Homo sapiens
• Alignment Length: 2065
• Identity: 842/2065 - (40%)
• Similarity: 1210/2065 - (58%)
• Gaps: 260/2065 - (12%)

  Fly     1 MSRLADYFVIVGYDSDKEKTASNVGGQPTCGKIVQRFPEKDWPDTPFIEGIEWFCQPLGWSLSYE 65
            |:||||||::|||  |.||..|..|    .|||:||||:|||.||||.:|||.||||.||.||.|
Human     1 MARLADYFIVVGY--DHEKPGSGEG----LGKIIQRFPQKDWDDTPFPQGIELFCQPGGWQLSRE 59

  Fly    66 KQEPKFFVSVLTDIDANKHYCACLSFHET-VAITQTRSVDDEDETIGSSRLLGATPSSMDGITTT 129
            :::|.|||.||||||:::|||:||:|:|. :.:..|:    ::|..|.:::.|..
Human    60 RKQPTFFVVVLTDIDSDRHYCSCLTFYEAEINLQGTK----KEEIEGEAKVSGLI---------- 110

  Fly   130 STPASITHHSVMYAPKCLVLISRLDCAETFKNCLGTIYTVYIENLAYGLETLIGNILGCIQVPPA 194
             .||.:      :|||.|||:|||...|.|:.|||.|||||:::|...||:||.|:..|: ||.|
Human   111 -QPAEV------FAPKSLVLVSRLYYPEIFRACLGLIYTVYVDSLNVSLESLIANLCACL-VPAA 167

  Fly   195 GGPQVRFSIGAGDKQSLQPPQSSSLPTTGSGVHFLFKQLGIKNVLILLCSVMTENKILFLSKCYW 259
            ||.|..||:||||:|.:|.|...|||.||:.|..||:||||:|||.|.|:|:||||:||.|..:.
Human   168 GGSQKLFSLGAGDRQLIQTPLHDSLPITGTSVALLFQQLGIQNVLSLFCAVLTENKVLFHSASFQ 232

  Fly   260 HLTDSCRALVALMYPFRYTHVYIPILPAPLTEVLSTPTPFIMGIHSSLQTEITDLLDVIVVDLDG 324
            .|:|:||||.:||:|.:|::.|||||||.|.||||:|||||:|:||..:|::.:|||||:.||||
Human   233 RLSDACRALESLMFPLKYSYPYIPILPAQLLEVLSSPTPFIIGVHSVFKTDVHELLDVIIADLDG 297

  Fly   325 GLVTIPESLTPPVPILPSPLWEQTQDLLSMILFPNLAQADLAFPTLERPSAIAKTDAQIDKELRA 389
            |.:.|||.:  .:..||.||..|||..||:||.|:|..||.|||.   |.........:|||:||
Human   298 GTIKIPECI--HLSSLPEPLLHQTQSALSLILHPDLEVADHAFPP---PRTALSHSKMLDKEVRA 357

  Fly   390 IFMRLFAQLLQGYRSCLTIIRIHPKPVITFHKAGFLGARDLIESEFLFRVLDSMFFTTFVNERGP 454
            :|:||||||.|||||||.:||||.:|||.|||..|||.|.|:|::||.:||..|.|..||:||||
Human   358 VFLRLFAQLFQGYRSCLQLIRIHAEPVIHFHKTAFLGQRGLVENDFLTKVLSGMAFAGFVSERGP 422

  Fly   455 PWRSSDAWDELYSSMNELLKSEAQNRNLVGRTQRFKGYFNFTFPSYFQILTHIQELGRVLYENEG 519
            |:||.|.:|||.:...|.:|.|..|.                    .:::.|::||...|::||.
Human   423 PYRSCDLFDELVAFEVERIKVEENNP--------------------VKMIKHVRELAEQLFKNEN 467

