Protein Alignment Mrp4 and abcc13

DIOPT Version :10

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: XP_073796816.1
• Gene: abcc13 / 559093
• ZFINID: ZDB-GENE-050517-26
• Length: 1025
• Species: Danio rerio
• Alignment Length: 1332
• Identity: 276/1332 - (20%)
• Similarity: 490/1332 - (36%)
• Gaps: 408/1332 - (30%)

  Fly    24 MFCF-ALPVLFKGRKKTLEQK---DLYRALKEHKSDSLGDRLCAAWDEQVAKNE----------- 73
            ::|| ..|||:..|...:..:   .|:..||.:..||: ..||:.:|.:..|.:
Zfish    15 LYCFQTSPVLYNMRMVVMGHRGPLQLFDLLKLYNEDSV-HTLCSVFDHEWEKQQNNYKERSDLED 78

  Fly    74 ---------TPRLGRALTKVF----GFHLFITGVFLL-AQEFLTKVTQPICLIGVMAYFAGNDPD 124
                     |.:.....:.::    .||..:..:.|| ....|..:..||.:..|:.:     .:
Zfish    79 DSGRKSLLVTSKTNAGYSLLYTLWKTFHPSLIKIVLLRLSSDLFSILVPITIRWVILF-----SE 138

  Fly   125 RSKAQLWAAGLIAGSVF-SVCIG----HPYMLGLLHLGMKMRI-------ALSSLIYR--KALRL 175
            |.....|.....|..|| ::|.|    |       |...:.||       .||..:||  |.|.|
Zfish   139 RQAMFGWTGYTYALVVFGALCCGAFSQH-------HFEKRSRIITANAHAILSGTVYRKIKTLSL 196

  Fly   176 SRTALGDTTVGQVVNLLSNDVGRFDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLL 240
            |.::...:......::| .:..|...:::.:..:|.:||.:.....|::.::|.|.:.||.::|:
Zfish   197 SHSSRWHSDTSHREDML-GEAERVAELVVTLACIWSSPLRVTLYLGLLWAKLGPSVLVGVTLLLV 260

  Fly   241 FLPFQSYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIK 305
            .:|.:|.:.::...||....:..::..:::.|::...|.:|:..||..|.:.|..:|..|:..::
Zfish   261 LIPVKSAVERKAKQLRRTHRVIREKSEQLIKEMLHKYQALKLLTWESWFFQRVTESRTRELEMLR 325

  Fly   306 QVNYIRGILISFAMF----LSRIFTSSSLIAFVLL--GNILNAEKAFFVTAYYNILRRSVTMFFP 364
                |:|.|.:|:|.    :..:...|||.||||:  ||:|.:.:.|....::.:||
Zfish   326 ----IQGFLTAFSMLDSICMPFLVIFSSLGAFVLVDDGNVLTSSQIFTSVCFFRLLR-------- 378

  Fly   365 QGISEFAELLVSVRRLEAFMHRPETKVRDKSKVKNANQKAESPNGDSPKGNGIPENLIEFSQFQA 429
                                                                             
Zfish   379 ----------------------------------------------------------------- 378

  Fly   430 RWESHSLEPTLEDINLQLGRRKLVAVIGPVGAGKSSLIQAILGELPGESGTLRINGSYSYAAQEP 494
                   .|.||.:                                         |.:|...|..
Zfish   379 -------PPLLEFL-----------------------------------------GLFSVLKQAQ 395

  Fly   495 WLFTGTVRQNILFGLDWDKHRYRTVVKKCALERDFELLPFGDKTIVGERGASLSGGQKARISLAR 559
            ..|                         |.||:.|.....|....: .:||:
Zfish   396 QSF-------------------------CYLEKIFLTEDLGTSQFL-TKGAT------------- 421

  Fly   560 AVYRRADIYLLDDPLSAVDTHVGRHLFDQCMRGYLRSELVILVTHQLQFLEQADLIVIMDKGRIS 624
                        :..||..|   :...|:|..                  :|.|
Zfish   422 ------------EESSADST---QQPCDECQE------------------KQND----------- 442

