DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Elp1 and IKI3

DIOPT Version :9

Sequence 1:	NP_001262478.1	Gene:	Elp1 / 41399	FlyBaseID:	FBgn0037926	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_013488.3	Gene:	IKI3 / 851100	SGDID:	S000004376	Length:	1349	Species:	Saccharomyces cerevisiae

Alignment Length:	1305	Identity:	353/1305 - (27%)
Similarity:	584/1305 - (44%)	Gaps:	225/1305 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 YAVQESGDVRLKVI--ADLPDIVGVEFLQLDNAICVASGAGEVILVDP-QTGATSEGTFCDVGIE 105
            :.:|...|..|..:  ||:..:|.| |.|.|    :.:...:.:.:|| :|.....||. |.||.
Yeast    88 FNIQTFDDKLLSFVHFADINQLVFV-FEQGD----IITATYDPVSLDPAETLIEIMGTI-DNGIA 146

  Fly   106 SMAWSPNQEVVAFVTRTHNVVLMTSTFDVIAEQPLDAELDPDQQFVNVGWGKKETQFHGS----- 165
            :..||.::|.:|.||:..|||:::..|:.|:|..|:.:.....:.|.||||||||||.|.
Yeast   147 AAQWSYDEETLAMVTKDRNVVVLSKLFEPISEYHLEVDDLKISKHVTVGWGKKETQFRGKGARAM 211

  Fly   166 EGKQAAKQKES--------DST--FIRDEQELNQFTPQDVSISWRGDGEFFVVSYV--------- 211
            |.:..|..|.|        |.|  ::.|..::......:::||||||.::|.||.|
Yeast   212 EREALASLKASGLVGNQLRDPTMPYMVDTGDVTALDSHEITISWRGDCDYFAVSSVEEVPDEDDE 276

  Fly   212 -AAQLGRTFKVYDSEGKLNHTAEKSANLKDSVVWRPTGNWIAVPQQ-----FPNKSTIALFEKNG 270
             .:...|.|:|:..||:|:..:|....::..:.|:|.|:.||..|:     ..:...:..||:||
Yeast   277 TKSIKRRAFRVFSREGQLDSASEPVTGMEHQLSWKPQGSLIASIQRKTDLGEEDSVDVIFFERNG 341

  Fly   271 LRHREL--VLPFDLQEEPVVQLRWSEDSDILAIRTCAKEEQRVYLYTIGNYHWYLKQVLIFEQAD 333
            |||.|.  .||.|   |.|..:.|:.:|:.||:...    .|:.|:|..||||||||.|   .|.
Yeast   342 LRHGEFDTRLPLD---EKVESVCWNSNSEALAVVLA----NRIQLWTSKNYHWYLKQEL---YAS 396

  Fly   334 PLALLHWDTRCGAEHTLHVLKESGKHLVYRWAFAV---------DRNNSIVGVIDGKRLLLTDFD 389
            .::.:.|...  .:.|| :..::|...:..:|:.:         |...|:  |:||:.:.:|...
Yeast   397 DISYVKWHPE--KDFTL-MFSDAGFINIVDFAYKMAQGPTLEPFDNGTSL--VVDGRTVNITPLA 456

  Fly   390 EAIVPPPMSKIVLKFETYINAFISHGTSLWVYTC--DRKIY--LNEHIHTLG-----KELQK--- 442
            .|.|||||         |...|.:.|..|.| .|  ..:||  :|:.:....     :|::|
Yeast   457 LANVPPPM---------YYRDFETPGNVLDV-ACSFSNEIYAAINKDVLIFAAVPSIEEMKKGKH 511

  Fly   443 PIML--MPDAELSG-------------------LHLANLTHFSPHYLLATHSSAGSTRLLLLSYK 486
            |.::  .|.:|.:.                   |...||:..:   ||........|.:.::...
Yeast   512 PSIVCEFPKSEFTSEVDSLRQVAFINDSIVGVLLDTDNLSRIA---LLDIQDITQPTLITIVEVY 573

  Fly   487 D------NDNKPGEWFYRVHS----SVRINGLVNAVAVAPYAMNEFYVQTVNNGHTYEVSLKADK 541
            |      :|.......|....    .:...|.:..:...|..:.:|.|:.|:|     .|.:.|.
Yeast   574 DKIVLLRSDFDYNHLVYETRDGTVCQLDAEGQLMEITKFPQLVRDFRVKRVHN-----TSAEDDD 633

  Fly   542 TLKVERSYVQLHEPADQIDWVIVKGCIWDGYTGALVT--LRNQHLLHIDGYRIGEDVTSFCVVTN 604
            .                          |...:..||.  :.|...|..:...:...|||..:..:
Yeast   634 N--------------------------WSAESSELVAFGITNNGKLFANQVLLASAVTSLEITDS 672

  Fly   605 YLVYT---------QLNAMHFVQL-------DDRRQVASRNIERGAKIVTAVARKARVVLQLPRG 653
            :|::|         .||:..|..|       :|.|   .|.||||:.:|:.:..|:.||||..||
Yeast   673 FLLFTTAQHNLQFVHLNSTDFKPLPLVEEGVEDER---VRAIERGSILVSVIPSKSSVVLQATRG 734