  Fly   520 TLAHISYAQKVLRPPEGAFQRIHQPAFPRISSEKVELIIQEGIRKN-GVPQRFHVTRNQHR-IIP 582
            ...|::: |||.||.||:..|:|...||.|:..:|:.:|||.:.|| ..|.   .||.:.: ::|
Human   468 PNPHMAF-QKVPRPTEGSHLRVHILPFPEINEARVQELIQENVAKNQNAPP---ATRIEKKCVVP 528

  Fly   583 MGPRLPEALDVRPNVQNSARRLEVLRICVSYIFENRITDARKLLPAVMRTLMHRDARLILCREFF 647
            .||.:...:|....|.|||:||||:|.|:|:||||:|.:..|.|||.:|.|..:.||..|..|..
Human   529 AGPPVVSIMDKVTTVFNSAQRLEVVRNCISFIFENKILETEKTLPAALRALKGKAARQCLTDELG 593

  Fly   648 GYVHGNKAVLDHQQFELVVRFMNKALQKSSGIDEYTVAAALLPMSTIFCRKLSTGVVQFAYTEIQ 712
            .:|..|:|:||||||:.::|.||..||..|.::||.:||||||:::.|.|||:.||.|||||.:|
Human   594 LHVQQNRAILDHQQFDYIIRMMNCTLQDCSSLEEYNIAAALLPLTSAFYRKLAPGVSQFAYTCVQ 658

  Fly   713 DHAIWKNLQFWESTFFQDVQGQIKALYLLHRRQNE--HQKEANCVLDEVP---LEEPTALEITAE 772
            ||.||.|.||||:||:..||.|:::|||..:..|.  |.|:.    |::|   .:|.||:::.||
Human   659 DHPIWTNQQFWETTFYNAVQEQVRSLYLSAKEDNHAPHLKQK----DKLPDDHYQEKTAMDLAAE 719

  Fly   773 QLRKSPNIEEEKKAELAKSEESTLYSQAIHFANRMVSLLIPLDVNVDAASKPKPAFRLE--ENQS 835
            |||..|.:.:..:.||.:.||||::||||||||.||:||:|||.:.:...:.......|  .|..
Human   720 QLRLWPTLSKSTQQELVQHEESTVFSQAIHFANLMVNLLVPLDTSKNKLLRTSAPGDWESGSNSI 784

  Fly   836 VSNSIMGSHSLSEHSDEGFEENNALEIGVTVGKTISRFIDCVCTEGGVTSEHIRNLHDMVPGVVH 900
            |:|||.||.:.|..::.|||::...:|..:|.:.|:||||.||||.|||.:||::||.|:||:|.
Human   785 VTNSIAGSVAESYDTESGFEDSENTDIANSVVRFITRFIDKVCTESGVTQDHIKSLHCMIPGIVA 849

  Fly   901 MHIESLEPVYLEAKRHPHVQKPKIQTPCLLPGEDLVTDHLRCFLMPDGREDET------QCLIPA 959
            ||||:||.|:.|::|.|.:|||||..|.|||||::|.:.||..|.|||||:.|      ..|:||
Human   850 MHIETLEAVHRESRRLPPIQKPKILRPALLPGEEIVCEGLRVLLDPDGREEATGGLLGGPQLLPA 914

  Fly   960 EGALFLTNYRVIFKGSPCDPLFCEQVIVRTFPIASLLKEKKISVLYLAHLDQTLTEGLQLRSSSF 1024
            |||||||.||::|:|:|.|.|..||.:||:|||||:.|||||::  ...|.|.:.||||:.|:||
Human   915 EGALFLTTYRILFRGTPHDQLVGEQTVVRSFPIASITKEKKITM--QNQLQQNMQEGLQITSASF 977

  Fly  1025 QLIKVAFDPEVTPEQIESFRKILSKARHPFDEFEYFAFQSYGTMLQGVAPLKTKEKYSTLKGFAK 1089
            ||||||||.||:||.:|.|:|.|.|.|:|...|..|||.:..|..|.:.| |.|||.::.:.|:
Human   978 QLIKVAFDEEVSPEVVEIFKKQLMKFRYPQSIFSTFAFAAGQTTPQIILP-KQKEKNTSFRTFS- 1040

