Protein Alignment Sbf and Mtmr6

DIOPT Version :10

• Sequence 1: NP_477401.2
• Gene: Sbf / 41427
• FlyBaseID: FBgn0025802
• Length: 1993
• Species: Drosophila melanogaster
• Sequence 2: NP_726322.1
• Gene: Mtmr6 / 37707
• FlyBaseID: FBgn0028497
• Length: 761
• Species: Drosophila melanogaster
• Alignment Length: 916
• Identity: 178/916 - (19%)
• Similarity: 321/916 - (35%)
• Gaps: 290/916 - (31%)

  Fly  1017 LQLRSSSFQLIKVAFDPEVTPEQIES----------------FRKILSKARHPFDEFEYFAFQSY 1065
            ::.:.|....::::|| .::||..|.                ..|::|.....|:|..  .|.:.
  Fly    13 IERQLSPTSALRLSFD-NISPETEEPPDGNKRLWGVPVPPFVSEKVVSWIEEEFNEAP--VFYNG 74

  Fly  1066 GTMLQGVAPLKTKEKYSTLKGFAKKTLLRGAKKAGFKQKQQTKRKLVSDYDYGSAD--------- 1121
            .::|:.|..::..::|:| |.....||...|....|.:....|...:......|.:
  Fly    75 NSVLKKVENVRMIDRYNT-KNPTVGTLYLTATHLIFVEPDSNKETWILHMHVASIEKLPLSTTGS 138

  Fly  1122 -----AQETQSIDDELEDGDEFETQNNAMPRLLTTKDVERMRERSYVQD---------WKRLGFD 1172
                 .:...|:...:....|......::.:|.....:.::...:|..:         |.....:
  Fly   139 PLLIRCKTFLSVTFVIPKDSECHDVYTSLLKLFQPVSINKLYCFNYQPNKDDFPKNAGWDYFKLE 203

  Fly  1173 AE------SQRGFRISNANTSYATCRSYPAIIVAPVQCSDAAIMHLGRCFKGQRIPLPTWRHANG 1231
            ||      ....:.:.:.|..|..|.:||..|..|.:.:...::...|.....|:|:.|:.|.|.
  Fly   204 AEFKHMLVPNEAWTLCSMNEKYELCDTYPRQIYVPKEATTLMLISSSRFRSKGRLPVLTYLHNNK 268

  Fly  1232 ALLIRGGQPNS---------KSVIGMLKNTTGSTTNAHHDVTHYPEQDKYFLALINTMPKLTPLA 1287
            |.:.|..||.|         :.::..::.|..:|.               ::.:::|.|::..:|
  Fly   269 ASICRCSQPLSGFSARCLEDEQMLEAIRKTNSNTD---------------YMYVVDTRPRINAMA 318

  Fly  1288 LNQYSGMNLSMSSLMGHSSSDDRQPLTPELSRKHKNNLDISDGNKSSQGGKGGTMKGNPKNSLAH 1352
                                                       |:::  |||
  Fly   319 -------------------------------------------NRAA--GKG------------- 325

  Fly  1353 PFRKMRLYALGEKSQAKSNMNVDFCADFIPVDYPDIRQSRPAFKKLIRACMPSHNTNEADGQSFA 1417
             :.....|.           |:.|  .|:.::  :|...|.:.:|::.||.....|..|    |.
  Fly   326 -YENEAFYE-----------NIKF--HFLGIE--NIHVQRASLQKVLEACEQKSPTMSA----FI 370

  Fly  1418 KMVEQSDWLQQISSLMQLSGAVVDLIDLQESSVMLSLEDGSDVTAQLSSIAQLCLDPYYRSLDGF 1482
            ..:|.|.||:.|.|::..|..:.:.:| :..||::...||.|.|||:.|:|||.|:||||::.||
  Fly   371 NALESSGWLKHIRSILDTSSFIANAVD-KGVSVVVHCSDGWDRTAQVCSLAQLMLNPYYRTIKGF 434

  Fly  1483 RVLVEKEWLAFGHRFAHRSNLKPSHANTNI-AFAPTFLQFLDVVHQLQRQFPMAFEFNDFYLRFL 1546
            :.|:||:||||||:|:.|.    .|..|:. ..:|.|.||||...||..|...|||||:.:|..|
  Fly   435 QALIEKDWLAFGHKFSERC----GHIQTDAREVSPIFTQFLDCTWQLMSQRSEAFEFNERFLLIL 495

  Fly  1547 AYHSVSCRFRTFLFDCELERSDSGIAAMEDKRGSLNAKHMFGAGGMATNGSDDECSVYPL----- 1606
            ..|..||:|.||:.:||.:|.|..:           |:..|...|...|..::  .:.||
  Fly   496 HDHVHSCQFGTFVGNCEKDRLDLKL-----------AERTFSLWGYMANHLNE--YINPLYKPNV 547

  Fly  1607 --DIRSQRAPA-----------------PLNRIG----------HSIFDYIERQHNKTPIFYNFL 1642
              .|::..||.                 |...:|          :|:.|:::....:...|.|::
  Fly   548 DEAIKANLAPQCIKFWRGMYSRFESGIHPREPLGDVLLDSKEHCNSLEDHVQHLTKRIASFKNYI 612

  Fly  1643 YSGDKSVTLRPQNNVAALDLWCYYTNEELAQGAPYDLEVTTVDDEIDLSETKGKRMVITAGYDNM 1707
            ....|.:                    :.|..||     ..|:.|:..:|....:.    .||..
  Fly   613 SKSAKKL--------------------QDATSAP-----GKVNKELSSNEINDNKY----NYDKK 648

  Fly  1708 EKCNPSAYVCLLSEVKQAETERGHLPQKWLQVWNSLEVPQLEPVARNTSLGNIFVQTHQ------ 1766
                       |||:..|:.:.   |.|                |.|.|..::.:...|
  Fly   649 -----------LSELSAADDDH---PLK----------------ASNMSFASLSLSAEQSSPPQA 683

  Fly  1767 --HKRSTLEIIMKGRLAGYQDKYFHPHRFEKHPYTTPTNCNHCTKLLWGPVGYRCMDCGNSYHEK 1829
              .:.:::.:..|                   |....|.|:..|..........|..||:.:.|:
  Fly   684 LPEEINSVAVDWK-------------------PMRNVTTCSCSTPFDQFSKKTHCWRCGDIFCER 729

  Fly  1830 CTEHSM 1835
            |.:.::
  Fly   730 CIDKNV 735

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sbf	NP_477401.2	uDENN	1..91	CDD:214824
		DENN	142..325	CDD:460461
		dDENN	384..452	CDD:129037
		SBF2	584..807	CDD:463536
		PH-GRAM_MTMR5_MTMR13	933..1047	CDD:275396	7/45 (16%)
		PTP-MTMR5-like	1179..1531	CDD:350382	87/361 (24%)
		C1_Sbf-like	1790..1840	CDD:410377	9/46 (20%)
		PH_Sbf1_hMTMR5	1888..1993	CDD:269941
Mtmr6	NP_726322.1	PH-GRAM_MTMR6-like	78..173	CDD:270030	14/95 (15%)
		PTP-MTMR6-like	202..501	CDD:350380	98/396 (25%)
		FYVE_MTMR_unchar	693..753	CDD:277277	10/62 (16%)