  Fly   625 AMGTYSSMKRSGLDFAQLLTAPNKDAEDLDEIDGA-----GGDGLDLLNVPSLSRRGSKNSKPST 684
                 |..||....|.             :|...|     |..|...::|.||
Zfish   443 -----SDEKRDHYHFR-------------NEFREACWLYLGAFGWHWVSVCSL------------ 477

  Fly   685 RNNSFTSLSSMAESMAQEASLQMQETRVEGKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCS 749
                 ..||..|.|:||:..|.|.....:...||..:||...|..|.:.:..:    |...::|.
Zfish   478 -----VYLSVCAVSLAQDGVLCMWTGEAKEVQGLDGWKELRNSRLSAYALLGL----LQAFLVCC 533

  Fly   750 AADYFLSYWVDKNVDGQTDINTDPQDMYYFAALNVAVVVFTIVRTMLFYKMAMRSSTQLHNAMYQ 814
            || |.|:..                                          ::::|..||..:..
Zfish   534 AA-YCLTCG------------------------------------------SLKASRTLHTELLS 555

  Fly   815 GITRAAMYFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLILT 879
            .:....::....| :.:::...::|:..:||.||..:..:::..|.:|..|.:|....|.:.:..
Zfish   556 DVLHLPVHSQKMN-TRKLMQALTQDMQVIDEELPKHLHSILKSLLDVLSTITLISFIIPVFSLAV 619

  Fly   880 LALAIIFYYIREFYLKTSRDVKRLEAVARSPIYSHLS---------ATITGLPTIRALGAQKELI 935
            ..:.|:..:|:.....|...::.:||   :|..|..|         |:::| |..||:..:..|.
Zfish   620 CPMIILLLHIQSRISSTHMQIRNMEA---NPAVSLTSLARVTQCAEASLSG-PEHRAVCLKHCLQ 680

  Fly   936 AEFDNLQDLHSSGYYTFLATNRAFGYYLDCFCTLY---------IVIIILNYFI--NPPQSPGEV 989
            |...||           |...........|.|:..         ||:::::..:  ..|:| |.|
Zfish   681 AFTQNL-----------LLKYNTINTESICVCSWVVLWFDGVAGIVLLLVSLILLQTQPES-GLV 733

  Fly   990 GLAITQAMGMTGMVQWAMRQSAELENTMTAVERVVEYDEIEPEGEFDSREGKKPSPSWPEKGEII 1054
            .|.:..:..:...:.:..:.::.:...|.:::.:  :|..:.|.|.:.....:|...||:.||:.
Zfish   734 ALTLICSFNIKEALHYCPQAASVITTDMLSLQNL--FDSAKAEKEAEWTVNYRPPYDWPQHGEVK 796

  Fly  1055 AEDLCLRYFPDPQAKY----VLKALNFRIRPCEKVGIVGRTGAGKSSLINALFR-LSYNEGIITI 1114
            ..:.      :.:|..    .|:.::..|...||:|:|.|.......|||:||| :....|.:.|
Zfish   797 FRNY------ESEASSDGTPALRGVHLTILKGEKIGVVSRQKTDTDVLINSLFRSVEARSGALLI 855

  Fly  1115 DERDTADMGLFDLRSKISIIPQEPVLFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNG 1179
            |..:.:.|||.|||.::.||.|.||||||.:|.|||||.|::||::|.|||...||..:.::|..
Zfish   856 DNINISRMGLHDLRGRLQIISQVPVLFSGPLRANLDPFAEHSDAQVWLALELCHLKESVQQMPAQ 920

  Fly  1180 LQSKISEGGSNFSVGQRQLVCLARAILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLT 1244
            |...:......||.|||:|:|||||:|...|:|:::|...:|||:|:.|:|..|.::|:|||||.
Zfish   921 LLHPVQRTALAFSFGQRRLLCLARALLARVRILLVEEPLHHVDPETEDLLQQVIHAEFKDCTVLF 985

  Fly  1245 IAHRLNTIMDSDRVLVMDAGHLVEFGSPYELL 1276
            ::....:::.:|||||:|.|..|:|.:|..||
Zfish   986 LSQNPLSVLHTDRVLVLDKGQAVKFDAPSTLL 1017

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	MRP_assoc_pro	13..1292	CDD:188098	276/1332 (21%)
abcc13	XP_073796816.1	None