  Fly  1090 KTLLRGAKKAGFKQKQQTKRKLVSDYDYGSADAQETQ----SIDDELEDGDEFETQNNAMPRLLT 1150
            ||:::|||:||   |....|:.:.....|:...:...    :.||::...||.|...:...:...
Human  1041 KTIVKGAKRAG---KMTIGRQYLLKKKTGTIVEERVNRPGWNEDDDVSVSDESELPTSTTLKASE 1102

  Fly  1151 TKDVERMRERSYVQDWKRLG---FDAESQRG----FRISNANTSYATCRSYPAIIVAPVQCSDAA 1208
            ...:|::.|::..:|::|||   ....|.|.    |||:.:|..|:.|||||.::|.|....|::
Human  1103 KSTMEQLVEKACFRDYQRLGLGTISGSSSRSRPEYFRITASNRMYSLCRSYPGLLVVPQAVQDSS 1167

  Fly  1209 IMHLGRCFKGQRIPLPTWRHA-NGALLIRGGQPNSKSVIGMLK--NTTGSTTNAHHDVTHYPEQD 1270
            :..:.||::..|:|:..|::: :|.||:|.|..:.|.|:|:.|  |:..:...:..:.:...||:
Human  1168 LPRVARCYRHNRLPVVCWKNSRSGTLLLRSGGFHGKGVVGLFKSQNSPQAAPTSSLESSSSIEQE 1232

  Fly  1271 KYFLALINTMPKLTPLALNQYSGMNLSMSSLMGHSSSDDRQP--LTPELSRKHKNNLDISDGNKS 1333
            ||..||:|.:.....|..|.    .|::......|...:|:.  ::..|.:....:||::..|..
Human  1233 KYLQALLNAVSVHQKLRGNS----TLTVRPAFALSPGTERRTSRMSTVLKQVVPGHLDVNPSNSF 1293

  Fly  1334 SQGGKGGTMKGNPK-------------------------------NSLAHPFRKMRLYALGEKSQ 1367
            :|||...:::.:.:                               |.|..  |:..||..|||||
Human  1294 AQGGVWASLRSSTRLISSPTSFIDVGARLAGKDHSASFSNSSYLQNQLLK--RQAALYIFGEKSQ 1356

  Fly  1368 AKSNMNVDFC--ADFIPVDYPDIRQSRPAFKKLIRACMPSHNTNEADGQ-SFAKMVEQSDWLQQI 1429
            .: |..|:|.  .:|:||::.:|||.:.:||||:|||:||  |...|.: :|.|.:..|:|..|:
Human  1357 LR-NFKVEFALNCEFVPVEFHEIRQVKASFKKLMRACIPS--TIPTDSEVTFLKALGDSEWFPQL 1418

  Fly  1430 SSLMQLSGAVVDLIDLQESSVMLSLEDGSDVTAQLSSIAQLCLDPYYRSLDGFRVLVEKEWLAFG 1494
            ..:|||:..|.:::: ..|||::.||:|.|:|||::|:.||..||:||:|:||::|||||||:||
Human  1419 HRIMQLAVVVSEVLE-NGSSVLVCLEEGWDITAQVTSLVQLLSDPFYRTLEGFQMLVEKEWLSFG 1482

  Fly  1495 HRFAHRSNLKPSHANTNIAFAPTFLQFLDVVHQLQRQFPMAFEFNDFYLRFLAYHSVSCRFRTFL 1559
            |:|:.||:|..:...:  .|||.||||||.|||:..|:|..||||.:||:|||:|.||.||:|||
Human  1483 HKFSQRSSLTLNCQGS--GFAPVFLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKTFL 1545

  Fly  1560 FDCELERSDSGIAAMEDKRGSLNAKHMFGAGGMATNGSDDECSVYPLDIRSQRAPAPLNRIGHSI 1624
            .|.:.||.:.|  .:.|.:|..:||.                                   |..|
Human  1546 LDSDYERLEHG--TLFDDKGEKHAKK-----------------------------------GVCI 1573

