Protein Alignment Mrp4 and rdog

DIOPT Version :10

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: NP_651678.1
• Gene: rdog / 43450
• FlyBaseID: FBgn0039644
• Length: 1374
• Species: Drosophila melanogaster
• Alignment Length: 1367
• Identity: 578/1367 - (42%)
• Similarity: 830/1367 - (60%)
• Gaps: 97/1367 - (7%)

  Fly    10 PENPRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAWDEQVAKNET 74
            |:||..:::..|...|.:...:..:|.:..|..::||:..|...|:.:.::....|:::: |...
  Fly    11 PKNPFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSERVTNKFAELWEDEL-KRSN 74

  Fly    75 PRLGRALTKVFGFHLFITGVFLLAQEFLTKVTQPICLIGVMAYFAGNDPDRSK--AQLWAAGLIA 137
            |.:.|.:.:.:|......|:.....|.:.|...|:.|.|::.|||.|..|.|:  |.|:|.|::.
  Fly    75 PSVVRMILRAYGKIFVPMGLAFSISETICKSLMPLFLGGLVGYFATNQTDISENTAYLYAMGIVI 139

  Fly   138 GSVFSVCIGHPYMLGLLHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLLSNDVGRFDLV 202
            ..:..|...||::..:..:|.|:|:|||.|||||.|::|:::..|...|:.:|:||||:||||:.
  Fly   140 CMLVPVITFHPFIFYIFQVGTKLRLALSGLIYRKVLQVSKSSSNDGLRGRAINILSNDLGRFDVA 204

  Fly   203 LINVHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVLRLRTALRTDERV 267
            |..:|..|..|:|.|.:.:|||.|||||::.||:.||.|:|.|::..|:.:..|..||.|||.||
  Fly   205 LCFLHDTWKGPMESILIGFLMYREIGISAVIGVSFMLSFIPLQAWAAKKAAYYRQMTAERTDMRV 269

  Fly   268 RMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGILISFAMFLSRIFTSSSLIA 332
            ::|||||.||||||||||||.|.:|:...|..|:..|:...||...|...:| :|.:....:|.:
  Fly   270 KLMNEIIQGIQVIKMYAWEKSFARVIAEVRLKEVKAIRGTAYIHAALGCTSM-ISPLSVFLALCS 333

  Fly   333 FVLLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAFM---HRPETKV--- 391
            :|.||:.|.|:|.:.|::|:|:|..|:..|:|..|:..||.|||.:|.:.|:   .:.|..:
  Fly   334 YVYLGDPLTAQKVYTVSSYFNMLNDSMVTFWPMSITFIAEALVSAKRCKDFLLDGDKAEVPINLE 398

  Fly   392 ------RDKSKV-KNANQKAESPNGDSPKGNG----------IPE---NLIEFSQFQARWES--- 433
                  ::|.|: |...||....|| |...||          .||   ..:......|.|::
  Fly   399 ANQQTGKNKRKISKKDKQKNVELNG-SLLSNGQVHHNRLRDYDPEATKKCVVLKNVSASWDTSDG 462

  Fly   434 HSLEPTLEDINLQLGRRKLVAVIGPVGAGKSSLIQAILGELPGESGTLRINGSYSYAAQEPWLFT 498
            |: ...:||.:..:..:.|.||:|||||||||.:..:|||:..:.|...::|..|||:||.|:|.
  Fly   463 HA-NCAIEDFSTDIKDQTLAAVVGPVGAGKSSFLNVLLGEVGIDKGEAMVHGKISYASQESWVFE 526

  Fly   499 GTVRQNILFGLDWDKHRYRTVVKKCALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYR 563
            ||:|.||:|..|:::.||:.|||.|.||||.||||.||.|:|||||.|||||||||:||||||||
  Fly   527 GTIRDNIVFVEDYNERRYKKVVKVCGLERDMELLPRGDLTVVGERGVSLSGGQKARVSLARAVYR 591

  Fly   564 RADIYLLDDPLSAVDTHVGRHLFDQCMRGYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGT 628
            :||||||||||||||||||:|:||:|:|.:|.:::.||||||:|:|...:.:::|..|:|.|.|:
  Fly   592 KADIYLLDDPLSAVDTHVGKHIFDRCIRDFLSNKIRILVTHQVQYLFDVEHLLLMGSGKIMAQGS 656

  Fly   629 YSSMKRSGLDFAQLLTAPNKDAEDLDEIDGAGGDGLDLLNVPSLSRRGSKNSKPSTRNNSFTSLS 693
            |..::|| ..| |.|.....|.           .|:|..:|.|...|.........::|......
  Fly   657 YQELQRS-RQF-QFLEQTQHDE-----------SGIDTHSVSSYLSRSDSEKSMEHQHNQLLRPD 708

