Protein Alignment Elp1 and IKI3

DIOPT Version :10

• Sequence 1: NP_001262478.1
• Gene: Elp1 / 41399
• FlyBaseID: FBgn0037926
• Length: 1256
• Species: Drosophila melanogaster
• Sequence 2: NP_013488.3
• Gene: IKI3 / 851100
• SGDID: S000004376
• Length: 1349
• Species: Saccharomyces cerevisiae
• Alignment Length: 1305
• Identity: 353/1305 - (27%)
• Similarity: 584/1305 - (44%)
• Gaps: 225/1305 - (17%)

  Fly    44 YAVQESGDVRLKVI--ADLPDIVGVEFLQLDNAICVASGAGEVILVDP-QTGATSEGTFCDVGIE 105
            :.:|...|..|..:  ||:..:|.| |.|.|    :.:...:.:.:|| :|.....||. |.||.
Yeast    88 FNIQTFDDKLLSFVHFADINQLVFV-FEQGD----IITATYDPVSLDPAETLIEIMGTI-DNGIA 146

  Fly   106 SMAWSPNQEVVAFVTRTHNVVLMTSTFDVIAEQPLDAELDPDQQFVNVGWGKKETQFHGS----- 165
            :..||.::|.:|.||:..|||:::..|:.|:|..|:.:.....:.|.||||||||||.|.
Yeast   147 AAQWSYDEETLAMVTKDRNVVVLSKLFEPISEYHLEVDDLKISKHVTVGWGKKETQFRGKGARAM 211

  Fly   166 EGKQAAKQKES--------DST--FIRDEQELNQFTPQDVSISWRGDGEFFVVSYV--------- 211
            |.:..|..|.|        |.|  ::.|..::......:::||||||.::|.||.|
Yeast   212 EREALASLKASGLVGNQLRDPTMPYMVDTGDVTALDSHEITISWRGDCDYFAVSSVEEVPDEDDE 276

  Fly   212 -AAQLGRTFKVYDSEGKLNHTAEKSANLKDSVVWRPTGNWIAVPQQ-----FPNKSTIALFEKNG 270
             .:...|.|:|:..||:|:..:|....::..:.|:|.|:.||..|:     ..:...:..||:||
Yeast   277 TKSIKRRAFRVFSREGQLDSASEPVTGMEHQLSWKPQGSLIASIQRKTDLGEEDSVDVIFFERNG 341

  Fly   271 LRHREL--VLPFDLQEEPVVQLRWSEDSDILAIRTCAKEEQRVYLYTIGNYHWYLKQVLIFEQAD 333
            |||.|.  .||.|   |.|..:.|:.:|:.||:...    .|:.|:|..||||||||.|   .|.
Yeast   342 LRHGEFDTRLPLD---EKVESVCWNSNSEALAVVLA----NRIQLWTSKNYHWYLKQEL---YAS 396

  Fly   334 PLALLHWDTRCGAEHTLHVLKESGKHLVYRWAFAV---------DRNNSIVGVIDGKRLLLTDFD 389
            .::.:.|...  .:.|| :..::|...:..:|:.:         |...|:  |:||:.:.:|...
Yeast   397 DISYVKWHPE--KDFTL-MFSDAGFINIVDFAYKMAQGPTLEPFDNGTSL--VVDGRTVNITPLA 456

  Fly   390 EAIVPPPMSKIVLKFETYINAFISHGTSLWVYTC--DRKIY--LNEHIHTLG-----KELQK--- 442
            .|.|||||         |...|.:.|..|.| .|  ..:||  :|:.:....     :|::|
Yeast   457 LANVPPPM---------YYRDFETPGNVLDV-ACSFSNEIYAAINKDVLIFAAVPSIEEMKKGKH 511

  Fly   443 PIML--MPDAELSG-------------------LHLANLTHFSPHYLLATHSSAGSTRLLLLSYK 486
            |.::  .|.:|.:.                   |...||:..:   ||........|.:.::...
Yeast   512 PSIVCEFPKSEFTSEVDSLRQVAFINDSIVGVLLDTDNLSRIA---LLDIQDITQPTLITIVEVY 573

  Fly   487 D------NDNKPGEWFYRVHS----SVRINGLVNAVAVAPYAMNEFYVQTVNNGHTYEVSLKADK 541
            |      :|.......|....    .:...|.:..:...|..:.:|.|:.|:|     .|.:.|.
Yeast   574 DKIVLLRSDFDYNHLVYETRDGTVCQLDAEGQLMEITKFPQLVRDFRVKRVHN-----TSAEDDD 633

  Fly   542 TLKVERSYVQLHEPADQIDWVIVKGCIWDGYTGALVT--LRNQHLLHIDGYRIGEDVTSFCVVTN 604
            .                          |...:..||.  :.|...|..:...:...|||..:..:
Yeast   634 N--------------------------WSAESSELVAFGITNNGKLFANQVLLASAVTSLEITDS 672