  Fly  1625 FDYIERQHNKTPIFYNFLYSGDKSVTLRPQNNVAALDLWCYYTNEELAQGAPYDLEVTT----VD 1685
            ::.|:|.|.::|||:|:|||..:...|:|..||::|..|.||..|.|:.|..||..:.|    ..
Human  1574 WECIDRMHKRSPIFFNYLYSPLEIEALKPNVNVSSLKKWDYYIEETLSTGPSYDWMMLTPKHFPS 1638

  Fly  1686 DEIDLSETKG---KRMVITAGYDNMEKCNPSAYVCLLSEVKQAETERGHLPQKWLQVWNSLEVPQ 1747
            ::.||:...|   :|..:...||::....|.|...|.||:::.|.:....|:||.|:|..:.|..
Human  1639 EDSDLAGEAGPRSQRRTVWPCYDDVSCTQPDALTSLFSEIEKLEHKLNQAPEKWQQLWERVTVDL 1703

  Fly  1748 LEPVARNTSLGNIFVQTHQHKRSTLEIIMKGRLAGYQDKYFHPHRFEKHPYTTPTNCNHCTKLLW 1812
            .|....:.|      |.|                           ..:.|....||.
Human  1704 KEEPRTDRS------QRH---------------------------LSRSPGIVSTNL-------- 1727

  Fly  1813 GPVGYRCMDCGNSYHEKCTEHSMKNCTKYKAIDGAVGPPNVNMSQGDTASIASSAATTARTSSHH 1877
                       .||.::...|.                |:.:|.:...:||:.|.....|.::
Human  1728 -----------PSYQKRSLLHL----------------PDSSMGEEQNSSISPSNGVERRAAT-- 1763

  Fly  1878 FYNQFSSNVAENRTHEGHLYKRGALLKGWKQRWFVLDSIKHQLRYYDTSEDTAPKGIIELAEVQS 1942
            .|:|::|...|||:.||.||||||||||||.||||||..||||||||:.|||:.||.|:||||:.
Human  1764 LYSQYTSKNDENRSFEGTLYKRGALLKGWKPRWFVLDVTKHQLRYYDSGEDTSCKGHIDLAEVEM 1828

  Fly  1943 VTAAQPAQIGAKGVDEKGFFDLKTSKRIYNFYAINANLAQEWIEKLQACL 1992
            |..|.|:....|...:|.|||||||||:|||.|.:...||:|::|:|:|:
Human  1829 VIPAGPSMGAPKHTSDKAFFDLKTSKRVYNFCAQDGQSAQQWMDKIQSCI 1878

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sbf	NP_477401.2	uDENN	1..91	CDD:214824	56/89 (63%)
		DENN	142..325	CDD:460461	105/182 (58%)
		dDENN	384..452	CDD:129037	43/67 (64%)
		SBF2	584..807	CDD:463536	109/227 (48%)
		PH-GRAM_MTMR5_MTMR13	933..1047	CDD:275396	66/119 (55%)
		PTP-MTMR5-like	1179..1531	CDD:350382	132/390 (34%)
		C1_Sbf-like	1790..1840	CDD:410377	6/49 (12%)
		PH_Sbf1_hMTMR5	1888..1993	CDD:269941	65/105 (62%)
SBF2	NP_001373268.1	uDENN	1..86	CDD:214824	56/90 (62%)
		DENN	116..298	CDD:460461	105/182 (58%)
		dDENN	352..420	CDD:129037	43/67 (64%)
		SBF2	530..754	CDD:463536	109/227 (48%)
		PH-GRAM_MTMR13	882..1000	CDD:275416	66/119 (55%)
		PTP-MTMR13	1138..1517	CDD:350437	132/390 (34%)
		Required for homodimerization and interaction with MTMR2. /evidence=ECO:0000250|UniProtKB:E9PXF8, ECO:0000269|PubMed:15998640	1661..1714		15/58 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1706..1726		4/52 (8%)
		PH_Sbf1_hMTMR5	1774..1879	CDD:269941	65/105 (62%)