  Fly   654 NLEAICPRVLVLELVGDLLERGKYQKAIEMSRKQRINLNIIFDHDVKRFVSSVGAFLNDINEPQW 718
            |||.|.||::||..|...:...:|::|..:.|..||||:|:.|:..:.|:.::..|:|.|....:
Yeast   735 NLETIYPRIMVLAEVRKNIMAKRYKEAFIVCRTHRINLDILHDYAPELFIENLEVFINQIGRVDY 799

  Fly   719 LCLFLSELQNEDFTKGMYSSN-YDA-SK------------QTYPSDYRVDQKVEYVCRLLEQQMN 769
            |.||:|.|..:|.||..|... |.. ||            |.|......|.|...|.::.:..:|
Yeast   800 LNLFISCLSEDDVTKTKYKETLYSGISKSFGMEPAPLTEMQIYMKKKMFDPKTSKVNKICDAVLN 864

  Fly   770 RFVS------RFRLPLITAYVKLG--CLEMALQVIWKEQQEDASLADQLLQHLLYLVDVNDLYNV 826
            ..:|      ::...:||||....  .|..||::|  .:.|::...|..:.:|.:|.|||.:|..
Yeast   865 VLLSNPEYKKKYLQTIITAYASQNPQNLSAALKLI--SELENSEEKDSCVTYLCFLQDVNVVYKS 927

  Fly   827 ALGTYDFGLVLFVAQKSQKDPKEFLPYLNDLKALPIDYRKFRIDDHLKRYTSALSHLAACGEQH- 890
            ||..||..|.|.||||||.||:|:||:|.:|:......|||.|||:|..|..||.||:...:..
Yeast   928 ALSLYDVSLALLVAQKSQMDPREYLPFLQELQDNEPLRRKFLIDDYLGNYEKALEHLSEIDKDGN 992

  Fly   891 -YEEALEYIRKHGLYTDGLAFYREHIEFQKNIYVAYADHLRAIAKLDNASLMYERGGQLQQALLS 954
             .||.::|:..|.||..|||.||...|.|..||..||.||.:.....:|::.||..|:|::|:.:
Yeast   993 VSEEVIDYVESHDLYKHGLALYRYDSEKQNVIYNIYAKHLSSNQMYTDAAVAYEMLGKLKEAMGA 1057

  Fly   955 AKHTLDWQRVLVLA-KKLSEPLDQVAQSLVGPLQQQGRHMEAYELVKEHCQDRKRQFDVLLEGHL 1018
            .:....|:..:.:| :|..|.::.||:.|:..|..:.|:::|.::..|:..:.|....:..:.:.
Yeast  1058 YQSAKRWREAMSIAVQKFPEEVESVAEELISSLTFEHRYVDAADIQLEYLDNVKEAVALYCKAYR 1122

  Fly  1019 YSRA-IYEAGLEDDDVSEKIAPALLAYGVQLESSLQADLQLFLDYKQRLLDIRRNQAKSGEG-YI 1081
            |..| :.....:.|::.|::....|..|..:.:.|.||.:..::.:.|.|  |..:||..|. |.
Yeast  1123 YDIASLVAIKAKKDELLEEVVDPGLGEGFGIIAELLADCKGQINSQLRRL--RELRAKKEENPYA 1185

  Fly  1082 DTDVNLKEVDLLSDTTSLHSSQYSGTSRRTGKT---------FRSSKNRRKHERKLFSLKPGNPF 1137
            ......::.|.:|...|..|:|.|..:|.||||         .|::||:|:.|||....|.|..:
Yeast  1186 FYGQETEQADDVSVAPSETSTQESFFTRYTGKTGGTAKTGASRRTAKNKRREERKRARGKKGTIY 1250

  Fly  1138 EDIALIDALHNHVTKIAQQQ----QPVRDTCKALLQLANAADADPLAAALQREFKTLLQAVDAAL 1198
            |:..|:.::...:.::.|.:    :.|...|:..::        ..|..:|:.|..:|..:.|.:
Yeast  1251 EEEYLVQSVGRLIERLNQTKPDAVRVVEGLCRRNMR--------EQAHQIQKNFVEVLDLLKANV 1307

  Fly  1199 DEIWT 1203
            .||::
Yeast  1308 KEIYS 1312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Elp1	NP_001262478.1	IKI3	1..887	CDD:282600	268/969 (28%)
Elp1	NP_001262478.1	COG5290	13..1207	CDD:227610	353/1305 (27%)
IKI3	NP_013488.3	COG5290	18..1348	CDD:227610	353/1305 (27%)
		TPR repeat	1004..1034	CDD:276809	16/29 (55%)
		TPR repeat	1039..1063	CDD:276809	6/23 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345387
Domainoid	1	1.000	283	1.000	Domainoid score	I253
eggNOG	1	0.900	-	-		E1_COG5290
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2699
Inparanoid	1	1.050	370	1.000	Inparanoid score	I359
Isobase	1	0.950	-	0.993157	Normalized mean entropy	S3846
OMA	1	1.010	-	-		QHG55001
OrthoFinder	1	1.000	-	-		FOG0005043
OrthoInspector	1	1.000	-	-		oto99746
orthoMCL	1	0.900	-	-		OOG6_102646
Panther	1	1.100	-	-	LDO	PTHR12747
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R390
SonicParanoid	1	1.000	-	-		X3567
TreeFam	1	0.960	-	-
	16	15.740