Protein Alignment: Elp1 and IKI3

• Sequence 1: NP_001262478.1
• Gene: Elp1
• FlyBaseID: FBgn0037926
• Length: 1256
• Species: Drosophila melanogaster
• Sequence 2: NP_013488.3
• Gene: IKI3
• SGDID: S000004376
• Length: 1349
• Species: Saccharomyces cerevisiae
• Alignment Length: 1305
• Identity: 353/1306 (27%)
• Similarity: 584/1306 (45%)
• Gaps: 225/1306 (17%)

  Fly    44 YAVQESGDVRLKVI--ADLPDIVGVEFLQLDNAICVASGAGEVILVDP-QTGATSEGTFCDVGIE 105
            :.:|...|..|..:  ||:..:|.| |.|.|    :.:...:.:.:|| :|.....||. |.||.
Yeast    88 FNIQTFDDKLLSFVHFADINQLVFV-FEQGD----IITATYDPVSLDPAETLIEIMGTI-DNGIA 146

  Fly   106 SMAWSPNQEVVAFVTRTHNVVLMTSTFDVIAEQPLDAELDPDQQFVNVGWGKKETQFHGS----- 165
            :..||.::|.:|.||:..|||:::..|:.|:|..|:.:.....:.|.||||||||||.|.
Yeast   147 AAQWSYDEETLAMVTKDRNVVVLSKLFEPISEYHLEVDDLKISKHVTVGWGKKETQFRGKGARAM 211

  Fly   166 EGKQAAKQKES--------DST--FIRDEQELNQFTPQDVSISWRGDGEFFVVSYV--------- 211
            |.:..|..|.|        |.|  ::.|..::......:::||||||.::|.||.|
Yeast   212 EREALASLKASGLVGNQLRDPTMPYMVDTGDVTALDSHEITISWRGDCDYFAVSSVEEVPDEDDE 276

  Fly   212 -AAQLGRTFKVYDSEGKLNHTAEKSANLKDSVVWRPTGNWIAVPQQ-----FPNKSTIALFEKNG 270
             .:...|.|:|:..||:|:..:|....::..:.|:|.|:.||..|:     ..:...:..||:||
Yeast   277 TKSIKRRAFRVFSREGQLDSASEPVTGMEHQLSWKPQGSLIASIQRKTDLGEEDSVDVIFFERNG 341

  Fly   271 LRHREL--VLPFDLQEEPVVQLRWSEDSDILAIRTCAKEEQRVYLYTIGNYHWYLKQVLIFEQAD 333
            |||.|.  .||.|   |.|..:.|:.:|:.||:...    .|:.|:|..||||||||.|   .|.
Yeast   342 LRHGEFDTRLPLD---EKVESVCWNSNSEALAVVLA----NRIQLWTSKNYHWYLKQEL---YAS 396

  Fly   334 PLALLHWDTRCGAEHTLHVLKESGKHLVYRWAFAV---------DRNNSIVGVIDGKRLLLTDFD 389
            .::.:.|...  .:.|| :..::|...:..:|:.:         |...|:  |:||:.:.:|...
Yeast   397 DISYVKWHPE--KDFTL-MFSDAGFINIVDFAYKMAQGPTLEPFDNGTSL--VVDGRTVNITPLA 456

  Fly   390 EAIVPPPMSKIVLKFETYINAFISHGTSLWVYTC--DRKIY--LNEHIHTLG-----KELQK--- 442
            .|.|||||         |...|.:.|..|.| .|  ..:||  :|:.:....     :|::|
Yeast   457 LANVPPPM---------YYRDFETPGNVLDV-ACSFSNEIYAAINKDVLIFAAVPSIEEMKKGKH 511

  Fly   443 PIML--MPDAELSG-------------------LHLANLTHFSPHYLLATHSSAGSTRLLLLSYK 486
            |.::  .|.:|.:.                   |...||:..:   ||........|.:.::...
Yeast   512 PSIVCEFPKSEFTSEVDSLRQVAFINDSIVGVLLDTDNLSRIA---LLDIQDITQPTLITIVEVY 573

  Fly   487 D------NDNKPGEWFYRVHS----SVRINGLVNAVAVAPYAMNEFYVQTVNNGHTYEVSLKADK 541
            |      :|.......|....    .:...|.:..:...|..:.:|.|:.|:|     .|.:.|.
Yeast   574 DKIVLLRSDFDYNHLVYETRDGTVCQLDAEGQLMEITKFPQLVRDFRVKRVHN-----TSAEDDD 633

  Fly   542 TLKVERSYVQLHEPADQIDWVIVKGCIWDGYTGALVT--LRNQHLLHIDGYRIGEDVTSFCVVTN 604
            .                          |...:..||.  :.|...|..:...:...|||..:..:
Yeast   634 N--------------------------WSAESSELVAFGITNNGKLFANQVLLASAVTSLEITDS 672

  Fly   605 YLVYT---------QLNAMHFVQL-------DDRRQVASRNIERGAKIVTAVARKARVVLQLPRG 653
            :|::|         .||:..|..|       :|.|   .|.||||:.:|:.:..|:.||||..||
Yeast   673 FLLFTTAQHNLQFVHLNSTDFKPLPLVEEGVEDER---VRAIERGSILVSVIPSKSSVVLQATRG 734

