Protein Alignment Mrp4 and ABCC12

DIOPT Version :10

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: NP_150229.2
• Gene: ABCC12 / 94160
• HGNCID: 14640
• Length: 1359
• Species: Homo sapiens
• Alignment Length: 1375
• Identity: 432/1375 - (31%)
• Similarity: 715/1375 - (52%)
• Gaps: 165/1375 - (12%)

  Fly     9 LPENPRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAWDEQVAK-- 71
            |..||.:.:..||...|.:..||:.||.::.|....|........||:...|....|||:||:
Human    41 LAPNPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLWDEEVARVG 105

  Fly    72 NETPRLGRALTKVFGFHLFITGVFLLAQEFLTKVTQPICLI------GVMAYFAGNDPDRSKAQL 130
            .|...|...:.|           |...:..:..|...:|:|      .::.:......:|:..::
Human   106 PEKASLSHVVWK-----------FQRTRVLMDIVANILCIIMAAIGPVILIHQILQQTERTSGKV 159

  Fly   131 WAAGLIAGSVFSVCIGHPYMLGL-----LHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVN 190
            |....:..::|:......:...|     ....:::::|||:|::...  :|...|...:||:|:|
Human   160 WVGIGLCIALFATEFTKVFFWALAWAINYRTAIRLKVALSTLVFENL--VSFKTLTHISVGEVLN 222

  Fly   191 LLSND-VGRFDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSV 254
            :||:| ...|:..|.......|..|.:....|..:: :|.:::.|:::.::|:|.|.::.|..|.
Human   223 ILSSDSYSLFEAALFCPLPATIPILMVFCAAYAFFI-LGPTALIGISVYVIFIPVQMFMAKLNSA 286

  Fly   255 LRLRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGILISFAM 319
            .|....|.||:||:.|||.::.|::||||||||.|...::..|..|...:::..:::....:.|.
Human   287 FRRSAILVTDKRVQTMNEFLTCIRLIKMYAWEKSFTNTIQDIRRRERKLLEKAGFVQSGNSALAP 351

  Fly   320 FLSRIFTSSSLIAFVLLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLE--- 381
            .:|.|....:|...:||...|.|..||.|.|.:|:::.|:.: .|..|...||..||:||::
Human   352 IVSTIAIVLTLSCHILLRRKLTAPVAFSVIAMFNVMKFSIAI-LPFSIKAMAEANVSLRRMKKIL 415

  Fly   382 ------AFMHRPE-------------------------TKVRDKSKVKNANQKAESPNGDSPKGN 415
                  :::.:||                         .|::::.:.....|::|:.:..||...
Human   416 IDKSPPSYITQPEDPDTVLLLANATLTWEHEASRKSTPKKLQNQKRHLCKKQRSEAYSERSPPAK 480

  Fly   416 GI--PENLIEFSQFQARWESHSLEPTLEDINLQLGRRKLVAVIGPVGAGKSSLIQAILGELPGES 478
            |.  ||.           :|.||:..|..|:..:.:.|::.:.|.||:|||||:.|:||::..:.
Human   481 GATGPEE-----------QSDSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQK 534

  Fly   479 GTLRINGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCALERDFELLPFGDKTIVGER 543
            |.:.:||:.:|.:|:.|:|.|.||:|||||..:|..||:..|:.|.|::|...||:||.|.:|||
Human   535 GVVAVNGTLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGER 599

  Fly   544 GASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFDQCMRGYLRSELVILVTHQLQF 608
            |.:|||||:.|||||||||....:|||||||||||.|||:|:|::|::..||.:.|:||||||||
Human   600 GLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTHQLQF 664

  Fly   609 LEQADLIVIMDKGRISAMGTYSSMKRS------------GLDF--------AQLLTAPNKDAEDL 653
            ||..|.:::::.|.|...||:..:...            ||.|        |.::.|..:...:.
Human   665 LESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNAAMVEAFKESPAER 729

  Fly   654 DEIDGAGGDGLDLLNVPSLSRRGSKNSKPSTRNNSFTSLSSMAESMAQEASLQMQETRVEGKIGL 718
            :|..|.      ::..|...:...|.|:..         |...::...|..|...|:..||.:..
Human   730 EEDAGI------IVLAPGNEKDEGKESETG---------SEFVDTKVPEHQLIQTESPQEGTVTW 779

  Fly   719 GLYKEYLTSGSSWFMIFFMVFLCLATQILCSAA--DYFLSYWVDKNVDGQTDINTDPQD------ 775
            ..|..|:.:...:.:..|.|||.|.  ::.|||  :::|..|:||.    :.:...||.
Human   780 KTYHTYIKASGGYLLSLFTVFLFLL--MIGSAAFSNWWLGLWLDKG----SRMTCGPQGNRTMCE 838

  Fly   776 -------------MYYFAALNVAVVVFTIVRTMLFYKMAMRSSTQLHNAMYQGITRAAMYFFNTN 827
                         .:.:.|..|.::||.:.:..:|.|..:.:|:.||:.::..|.::.|.||:|.
Human   839 VGAVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVFDKILKSPMSFFDTT 903

  Fly   828 PSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLILTLALAIIFYYIREF 892
            |:||::||||||:.:||..||....:.:|.|..::.|:|::....|..|::..:||:.|:.:...
Human   904 PTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILVILAAVFPAVLLVVASLAVGFFILLRI 968

  Fly   893 YLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSSGYYTFLATN- 956
            :.:..:::|::|.|:|||.::|:::::.||..|.|.|.::..|.             |..|..|
Human   969 FHRGVQELKKVENVSRSPWFTHITSSMQGLGIIHAYGKKESCIT-------------YHLLYFNC 1020

  Fly   957 --RAFGYYLDC---FCTLYIVIIILNYFINPPQSPGEVGLAITQAMGMTGMVQWAMRQSAELENT 1016
              |.|...:|.   ..|..:.:::...|.:  .|....||:::..:.::|::|..:|...|.:..
Human  1021 ALRWFALRMDVLMNILTFTVALLVTLSFSS--ISTSSKGLSLSYIIQLSGLLQVCVRTGTETQAK 1083

  Fly  1017 MTAVERVVEY-DEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYVLKALNFRIR 1080
            .|:||.:.|| ....||.....:.|..|. .||.:|||...|..:||  ......||.:||..|:
Human  1084 FTSVELLREYISTCVPECTHPLKVGTCPK-DWPSRGEITFRDYQMRY--RDNTPLVLDSLNLNIQ 1145

  Fly  1081 PCEKVGIVGRTGAGKSSLINALFRL-SYNEGIITIDERDTADMGLFDLRSKISIIPQEPVLFSGS 1144
            ..:.||||||||:|||||..||||| ....|.|.|||.|...:.|.|||:|:::|||:||||.|:
Human  1146 SGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGT 1210

  Fly  1145 MRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARAILREN 1209
            :||||||||.:.|..||..||...::..|.:||..||::::|.|.|||||:|||:|:|||:||.:
Human  1211 VRYNLDPFESHTDEMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNS 1275

  Fly  1210 RVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYE 1274
            :::::|||||::|.:||.|:|.||:..|:.||||||||||||:::.|.||||:.|.::||..| |
Human  1276 KIILLDEATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKP-E 1339

  Fly  1275 LLTSSESKIF 1284
            :|.......|
Human  1340 VLAEKPDSAF 1349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	MRP_assoc_pro	13..1292	CDD:188098	430/1371 (31%)
ABCC12	NP_150229.2	MRP_assoc_pro	43..1344	CDD:188098	430/1366 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	446..491		9/55 (16%)