  Fly   605 YLVYT---------QLNAMHFVQL-------DDRRQVASRNIERGAKIVTAVARKARVVLQLPRG 653
            :|::|         .||:..|..|       :|.|   .|.||||:.:|:.:..|:.||||..||
Yeast   673 FLLFTTAQHNLQFVHLNSTDFKPLPLVEEGVEDER---VRAIERGSILVSVIPSKSSVVLQATRG 734

  Fly   654 NLEAICPRVLVLELVGDLLERGKYQKAIEMSRKQRINLNIIFDHDVKRFVSSVGAFLNDINEPQW 718
            |||.|.||::||..|...:...:|::|..:.|..||||:|:.|:..:.|:.::..|:|.|....:
Yeast   735 NLETIYPRIMVLAEVRKNIMAKRYKEAFIVCRTHRINLDILHDYAPELFIENLEVFINQIGRVDY 799

  Fly   719 LCLFLSELQNEDFTKGMYSSN-YDA-SK------------QTYPSDYRVDQKVEYVCRLLEQQMN 769
            |.||:|.|..:|.||..|... |.. ||            |.|......|.|...|.::.:..:|
Yeast   800 LNLFISCLSEDDVTKTKYKETLYSGISKSFGMEPAPLTEMQIYMKKKMFDPKTSKVNKICDAVLN 864

  Fly   770 RFVS------RFRLPLITAYVKLG--CLEMALQVIWKEQQEDASLADQLLQHLLYLVDVNDLYNV 826
            ..:|      ::...:||||....  .|..||::|  .:.|::...|..:.:|.:|.|||.:|..
Yeast   865 VLLSNPEYKKKYLQTIITAYASQNPQNLSAALKLI--SELENSEEKDSCVTYLCFLQDVNVVYKS 927

  Fly   827 ALGTYDFGLVLFVAQKSQKDPKEFLPYLNDLKALPIDYRKFRIDDHLKRYTSALSHLAACGEQH- 890
            ||..||..|.|.||||||.||:|:||:|.:|:......|||.|||:|..|..||.||:...:..
Yeast   928 ALSLYDVSLALLVAQKSQMDPREYLPFLQELQDNEPLRRKFLIDDYLGNYEKALEHLSEIDKDGN 992

  Fly   891 -YEEALEYIRKHGLYTDGLAFYREHIEFQKNIYVAYADHLRAIAKLDNASLMYERGGQLQQALLS 954
             .||.::|:..|.||..|||.||...|.|..||..||.||.:.....:|::.||..|:|::|:.:
Yeast   993 VSEEVIDYVESHDLYKHGLALYRYDSEKQNVIYNIYAKHLSSNQMYTDAAVAYEMLGKLKEAMGA 1057

  Fly   955 AKHTLDWQRVLVLA-KKLSEPLDQVAQSLVGPLQQQGRHMEAYELVKEHCQDRKRQFDVLLEGHL 1018
            .:....|:..:.:| :|..|.::.||:.|:..|..:.|:::|.::..|:..:.|....:..:.:.
Yeast  1058 YQSAKRWREAMSIAVQKFPEEVESVAEELISSLTFEHRYVDAADIQLEYLDNVKEAVALYCKAYR 1122

  Fly  1019 YSRA-IYEAGLEDDDVSEKIAPALLAYGVQLESSLQADLQLFLDYKQRLLDIRRNQAKSGEG-YI 1081
            |..| :.....:.|::.|::....|..|..:.:.|.||.:..::.:.|.|  |..:||..|. |.
Yeast  1123 YDIASLVAIKAKKDELLEEVVDPGLGEGFGIIAELLADCKGQINSQLRRL--RELRAKKEENPYA 1185

  Fly  1082 DTDVNLKEVDLLSDTTSLHSSQYSGTSRRTGKT---------FRSSKNRRKHERKLFSLKPGNPF 1137
            ......::.|.:|...|..|:|.|..:|.||||         .|::||:|:.|||....|.|..:
Yeast  1186 FYGQETEQADDVSVAPSETSTQESFFTRYTGKTGGTAKTGASRRTAKNKRREERKRARGKKGTIY 1250

  Fly  1138 EDIALIDALHNHVTKIAQQQ----QPVRDTCKALLQLANAADADPLAAALQREFKTLLQAVDAAL 1198
            |:..|:.::...:.::.|.:    :.|...|:..::        ..|..:|:.|..:|..:.|.:
Yeast  1251 EEEYLVQSVGRLIERLNQTKPDAVRVVEGLCRRNMR--------EQAHQIQKNFVEVLDLLKANV 1307

  Fly  1199 DEIWT 1203
            .||::
Yeast  1308 KEIYS 1312

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Elp1	NP_001262478.1	IKI3	1..887	CDD:428111	268/969 (28%)
IKI3	NP_013488.3	COG5290	18..1348	CDD:227610	353/1305 (27%)
		TPR repeat	1004..1034	CDD:276809	16/29 (55%)
		TPR repeat	1039..1063	CDD:276809	6/23 (26%)