Protein Alignment prd1 and pkhm-2

DIOPT Version :10

• Sequence 1: NP_650115.1
• Gene: prd1 / 41425
• FlyBaseID: FBgn0037949
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_001408270.1
• Gene: pkhm-2 / 181612
• WormBaseID: WBGene00011680
• Length: 743
• Species: Caenorhabditis elegans
• Alignment Length: 804
• Identity: 135/804 - (16%)
• Similarity: 259/804 - (32%)
• Gaps: 275/804 - (34%)

  Fly   528 QHTSVASLLE-------QNTPIAEPAASQIKKSF--LDAPIAKTF---------SNFFRSFKDST 574
            ||....:|:|       :.|.|.:......:|.|  :|     ||         ..::|..:...
 Worm    19 QHGEFQNLVEGYVNKILRETDIVDAENPNGRKLFNSID-----TFFSYGLLTGDGTYWRCIRTFL 78

  Fly   575 PVAKDEQAVTDNYFASKIAKPQQQAPAAGKLQRNFSSSTISEPSSNTNTSSNHQIAMNPQLGNAE 639
            |.|:.:..:.:                .|.....|.|....:.|.|..|.....:|:|.|...|.
 Worm    79 PRAEQKMLIAE----------------CGNANDRFLSVGWLKTSFNKGTLHFILLALNNQSNKAY 127

  Fly   640 -RQSRHLPSPLKKRG---------QPLQPPRYYDQQHPHQSRSLHSPSAYLAAGRGGP-----GG 689
             .:..|:.:.::..|         :.|||.::..    :.:|.|.:..|..|.....|     ..
 Worm   128 LTKFYHINACIRNSGLLEAITQFIEKLQPVQFAF----YSTRQLRAEPAPAAVIDSTPTQLSLRA 188

  Fly   690 SGRDSKSTILSEEFDDILTITTTDTTN--ARSMDSDLVI------------VDYTDVDYAHLLKP 740
            ..|..|.|......|.:..:..|:..:  ::::|.|:::            .:..|..:....:.
 Worm   189 QARQRKLTEKEASQDTVPNVIPTEIPSILSQAIDQDVLLDELVRTRHNRLNTELFDAQHEENNED 253

  Fly   741 PAPAAKTSLINRFLRNVTQKKIMETSIRKNNFFADKLRTEQRHAGSDLYVKGARPKNYELIDDLN 805
            .||:... ::...|.:|..||:                       |.:.::...|...|
 Worm   254 NAPSPSV-IVEEKLEDVMTKKM-----------------------SCVNMESMNPDGIE------ 288

  Fly   806 AEIAMEIEMCGTNSPRRELAISLDNDFQGNLSNFELGIGEI---SIDVFKGKSLFNLKQSNEQLM 867
             .|...:|......|...||   |.::     :|.:..|::   :|:||        ::|:|:::
 Worm   289 -HILASVEPDDMVLPEYNLA---DGEY-----HFRMSQGDVLHLAINVF--------EKSSEKII 336

  Fly   868 KAFKLYTGYNVDGIMTPVLVLLTDKTLYV---------------VNMEGNSLCVK-FVLAYKDLD 916
            :.||:...::.|.:....|| :|:..:||               .|:......:. |.:.:..:.
 Worm   337 ECFKVIESFHSDNMKLRYLV-MTNYNVYVFKYRTHTQNSSPGKTTNLSSEGFFIPLFRMPHDRIK 400

  Fly   917 VILMGPFGNTVLLS-----------NSNRDMQQVLLAGGPYPAGSLVANLELCARRSGSTLPAVG 970
            .|.:.....:.:|.           :..:|.|.|....|.      :|.||     ||:
 Worm   401 TIKISVDNLSFMLEANEEGFSHYVHSEEKDDQTVFAYVGS------MAGLE-----SGA------ 448

  Fly   971 QLTLEHLAPLQAFVRANSCVGVAEHWMLYAVVNVPAGGSMRVESPSE---------LLGPSMKGF 1026
                 |:        .||.:.:.||            .|.::.:.:|         :|.|:::
 Worm   449 -----HM--------INSLINLVEH------------SSRQITNHAEVDDHIGYMCMLQPNLE-- 486

  Fly  1027 LMHRRLRQTISTSAANRIFWQPGYF-------LLKAGVLYMFNDSTQRLPSWAMALAECQG---- 1080
               ::|.:||...||...||....:       ..|:|.|:..|     :.:|..:..|.:.
 Worm   487 ---KQLGRTIDVRAATLCFWYEQTYEERERSTATKSGFLFKSN-----IGNWIKSSDEAEQKYCM 543

  Fly  1081 ---------ARRTVKSERPHCFEITLKGE--------VLQMAA---------PDEYVASEWLQAL 1119
                     |..|.|:|.   ..|:|.|.        ..||.|         |.:....||.:.|
 Worm   544 IVGNNFNVFADSTCKTEE---LVISLSGSSINSTGRVAFQMKAAEGTFEFECPTQEDQIEWTRIL 605

  Fly  1120 LQSASGLVVQEEKHKTLGCTLIVTDNHLITLRE-------DFSAPLRKIS----------QQADN 1167
            ...|.....|.   ....|..:||:..:..::|       .|...|.::.          :|.::
 Worm   606 TMIAENKTTQP---YMASCLAVVTETCIALVQEGEKFWSDGFLRLLNEVGGINVKQSVVVRQPED 667

  Fly  1168 NAAVQGNKETML----EEDMLSVF 1187
            ..:..||:...|    ::|.:..|
 Worm   668 KESFFGNRSPALCLVTKDDTIHYF 691

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
prd1	NP_650115.1	PH_SKIP	1022..1126	CDD:270119	28/140 (20%)
pkhm-2	NP_001408270.1	RUN_PLEKHM2	9..161	CDD:439042	29/162 (18%)