Protein Alignment Mrp4 and ABCC1

DIOPT Version :10

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: XP_047290087.1
• Gene: ABCC1 / 4363
• HGNCID: 51
• Length: 1584
• Species: Homo sapiens
• Alignment Length: 1381
• Identity: 493/1381 - (35%)
• Similarity: 756/1381 - (54%)
• Gaps: 161/1381 - (11%)

  Fly    13 PRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAWDEQVAK------ 71
            |...:|.||.:.|.:...::.:|.::.||..||:...||..|:.:...|...|.::.||
Human   262 PESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPV 326

  Fly    72 --------------------NE--------------TPRLGRALTKVFGFHLFITGVFLLAQEFL 102
                                ||              .|.|.:.|.|.||.: |:...|..|...|
Human   327 KVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPY-FLMSFFFKAIHDL 390

  Fly   103 TKVTQPICLIGVMAYFAGNDPDRSKAQLWAAGLIAGSVF-SVCIG----HPYMLGLLHLGMKMRI 162
            ...:.|..|..::.:.  ||   :||..|........:| :.|:.    |.|.......||:::.
Human   391 MMFSGPQILKLLIKFV--ND---TKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKT 450

  Fly   163 ALSSLIYRKALRLSRTALGDTTVGQVVNLLSNDVGRFDLVLINVHYLWIAPLELIAVTYLMYLEI 227
            |:...:|||||.::.:|...:|||::|||:|.|..||..:...::.:|.|||::|...||::|.:
Human   451 AVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNL 515

  Fly   228 GISSMFGVAIMLLFLPFQSYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKV 292
            |.|.:.|||:|:|.:|..:.:..:|...::......|.|:::||||::||:|:|:||||..|...
Human   516 GPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDK 580

  Fly   293 VEMTRFNEMLCIKQVNYIRGI-------------LISFAMFLSRIFTSSSLIAFVLLGNILNAEK 344
            |...|..|:..:|:..|:..:             |.:||::::           :...|||:|:.
Human   581 VLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVT-----------IDENNILDAQT 634

  Fly   345 AFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAFMHRPETKVR--DKSKVKNANQKAESP 407
            ||...|.:||||..:.: .|..||...:..||::||..|:...|.:..  ::..||:
Human   635 AFVSLALFNILRFPLNI-LPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKD-------- 690

  Fly   408 NGDSPKGNGIPENLIEFSQFQARWESHSLEPTLEDINLQLGRRKLVAVIGPVGAGKSSLIQAILG 472
                  |.|  .|.|........| :.|..|||..|...:....||||:|.||.|||||:.|:|.
Human   691 ------GGG--TNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLA 746

  Fly   473 ELPGESGTLRINGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCALERDFELLPFGDK 537
            |:....|.:.|.||.:|..|:.|:...::|:|||||...::..||:|::.|||..|.|:||.||:
Human   747 EMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDR 811

  Fly   538 TIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFDQCM--RGYLRSELVI 600
            |.:||:|.:||||||.|:|||||||..|||||.||||||||.|||:|:|:..:  :|.|:::..|
Human   812 TEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRI 876

  Fly   601 LVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRSGLDFAQLL-----TAPNKDAEDLDEIDGAG 660
            ||||.:.:|.|.|:|::|..|:||.||:|..:......||:.|     |...:|||: :.:.|..
Human   877 LVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEE-NGVTGVS 940

  Fly   661 GDGLDLLNVPS-----------LSRRGSKNSKPS---TRNNSFTSLSSMAESMAQEASLQMQETR 711
            |.|.:...:.:           |.|:.|.:|..|   :|:::.|:....||:..:|....|:..:
Human   941 GPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADK 1005

  Fly   712 VE-GKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSAADYFLSYWVDKNVDGQTDINTDPQD 775
            .: |::.|.:|.:|: .....|:.|..:||.:...:...|::|:||.|.|..:...|..:|..:
Human  1006 AQTGQVKLSVYWDYM-KAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVR- 1068

  Fly   776 MYYFAALNVA--VVVFTIVRTMLFYKMAMR-----SSTQLHNAMYQGITRAAMYFFNTNPSGRIL 833
            :..:.||.::  :.||.       |.||:.     :|..||..:...|.|:.|.||...|||.::
Human  1069 LSVYGALGISQGIAVFG-------YSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLV 1126

  Fly   834 NRFSKDLGQLDEVLPSVMLDVVQLFL----TLLGIIVVICITNPYYLILTLALAIIFYYIREFYL 894
            |||||:|..:|.::|    :|:::|:    .::|..:||.:..|...|:...|.:|:::::.||:
Human  1127 NRFSKELDTVDSMIP----EVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYV 1187

  Fly   895 KTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSSGYYTFLATNRAF 959
            .:||.:||||:|:|||:|||.:.|:.|:..|||...|:..|.:.|...|.:...||..:..||..
Human  1188 ASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWL 1252

  Fly   960 GYYLDC-------FCTLYIVIIILNYFINPPQSPGEVGLAITQAMGMTGMVQWAMRQSAELENTM 1017
            ...|:|       |..|:.||      .....|.|.|||:::.::.:|..:.|.:|.|:|:|..:
Human  1253 AVRLECVGNCIVLFAALFAVI------SRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNI 1311

  Fly  1018 TAVERVVEYDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYVLKALNFRIRPC 1082
            .||||:.||.|.|.|..:..:|...|| |||:.|.:...:.||||..|  ..:||:.:|..|...
Human  1312 VAVERLKEYSETEKEAPWQIQETAPPS-SWPQVGRVEFRNYCLRYRED--LDFVLRHINVTINGG 1373

  Fly  1083 EKVGIVGRTGAGKSSLINALFRLSYN-EGIITIDERDTADMGLFDLRSKISIIPQEPVLFSGSMR 1146
            ||||||||||||||||...|||::.: ||.|.||..:.|.:||.|||.||:||||:|||||||:|
Human  1374 EKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLR 1438

  Fly  1147 YNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARAILRENRV 1211
            .|||||.:|:|.::|.:||...||..:|.||:.|..:.:|||.|.|||||||||||||:||:.::
Human  1439 MNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKI 1503

  Fly  1212 LVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYELL 1276
            ||:|||||.||.:||.|||:|||::|.||||||||||||||||..||:|:|.|.:.|:|:|.:||
Human  1504 LVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLL 1568

  Fly  1277 TSSESKIFHGMVMETG 1292
              .:..:|:.|..:.|
Human  1569 --QQRGLFYSMAKDAG 1582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	MRP_assoc_pro	13..1292	CDD:188098	492/1379 (36%)
ABCC1	XP_047290087.1	MRP_assoc_pro	70..1583	CDD:188098	493/1381 (36%)