DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Elp1 and Elp1

DIOPT Version :9

Sequence 1:	NP_001262478.1	Gene:	Elp1 / 41399	FlyBaseID:	FBgn0037926	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_543175.2	Gene:	Elp1 / 140934	RGDID:	620072	Length:	1331	Species:	Rattus norvegicus

Alignment Length:	1391	Identity:	433/1391 - (31%)
Similarity:	692/1391 - (49%)	Gaps:	195/1391 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRNLKLRYC---KELNAVAHPQHLLLQPE----LNGGASDIYFVVADNKIYAVQESGDVRLKVIA 58
            ||||||...   :::.|...||...|:.|    |.|....:      .::..|::.....:.::|
  Rat     1 MRNLKLHQTLEFRDIQAPGKPQCFCLRAEQGTVLIGSERGL------TEVDPVKKEVKTEISLVA 59

  Fly    59 D--LPD-----IVGVEFLQLDNAICVASGAGEVILVDPQT------GATSEGTFCDVGIESMAWS 110
            :  ||:     |||::.|....::|||:.:|:||:.:..|      |..:.      ||..|:||
  Rat    60 EGFLPEDGSGCIVGIQDLLDQESVCVATASGDVIVCNVSTQQLECVGNVAS------GISVMSWS 118

  Fly   111 PNQEVVAFVTRTHNVVLMTSTFDVIAEQPLDAELDPDQQFVNVGWGKKETQFHGSEGKQ---AAK 172
            |:||::...|....:::||..::||.||.:..:...:.:|:.||||.|:||||||||:.   ..:
  Rat   119 PDQELLLLATAQQTLIMMTRDYEVITEQQIHQDDFGEGKFITVGWGSKDTQFHGSEGRPITFPVQ 183

  Fly   173 QKESDSTFIRDEQELNQFTPQDVSISWRGDGEFFVVSYVAAQLG-RTFKVYDSEGKLNHTAEKSA 236
            ..||..::       :...||   |:|||||:||.||.|.:|.| |..:|::.|..|..|:|...
  Rat   184 MHESALSW-------DDHRPQ---ITWRGDGQFFAVSVVCSQTGARKIRVWNREFALQSTSESVP 238

  Fly   237 NLKDSVVWRPTGNWIAVPQQFPNKSTIALFEKNGLRHRELVLPFDLQEEPVVQLRWSEDSDILAI 301
            .|..|:.|:|:|:.||..|..||:..:..||||||.|....|||...|..|..|.|:.||.:||:
  Rat   239 GLGPSLAWKPSGSLIASTQDKPNQQDVVFFEKNGLLHGYFTLPFLKDEVKVNDLLWNADSSVLAV 303

  Fly   302 --RTCAKE-----EQRVYLYTIGNYHWYLKQVLIFEQA--DPLALLHWDTRCGAEHTLHVLKESG 357
              ....||     :..|.|:|:|||||||||.|.|...  :.:..|.||......  ||||.:..
  Rat   304 WLEDLPKEGSSTLKSYVQLWTVGNYHWYLKQSLPFSTTGKNQIVSLLWDPVTPGR--LHVLCQGW 366

  Fly   358 KHLVYRWAFAVDRN--NSI-----VGVIDGKRLLLTDFDEAIVPPPMSKIVLKFETYIN------ 409
            ::|...|.:..||:  ||.     |.||||.::|:|.|...:.||||....|.....:|
  Rat   367 RYLCCDWHWTTDRSSGNSADDLANVAVIDGNKVLVTVFQRTVTPPPMCTYRLLIPHPVNQVMFSA 431

  Fly   410 ------AFISHGTSLWVYTCDRKIYLNEHIHTLG-------------KELQKPIMLM-----PDA 450
                  |.:.....:.||.||.|..::..: .||             ..|:|...:.     .:.
  Rat   432 HLGNDLAVLDASNQISVYKCDDKPDMDSTV-KLGAVGGTGFKVPLRTPHLEKRYRIQFGNKEEEE 495

  Fly   451 ELSGLHLANLTHFSPHYLLA---THSSAGS-TRLLLLSYKDNDNKPGEWFYRVHSSVRINGLV-- 509
            ::|.|....||.......||   :|||..| ...|.::..:.|.:.|:  ..|.|||.::|:|
  Rat   496 DVSPLQFRFLTWIEGDAFLAISHSHSSPQSIIHHLTMAGSEGDEEQGQ--LNVSSSVTVDGVVIG 558

  Fly   510 ---------NAVAVAPYAMNEFYVQTVNNGHTYEVSLKADKTLKVERSYVQLHEPADQIDWVIVK 565
                     :||.:|...:.::..::.::.        .:.....|...|:...|..|::...:.
  Rat   559 LCCCSKTKSSAVQLADGQVLKYLWESPSSA--------VEPWKNSEGRPVRFARPCTQMEAAAIG 615

  Fly   566 G--CIWDGYTGALVTLRNQHLLHIDGYRIGEDVTSFCVVTNYLVYT---------QLNAMHFVQL 619
            |  |:        :.|.::....|:...:..::|||.|..::|:.|         .|:......|
  Rat   616 GEECV--------LGLTDRCRFFINDTEVASNITSFAVCDDFLLVTTHSHTCQCFSLSGASLKML 672

  Fly   620 DD---RRQVAS----RNIERGAKIVTAVARKARVVLQLPRGNLEAICPRVLVLELVGDLLERGKY 677
            ..   ..||.|    |.:|||::|||.|.:..:::||:||||||.:..|.|||..:...|::..:
  Rat   673 QAGLCGSQVPSGEILRKVERGSRIVTVVPQDTKLILQMPRGNLEVVHHRALVLAQIRKWLDKLMF 737