  Fly   694 SMAESMAQEASLQMQETRVEGKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSAADYFLSYW 758
            ...|.:.||     |:|  .|.|.:.:|..|:.:..|.|::..::.|.:..:|:.:..|||||.|
  Fly   709 EHVEDVNQE-----QQT--VGSIKMHVYASYIKALDSTFLLGIVISLFVCARIMLTGVDYFLSRW 766

  Fly   759 V------------------DKNVDGQT-DIN-TDP---------------QD--MYYFAALNVAV 786
            |                  |..:...| .|| |||               |:  ::|...|...:
  Fly   767 VIWEEQIAVNRTTTLLNETDTTIANDTLPINATDPYIAPLLASDIQAGIRQELVLFYATILGATL 831

  Fly   787 VVFTIVRTMLFYKMAMRSSTQLHNAMYQGITRAAMYFFNTNPSGRILNRFSKDLGQLDEVLPSVM 851
            :|: ::||..|:||.:|.|..||:.:::|||||:|||||||.|||||||||||:..:|..||..:
  Fly   832 IVY-LIRTFGFFKMCLRISLHLHDRLFRGITRASMYFFNTNSSGRILNRFSKDIRTVDTDLPHTL 895

  Fly   852 LDVVQLFLTLLGIIVVICITNPYYLILTLALAIIFYYIREFYLKTSRDVKRLEAVARSPIYSHLS 916
            ||.:...:.:.|:::::.|.|.:.||....:.:|...||..|:.|||.|||||:::|||::|..:
  Fly   896 LDCLAFIIDVSGVVIIVAIANYWLLIPAAIIGVILGMIRYLYVNTSRSVKRLESISRSPVFSLTN 960

  Fly   917 ATITGLPTIRALGAQKELIAEFDNLQDLHSSGYYTFLATNRAFGYYLDCFCTLYIVIIILNYFIN 981
            .|..||.|||||.||..|..||...|:.::|.::.||:..|||..:.|..|.:|:..:..::.:.
  Fly   961 QTFQGLTTIRALQAQSALEQEFHEYQNTNTSAWFLFLSCTRAFALWSDVLCIVYMTAVTFSFLLL 1025

  Fly   982 PPQ-SPGEVGLAITQAMGMTGMVQWAMRQSAELENTMTAVERVVEYDEIEPEGEFDSREGKKPSP 1045
            ..: ..|:|||||..:..||||.||.|||:|||||.||:||||:||.|...|...::.|..||..
  Fly  1026 KDEFDSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERVLEYTEQPSEALLETPEKFKPKS 1090

  Fly  1046 SWPEKGEIIAEDLCLRYFPDPQAKYVLKALNFRIRPCEKVGIVGRTGAGKSSLINALFRLSYNEG 1110
            .||.||.|...:..|||  .|:...|||.|||.|.|.||:||||||||||||:|.::|||:.|||
  Fly  1091 EWPSKGRIEFINFKLRY--SPKEAPVLKDLNFTIEPREKIGIVGRTGAGKSSIIQSIFRLACNEG 1153

  Fly  1111 IITIDERDTADMGLFDLRSKISIIPQEPVLFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISE 1175
            :|.||:.|...:||.||||::|||||:||||||::||||||.:|.:|.::|.||.:|:|:..:|.
  Fly  1154 MIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLDPMDERSDEEMWKALGDVELRSYVST 1218

  Fly  1176 LPNGLQSKISEGGSNFSVGQRQLVCLARAILRENRVLVMDEATANVDPQTDALIQATIRSKFRDC 1240
            |..||..::.:|||||||||||||||||||||.|::|:||||||||||:||.|||.||||||..|
  Fly  1219 LIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMDEATANVDPETDKLIQQTIRSKFAHC 1283

  Fly  1241 TVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYELLTSSESKIFHGMVMETGQNTFDSLLKVAEK 1305
            |||||||||:|:||||||||||||.:.|.|.|||||..:...: ..:|..||..|..:|.:.||:
  Fly  1284 TVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQRTGGYL-RQLVDNTGAATSFALQQAAEQ 1347

  Fly  1306 AH 1307
            ::
  Fly  1348 SY 1349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	MRP_assoc_pro	13..1292	CDD:188098	570/1347 (42%)
rdog	NP_651678.1	MRP_assoc_pro	14..1323	CDD:188098	569/1335 (43%)