Protein Alignment prd1 and Plekhm2

DIOPT Version :10

• Sequence 1: NP_650115.1
• Gene: prd1 / 41425
• FlyBaseID: FBgn0037949
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_001178696.1
• Gene: Plekhm2 / 313667
• RGDID: 1307005
• Length: 1031
• Species: Rattus norvegicus
• Alignment Length: 1057
• Identity: 199/1057 - (18%)
• Similarity: 359/1057 - (33%)
• Gaps: 303/1057 - (28%)

  Fly   362 DNSSKMIFGSLKSIFTMPLPERGVPEGSEDLQ--AVVECVPELEQT-------------PEH--- 408
            |:.|...|.|:.|. .:...:..:...|||..  .|...||.:..|             |..
  Rat   190 DSLSLNSFNSVTST-NLEWDDSAIAPSSEDYDFGDVFPAVPSVPSTDWEDGDLTDTISGPRSTAS 253

  Fly   409 ---KSRPAAESPPLRAKPFLSKSLD-GSKQAQPVKKFVHNVD---EQLRHKNEDDGASSTEASPM 466
               .|:.:.:||..|..||..:..: .|.:..|    ||...   |:.:..::.|..:..|...:
  Rat   254 DLTSSKASTKSPTQRHNPFNEEQAESASSETTP----VHTTSQEKEEAQAPDQPDACTELEVIRV 314

  Fly   467 ESKQSLMLHRQEEFDKETVPM------------GSAQGEFRSKFII-NCESTVFEHTGVSYETGD 518
            ..|:.:...::.:.|:|..|:            |...|...:..:. ||..|:.   ....|.|:
  Rat   315 TKKKKIGKKKKTKLDEEASPLHPNCSQQKCGRQGDGDGLVGTPGLARNCSDTIL---ASPQEQGE 376

  Fly   519 LQSELSSGIQHTSVASLLEQNTPIAEPAASQIKKSFLDAPIAKTFSNFFRSFKDSTPVAKDEQAV 583
            .....:...:|:.::.:     .:..|.........|..|::|......
  Rat   377 GPGSTAGSCEHSELSQM-----GLLIPEMKDTSMECLGQPLSKVIDQLH---------------- 420

  Fly   584 TDNYFASKIAKPQQQAPAAGKLQRNFSSSTISEPSSNTNTSSNHQIAMNPQLGNAERQSRHLPSP 648
                               |:|..:...|.:..|..:..|.|..:....|...:.   |..||:|
  Rat   421 -------------------GQLDPSTWCSRVEPPDQSFRTGSPGEAPEKPPFCDF---SEGLPAP 463

  Fly   649 LKKRGQPLQPPR-------YYDQQHPHQSRSLHSPSAYLAAGRGGPGGSGRDSKSTILSEEFDDI 706
            :......::.|.       ::|.  |..|:.||.|.:...|.:...||.|....|..|.::....
  Rat   464 MDFYRFTVESPSTVAPGGGHHDP--PGSSQPLHVPGSPAPALQEEEGGRGEGQTSQPLEDQQGKE 526

  Fly   707 LTITTTDTTNARSMDSDLVIVDYTDVDYAHLLKPPAPAAKTSLINRFLRNVTQKK--IMETSIRK 769
            :     .....:..||.|.:|.          :.|.|           ..|:|.:  ..||..:
  Rat   527 I-----QEPEPQEPDSQLPLVS----------QEPGP-----------EPVSQPEPGTQETLCK- 564

  Fly   770 NNFFADKLRTEQRHAGSDLYVKGARPKN-YELIDDLNAEIAMEIEMCGTNSPRRELAISLDNDFQ 833
                                :||.:|.. ....:|...:.       |..||..   ::..::|:
  Rat   565 --------------------LKGDQPSPCLSSAEDSGVDE-------GQGSPSE---MTHPSEFR 599

