DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sbf and CG3530

DIOPT Version :9

Sequence 1:	NP_477401.2	Gene:	Sbf / 41427	FlyBaseID:	FBgn0025802	Length:	1993	Species:	Drosophila melanogaster
Sequence 2:	NP_726322.1	Gene:	CG3530 / 37707	FlyBaseID:	FBgn0028497	Length:	761	Species:	Drosophila melanogaster

Alignment Length:	916	Identity:	178/916 - (19%)
Similarity:	321/916 - (35%)	Gaps:	290/916 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1017 LQLRSSSFQLIKVAFDPEVTPEQIES----------------FRKILSKARHPFDEFEYFAFQSY 1065
            ::.:.|....::::|| .::||..|.                ..|::|.....|:|..  .|.:.
  Fly    13 IERQLSPTSALRLSFD-NISPETEEPPDGNKRLWGVPVPPFVSEKVVSWIEEEFNEAP--VFYNG 74

  Fly  1066 GTMLQGVAPLKTKEKYSTLKGFAKKTLLRGAKKAGFKQKQQTKRKLVSDYDYGSAD--------- 1121
            .::|:.|..::..::|:| |.....||...|....|.:....|...:......|.:
  Fly    75 NSVLKKVENVRMIDRYNT-KNPTVGTLYLTATHLIFVEPDSNKETWILHMHVASIEKLPLSTTGS 138

  Fly  1122 -----AQETQSIDDELEDGDEFETQNNAMPRLLTTKDVERMRERSYVQD---------WKRLGFD 1172
                 .:...|:...:....|......::.:|.....:.::...:|..:         |.....:
  Fly   139 PLLIRCKTFLSVTFVIPKDSECHDVYTSLLKLFQPVSINKLYCFNYQPNKDDFPKNAGWDYFKLE 203

  Fly  1173 AE------SQRGFRISNANTSYATCRSYPAIIVAPVQCSDAAIMHLGRCFKGQRIPLPTWRHANG 1231
            ||      ....:.:.:.|..|..|.:||..|..|.:.:...::...|.....|:|:.|:.|.|.
  Fly   204 AEFKHMLVPNEAWTLCSMNEKYELCDTYPRQIYVPKEATTLMLISSSRFRSKGRLPVLTYLHNNK 268

  Fly  1232 ALLIRGGQPNS---------KSVIGMLKNTTGSTTNAHHDVTHYPEQDKYFLALINTMPKLTPLA 1287
            |.:.|..||.|         :.::..::.|..:|.               ::.:::|.|::..:|
  Fly   269 ASICRCSQPLSGFSARCLEDEQMLEAIRKTNSNTD---------------YMYVVDTRPRINAMA 318

  Fly  1288 LNQYSGMNLSMSSLMGHSSSDDRQPLTPELSRKHKNNLDISDGNKSSQGGKGGTMKGNPKNSLAH 1352
                                                       |:::  |||
  Fly   319 -------------------------------------------NRAA--GKG------------- 325

  Fly  1353 PFRKMRLYALGEKSQAKSNMNVDFCADFIPVDYPDIRQSRPAFKKLIRACMPSHNTNEADGQSFA 1417
             :.....|.           |:.|  .|:.::  :|...|.:.:|::.||.....|..|    |.
  Fly   326 -YENEAFYE-----------NIKF--HFLGIE--NIHVQRASLQKVLEACEQKSPTMSA----FI 370

  Fly  1418 KMVEQSDWLQQISSLMQLSGAVVDLIDLQESSVMLSLEDGSDVTAQLSSIAQLCLDPYYRSLDGF 1482
            ..:|.|.||:.|.|::..|..:.:.:| :..||::...||.|.|||:.|:|||.|:||||::.||
  Fly   371 NALESSGWLKHIRSILDTSSFIANAVD-KGVSVVVHCSDGWDRTAQVCSLAQLMLNPYYRTIKGF 434

  Fly  1483 RVLVEKEWLAFGHRFAHRSNLKPSHANTNI-AFAPTFLQFLDVVHQLQRQFPMAFEFNDFYLRFL 1546
            :.|:||:||||||:|:.|.    .|..|:. ..:|.|.||||...||..|...|||||:.:|..|
  Fly   435 QALIEKDWLAFGHKFSERC----GHIQTDAREVSPIFTQFLDCTWQLMSQRSEAFEFNERFLLIL 495

  Fly  1547 AYHSVSCRFRTFLFDCELERSDSGIAAMEDKRGSLNAKHMFGAGGMATNGSDDECSVYPL----- 1606
            ..|..||:|.||:.:||.:|.|..:           |:..|...|...|..::  .:.||
  Fly   496 HDHVHSCQFGTFVGNCEKDRLDLKL-----------AERTFSLWGYMANHLNE--YINPLYKPNV 547

  Fly  1607 --DIRSQRAPA-----------------PLNRIG----------HSIFDYIERQHNKTPIFYNFL 1642
              .|::..||.                 |...:|          :|:.|:::....:...|.|::
  Fly   548 DEAIKANLAPQCIKFWRGMYSRFESGIHPREPLGDVLLDSKEHCNSLEDHVQHLTKRIASFKNYI 612

  Fly  1643 YSGDKSVTLRPQNNVAALDLWCYYTNEELAQGAPYDLEVTTVDDEIDLSETKGKRMVITAGYDNM 1707
            ....|.:                    :.|..||     ..|:.|:..:|....:.    .||..
  Fly   613 SKSAKKL--------------------QDATSAP-----GKVNKELSSNEINDNKY----NYDKK 648

  Fly  1708 EKCNPSAYVCLLSEVKQAETERGHLPQKWLQVWNSLEVPQLEPVARNTSLGNIFVQTHQ------ 1766
                       |||:..|:.:.   |.|                |.|.|..::.:...|
  Fly   649 -----------LSELSAADDDH---PLK----------------ASNMSFASLSLSAEQSSPPQA 683

  Fly  1767 --HKRSTLEIIMKGRLAGYQDKYFHPHRFEKHPYTTPTNCNHCTKLLWGPVGYRCMDCGNSYHEK 1829
              .:.:::.:..|                   |....|.|:..|..........|..||:.:.|:
  Fly   684 LPEEINSVAVDWK-------------------PMRNVTTCSCSTPFDQFSKKTHCWRCGDIFCER 729

  Fly  1830 CTEHSM 1835
            |.:.::
  Fly   730 CIDKNV 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sbf	NP_477401.2	uDENN	1..91	CDD:214824
		DENN	142..325	CDD:280329
		dDENN	384..452	CDD:129037
		SBF2	585..807	CDD:289132
		PH-GRAM_MTMR5_MTMR13	933..1047	CDD:275396	7/45 (16%)
		Myotub-related	1161..1565	CDD:284109	107/428 (25%)
		C1	1791..1838	CDD:237996	9/45 (20%)
		PH_Sbf1_hMTMR5	1888..1993	CDD:269941
		PH	1891..1992	CDD:278594
CG3530	NP_726322.1	PH-GRAM_MTMR6-like	78..173	CDD:270030	14/95 (15%)
		Myotub-related	179..514	CDD:284109	107/432 (25%)
		FYVE_MTMR_unchar	693..753	CDD:277277	10/62 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462311
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10807
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940