  Fly   654 NLEAICPRVLVLELVGDLLERGKYQKAIEMSRKQRINLNIIFDHDVKRFVSSVGAFLNDINEPQW 718
            |||.|.||::||..|...:...:|::|..:.|..||||:|:.|:..:.|:.::..|:|.|....:
Yeast   735 NLETIYPRIMVLAEVRKNIMAKRYKEAFIVCRTHRINLDILHDYAPELFIENLEVFINQIGRVDY 799

  Fly   719 LCLFLSELQNEDFTKGMYSSN-YDA-SK------------QTYPSDYRVDQKVEYVCRLLEQQMN 769
            |.||:|.|..:|.||..|... |.. ||            |.|......|.|...|.::.:..:|
Yeast   800 LNLFISCLSEDDVTKTKYKETLYSGISKSFGMEPAPLTEMQIYMKKKMFDPKTSKVNKICDAVLN 864

  Fly   770 RFVS------RFRLPLITAYVKLG--CLEMALQVIWKEQQEDASLADQLLQHLLYLVDVNDLYNV 826
            ..:|      ::...:||||....  .|..||::|  .:.|::...|..:.:|.:|.|||.:|..
Yeast   865 VLLSNPEYKKKYLQTIITAYASQNPQNLSAALKLI--SELENSEEKDSCVTYLCFLQDVNVVYKS 927

  Fly   827 ALGTYDFGLVLFVAQKSQKDPKEFLPYLNDLKALPIDYRKFRIDDHLKRYTSALSHLAACGEQH- 890
            ||..||..|.|.||||||.||:|:||:|.:|:......|||.|||:|..|..||.||:...:..
Yeast   928 ALSLYDVSLALLVAQKSQMDPREYLPFLQELQDNEPLRRKFLIDDYLGNYEKALEHLSEIDKDGN 992

  Fly   891 -YEEALEYIRKHGLYTDGLAFYREHIEFQKNIYVAYADHLRAIAKLDNASLMYERGGQLQQALLS 954
             .||.::|:..|.||..|||.||...|.|..||..||.||.:.....:|::.||..|:|::|:.:
Yeast   993 VSEEVIDYVESHDLYKHGLALYRYDSEKQNVIYNIYAKHLSSNQMYTDAAVAYEMLGKLKEAMGA 1057

  Fly   955 AKHTLDWQRVLVLA-KKLSEPLDQVAQSLVGPLQQQGRHMEAYELVKEHCQDRKRQFDVLLEGHL 1018
            .:....|:..:.:| :|..|.::.||:.|:..|..:.|:::|.::..|:..:.|....:..:.:.
Yeast  1058 YQSAKRWREAMSIAVQKFPEEVESVAEELISSLTFEHRYVDAADIQLEYLDNVKEAVALYCKAYR 1122

  Fly  1019 YSRA-IYEAGLEDDDVSEKIAPALLAYGVQLESSLQADLQLFLDYKQRLLDIRRNQAKSGEG-YI 1081
            |..| :.....:.|::.|::....|..|..:.:.|.||.:..::.:.|.|  |..:||..|. |.
Yeast  1123 YDIASLVAIKAKKDELLEEVVDPGLGEGFGIIAELLADCKGQINSQLRRL--RELRAKKEENPYA 1185

  Fly  1082 DTDVNLKEVDLLSDTTSLHSSQYSGTSRRTGKT---------FRSSKNRRKHERKLFSLKPGNPF 1137
            ......::.|.:|...|..|:|.|..:|.||||         .|::||:|:.|||....|.|..:
Yeast  1186 FYGQETEQADDVSVAPSETSTQESFFTRYTGKTGGTAKTGASRRTAKNKRREERKRARGKKGTIY 1250

  Fly  1138 EDIALIDALHNHVTKIAQQQ----QPVRDTCKALLQLANAADADPLAAALQREFKTLLQAVDAAL 1198
            |:..|:.::...:.::.|.:    :.|...|:..::        ..|..:|:.|..:|..:.|.:
Yeast  1251 EEEYLVQSVGRLIERLNQTKPDAVRVVEGLCRRNMR--------EQAHQIQKNFVEVLDLLKANV 1307

  Fly  1199 DEIWT 1203
            .||::
Yeast  1308 KEIYS 1312

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Elp1	NP_001262478.1	IKI3	1..887	CDD:282600	268/970 (28%)
		COG5290	13..1207	CDD:227610	353/1306 (27%)
IKI3	NP_013488.3	COG5290	18..1348	CDD:227610	353/1306 (27%)
		IKI3	18..988	CDD:282600	268/970 (28%)
		WD40 repeat	308..352	CDD:293791	15/44 (34%)
		WD40 repeat	357..390	CDD:293791	14/37 (38%)
		WD40 repeat	398..424	CDD:293791	4/29 (14%)
		TPR repeat	1004..1034	CDD:276809	16/30 (53%)
		TPR repeat	1039..1063	CDD:276809	6/24 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C341818368
eggNOG	1	0.900				E1_COG5290
Hieranoid	1	1.000
Homologene	1	1.000				H2699
Inparanoid	1	1.050	370	1.000	Inparanoid score	I354
Isobase	1	0.950		0.993157	Normalized mean entropy	S3846
OMA	1	1.010
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000				FOG0003022
OrthoInspector	1	1.000				T1136350
orthoMCL	1	0.900				OOG5_129360
Panther	1	1.100			LDO	PTHR12747
Phylome	1	0.910		0.667	Consistency score
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R390
TreeFam	1	0.960
	14	13.740