Protein Alignment Mrp4 and ABCC10

DIOPT Version :10

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: XP_054212675.1
• Gene: ABCC10 / 89845
• HGNCID: 52
• Length: 1543
• Species: Homo sapiens
• Alignment Length: 1367
• Identity: 443/1367 - (32%)
• Similarity: 687/1367 - (50%)
• Gaps: 159/1367 - (11%)

  Fly     7 DELPENPRERSSPLSSLMFCFALPVLFKGRKKTLEQ-KDLYRALKEHKSDSLGDRLCAAWDEQVA 70
            |:.||...:..|.||...:.:..|:|.:|....|.| :|:.|.....:...|.....|.|.|..
Human   259 DQEPEVAEDGESWLSRFSYAWLAPLLARGACGELRQPQDICRLPHRLQPTYLARVFQAHWQEGA- 322

  Fly    71 KNETPRLGRALTKVFGFHLFITGVFLLAQEFLTKVTQPICLIGVMAYFAGNDPDRSKAQLWAAGL 135
                 ||.|||...||......|:..|....| ..:.|:.|..::.:........|...|:|.||
Human   323 -----RLWRALYGAFGRCYLALGLLKLVGTML-GFSGPLLLSLLVGFLEEGQEPLSHGLLYALGL 381

  Fly   136 IAGSVFSVCIGHPYMLGLLHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLLSNDVGRFD 200
            ..|:|....:.:.|...:..:.::.|.|:.:::|.|||:|..:.   ...|:.:|||..|..|
Human   382 AGGAVLGAVLQNQYGYEVYKVTLQARGAVLNILYCKALQLGPSR---PPTGEALNLLGTDSER-- 441

  Fly   201 LVLIN----VHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVLRLRTAL 261
              |:|    .|..|..||:|....||:|.::|::.:.|:.:.||.:|....:..|..........
Human   442 --LLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVGGLILALLLVPVNKVIATRIMASNQEMLQ 504

  Fly   262 RTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGILISFAMFLSRIFT 326
            ..|.||:::.|::|||:|||...||:..|..||..|..|:..::.:.|:....:.....|..:.:
Human   505 HKDARVKLVTELLSGIRVIKFCGWEQALGARVEACRARELGRLRVIKYLDAACVYLWAALPVVIS 569

  Fly   327 SSSLIAFVLLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAFMHRPETKV 391
            ....|.:||:|:.|.|.|.|...|...:|...:.. ||..|:...|..||:.|::.|:..|
Human   570 IVIFITYVLMGHQLTATKVFTALALVRMLILPLNN-FPWVINGLLEAKVSLDRIQLFLDLP---- 629

  Fly   392 RDKSKVKNANQKAESPNGDSPKGNGIPENLIEFSQFQARWE--SHSLEPTLEDINLQLGRRKLVA 454
                   |.|.:|..    ||.....|..::|.......|:  ..|||..:..:.::.|  .||.
Human   630 -------NHNPQAYY----SPDPPAEPSTVLELHGALFSWDPVGTSLETFISHLEVKKG--MLVG 681

  Fly   455 VIGPVGAGKSSLIQAILGELPGESGTLRING---SYSYAAQEPWLFTGTVRQNILFGLDWDKHRY 516
            ::|.||.|||||:.||.|||....|.:.:.|   .:..|.||||:...|:|.|||||..:|...|
Human   682 IVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKGFGLATQEPWIQFATIRDNILFGKTFDAQLY 746

  Fly   517 RTVVKKCALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHV 581
            :.|::.|||..|..:||.||:|.|||:|.:|||||:|||:||||||:..::|||||||:|||..|
Human   747 KEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKELYLLDDPLAAVDADV 811

  Fly   582 GRHLFDQCMRGYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRSGLDFAQLLTAP 646
            ..||..:|:.|.|.....:|.||:.::||:||.:::|:.||:...|..|.:    |...|  ..|
Human   812 ANHLLHRCILGMLSYTTRLLCTHRTEYLERADAVLLMEAGRLIRAGPPSEI----LPLVQ--AVP 870