  Fly   834 GNLSNFELGIGEISIDVFKGKSLFNLKQSNEQLMKAFKLYTGYNVDGIMTPVLVLLTDKTLYVVN 898
            .:.::..|    :.|.||        :::.|||.|..::.||: ::|.:..:.|||||..:|::.
  Rat   600 VDNNHLLL----LMIHVF--------RENEEQLFKMIRMSTGH-MEGNLQLLYVLLTDCYVYLLR 651

  Fly   899 MEGNS--LCVKFVLAYKDLDVILMGPFGNTVLLSNSNRDMQQVLLAGGPYPAGSLVANLELCARR 961
            .....  ..|:..::|.:||.:.:|....||.|..:||..|.:|.......|...:|:|: .|..
  Rat   652 KGATEKPYLVEEAVSYNELDYVSVGLDQQTVKLVCTNRRKQFLLDTADVALAELFLASLK-SAMI 715

  Fly   962 SGSTLP----AVGQLTLEHLAPLQAFVRANSCVGVAEHWMLYAVVNVPAGGSMRVESP-SELLGP 1021
            .|...|    .:...|:|.||..:...:.:.|..        :.|.|...|.:..|.| .|.|||
  Rat   716 KGCREPPYPSVLTDATMERLALAKFVAQESKCEA--------STVTVHFYGLVHWEDPMEEALGP 772

  Fly  1022 ------------SMKGFLMHRRLRQTISTSAANRIFWQPGYFLLKAGVLYMFNDSTQRLP--SWA 1072
                        :.:|.|.::     .|||...:..|:..:.:|..|:||.:.|.|..:|  |..
  Rat   773 VPCQCSPAEGTITKEGMLHYK-----ASTSYLGKEHWKACFVVLSNGILYQYPDRTDVIPLLSVN 832

  Fly  1073 MALAECQGARRTVKSERPHCFEITLKGE-VLQMAAPDEYVASEWLQALLQSASGLVVQE--EKHK 1134
            |...:|.|.||:..::|||.|::.|... .|:::|..|...::|:|.|.|:.|..|:.:  ....
  Rat   833 MGGEQCGGCRRSNTTDRPHAFQVILADRPCLELSADSEAEMADWMQHLCQAVSKGVIPQGIAPSP 897

  Fly  1135 TLGCTLIVTDNHLITLREDFSAPLRKISQQADNNAAVQGNKETMLEEDMLSVFETSSLMGSTIST 1199
            .:.|.|::|::.|.|..||...                            |.|.:
  Rat   898 CIPCCLVITEDRLFTCHEDCQT----------------------------SFFRS---------- 924

  Fly  1200 PTRGTQHSYSSLSSTPTKQTNEDAAPKETVASPEKSQRMTSVYGKNSGLAILTCADIKEMTGIKI 1264
                                                               |..|.:.::|.|..
  Rat   925 ---------------------------------------------------LGTARLADITAIST 938

  Fly  1265 TSRSETWWCILEFSCQEAPLENQDDLVIFFASSMEMQRFLRLLEQLWQSKNNDLFPITILDDGDS 1329
            ....|  :|:|||| |::| :.....||:.:.:.|:.|||..|...|::......|...:.:. |
  Rat   939 ELGKE--YCVLEFS-QDSP-QLPKPWVIYMSCTSELDRFLTALSSGWKAIYQVDLPHKAIHEA-S 998

  Fly  1330 LAEQYNKLYMDTNRAWE 1346
            :.:::.......:.||:
  Rat   999 IKQKFEDALSLIHSAWQ 1015

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
prd1	NP_650115.1	PH_SKIP	1022..1126	CDD:270119	32/106 (30%)
Plekhm2	NP_001178696.1	RUN_PLEKHM2	9..153	CDD:439042
		PHA03247	<409..572	CDD:223021	39/249 (16%)
		PH_SKIP	785..887	CDD:270119	32/106 (30%)