  Fly   678 QKAIEMSRKQRINLNIIFDHDVKRFVSSVGAFLNDINEPQWLCLFLSELQNEDFTKGMYSSNYDA 742
            ::|.|..||.|||||:|.||:.|.|:.:|..|:..|:....|.||.:||:.||.||.||......
  Rat   738 KEAFECMRKLRINLNLIHDHNPKVFLENVETFIKQIDSVNHLNLFFTELKEEDVTKTMYPPPVTK 802

  Fly   743 SKQ--TYPSDYRVDQKVEYVCRLLEQQMNRFVSR-FRLPLITAYVKLGC--LEMALQVIWKEQ-- 800
            |.|  |.|.    .:||:.:|..:...|.....| |.|.::|::||...  |::.||.:.:.|
  Rat   803 SVQVSTNPD----GKKVDLICDAMRVAMETINPRKFCLSILTSHVKKTTPELDIVLQKVHELQGK 863

  Fly   801 ---QEDASLADQLLQHLLYLVDVNDLYNVALGTYDFGLVLFVAQKSQKDPKEFLPYLNDLKALPI 862
               :.::..|::.|::||.|||||:|:|.:||||||.|||.||:||||||||:||:||.||.:..
  Rat   864 IPFEPESVSAEEALKYLLLLVDVNELFNHSLGTYDFDLVLMVAEKSQKDPKEYLPFLNTLKKMET 928

  Fly   863 DYRKFRIDDHLKRYTSALSHLAACGEQHYEEALEYIRKHGLYTDGLAFYREHIEFQKNIYVAYAD 927
            :|::|.||.:||||..||.||:.||.:::.|.|..|:...||.:.|..||......:.:.|||.:
  Rat   929 NYQRFTIDKYLKRYEKALGHLSKCGPEYFTECLNLIKDKNLYKEALKLYRPDSPQYQAVSVAYGE 993

  Fly   928 HLRAIAKLDNASLMYERGGQLQQALLSAKHTLDWQRVLVLAKKLSEPLDQV---AQSLVGPLQQQ 989
            ||......:.|.|::.|.|..::||.:......||:.|.:|.:|....|:|   |::|.|.|.:|
  Rat   994 HLVQEHLYEPAGLVFARCGAHEKALEAFLACGSWQQALCMAAQLQMAKDKVAGLARTLAGKLVEQ 1058

  Fly   990 GRHMEAYELVKEHCQDRKRQFDVLLEGHLYSRAIYEAGLED--DDVSEKIAPALLAYGVQLESSL 1052
            .:|.||..:::::.||.:....:||||..:..|:......|  |.:...:.|::|.........|
  Rat  1059 RKHSEAATVLEQYAQDYEEAVLLLLEGSAWEEALRLVYKYDRVDIIETSVKPSILEAQKNYMDFL 1123

  Fly  1053 QADLQLFLDYKQRLLDIRRNQAKSGEGYIDTDV-NLKEVDLLSDTTSLH-----SSQYSGTSRRT 1111
            .:....|:.:|.||..:|..::::...::|.:| :.:|.||.|:|:|:.     |.:||.::.|.
  Rat  1124 DSQTATFIRHKNRLKVVRELKSQAPRVHVDHEVAHGRETDLFSETSSIRSGSEMSGRYSHSNSRI 1188

  Fly  1112 GKTFRSSKNRRKHERKLFSLKPGNPFEDIALIDALHNHVTKIAQQQQPVRDTCKALLQLANAADA 1176
              :.||||||||.|||..|||.|:|.|.:||::||    :::.|..:.::|...|:|::....:.
  Rat  1189 --SARSSKNRRKAERKKHSLKEGSPLEGLALLEAL----SEVVQSIEKLKDEVHAILKVLFLFEF 1247

  Fly  1177 DPLAAALQREFKTLLQAVDAALDEIWTPELRGNGLMADHLTGPNV---DYLALQKEQR------- 1231
            :..|..|||.|::.||.:..||.:|||  |.|....|..:.||:.   ..:|..::|:
  Rat  1248 EEQARELQRAFESTLQLMGTALPDIWT--LTGQQSSATPVLGPSSTVNSIMASYQQQKTCVPVLD 1310

  Fly  1232 -YALLSPLKRFKPQLIMMDWQHEILQ 1256
             :|.|.|....:.|     |:..:|:
  Rat  1311 AWACLPPKIDQRSQ-----WKLSLLE 1331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Elp1	NP_001262478.1	IKI3	1..887	CDD:282600	318/998 (32%)
Elp1	NP_001262478.1	COG5290	13..1207	CDD:227610	414/1314 (32%)
Elp1	NP_543175.2	IKI3	1..953	CDD:398435	338/1064 (32%)
		WD40 repeat	112..147	CDD:293791	9/34 (26%)
		WD40 repeat	198..231	CDD:293791	16/33 (48%)
		TPR	874..1099	CDD:223533	67/230 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1167..1207		13/39 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349537
Domainoid	1	1.000	406	1.000	Domainoid score	I696
eggNOG	1	0.900	-	-		E1_COG5290
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2699
Inparanoid	1	1.050	544	1.000	Inparanoid score	I1118
OMA	1	1.010	-	-		QHG55001
OrthoDB	1	1.010	-	-		D112285at33208
OrthoFinder	1	1.000	-	-		FOG0005043
OrthoInspector	1	1.000	-	-		oto97397
orthoMCL	1	0.900	-	-		OOG6_102646
Panther	1	1.100	-	-	LDO	PTHR12747
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3567
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770