  Fly   647 NKDAEDLDEIDGAGGDGLDLLNVPSLSRRGSKNSKPSTRNNSFTSLSSMAESMAQEASLQMQETR 711
            ...||:..|.|.|                    :..|.:|...|. ..:.|..:....|..:|::
Human   871 KAWAENGQESDSA--------------------TAQSVQNPEKTK-EGLEEEQSTSGRLLQEESK 914

  Fly   712 VEGKIGLGLYKEYLTSGSSW--------FMIFFMVFLCLATQILCSAADYFLSYWVD----KNVD 764
            .||.:.|.:|:.|      |        ..|.|.:.|..||:   :|||::||:|:.    :|..
Human   915 KEGAVALHVYQAY------WKAVGQGLALAILFSLLLMQATR---NAADWWLSHWISQLKAENSS 970

  Fly   765 GQTDINTDPQDM-------YYFAALNVAVVVF------------------------------TIV 792
            .:...:|.|..|       ..|:..|:.:.||                              |::
Human   971 QEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDIRFYLTVYATIAGVNSLCTLL 1035

  Fly   793 RTMLFYKMAMRSSTQLHNAMYQGITRAAMYFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQL 857
            |.:||....::::..||..:...:..|.:.|||..|:||||||||.|:...|:.||.::..::..
Human  1036 RAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRILNRFSSDVACADDSLPFILNILLAN 1100

  Fly   858 FLTLLGIIVVICITNPYYLILTLALAIIFYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGL 922
            ...|||::.|:....|:.|:|...|:|::|:::..|..:||:::||.::..||:||||:.|:.||
Human  1101 AAGLLGLLAVLGSGLPWLLLLLPPLSIMYYHVQRHYRASSRELRRLGSLTLSPLYSHLADTLAGL 1165

  Fly   923 PTIRALGAQKELIAEFDNLQDLHSSGYYTFLATNRAFGYYLDCFCTLY---IVIIILNYFINPPQ 984
            ..:||.||......|...|.:|:....:...||.:    :||....|.   :|..|....:...|
Human  1166 SVLRATGATYRFEEENLRLLELNQRCQFATSATMQ----WLDIRLQLMGAAVVSAIAGIALVQHQ 1226

  Fly   985 ----SPGEVGLAITQAMGMTGMVQWAMRQSAELENTMTAVERVVEYD---EIEPEGEFDSREGKK 1042
                :||.|||:::.|:.:||::...:....:.|..:.:|||:.||.   ..||:|:
Human  1227 QGLANPGLVGLSLSYALSLTGLLSGLVSSFTQTEAMLVSVERLEEYTCDLPQEPQGQ-------- 1283

  Fly  1043 P---SPSWPEKGEIIAEDLCLRYFPD-PQAKYVLKALNFRIRPCEKVGIVGRTGAGKSSLINALF 1103
            |   ...|..:|.:..:|:.|.|.|. |.|   |..:.|.::|.||:|||||||:|||||:..||
Human  1284 PLQLGTGWLTQGGVEFQDVVLAYRPGLPNA---LDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLF 1345

  Fly  1104 R-LSYNEGIITIDERDTADMGLFDLRSKISIIPQEPVLFSGSMRYNLDPFEEYNDAKLWDALEEV 1167
            | |..:.|.:.:|..||:.:.|..|||:::||||||.||||::|.||||...:.|..||.||::.
Human  1346 RLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQC 1410

  Fly  1168 KLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARAILRENRVLVMDEATANVDPQTDALIQAT 1232
            .|..:|:.: .||..::.|||.:.|:|||||:|||||:|.:.::|.:|||||:||.:||.|:|.|
Human  1411 HLSEVITSM-GGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQT 1474

  Fly  1233 IRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYELLTSSESKIFHGMVMETGQNTFD 1297
            |..:|.:.||||||||||||::||||||:.||.:||..||..|.....| :|..::..:.|....
Human  1475 ICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHS-LFQQLLQSSQQGVPA 1538

  Fly  1298 SL 1299
            ||
Human  1539 SL 1540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	MRP_assoc_pro	13..1292	CDD:188098	437/1352 (32%)
ABCC10	XP_054212675.1	MRP_assoc_pro	<324..1520	CDD:188098	420/1273 (33%)