Protein Alignment Mrp4 and Cftr

DIOPT Version :10

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: NP_651269.1
• Gene: Cftr / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Alignment Length: 1428
• Identity: 614/1428 - (42%)
• Similarity: 841/1428 - (58%)
• Gaps: 167/1428 - (11%)

  Fly    11 ENPRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAWDEQV----AK 71
            :|||:.::.:|.|:|.:|:|:|::|.::.|...||.:.|||.:|:.|||||...|.:::    .|
  Fly    10 KNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSHRK 74

  Fly    72 NETPRLGRALTKVFGFHLFITGVF-------------LLAQEFLTKVTQPIC------------- 110
            .:.|.|..||.:.|.....|.|:.             :|||..:.....|:.
  Fly    75 KQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNIDVNDISIS 139

  Fly   111 --------------LIGVMAYFAGN----------------DP-------------------DRS 126
                          |...:|..:|:                :|                   |::
  Fly   140 DSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNATAVRSILDQT 204

  Fly   127 KAQLW------AAGLIAGSVFSVCIGHPYMLGLLHLGMKMRIALSSLIYRKALRLSRTALGDTTV 185
            ...:|      .|.|:..::|...:.|...|....:|.:||||..||||||.||||....|.|..
  Fly   205 VEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRLMGARMRIACCSLIYRKTLRLSMKTAGQTPA 269

  Fly   186 GQVVNLLSNDVGRFDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMFG-VAIMLLFLPFQSYLG 249
            |.::|||||||.|.|...|.:|::||.||:.:...||::|.|||.::.| |.::|..:|.|:.|.
  Fly   270 GYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVPVQTALS 334

  Fly   250 KRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGIL 314
            |.|||||:|.|.|||.||.:|||::.||||||||||||||..||...|.:|:..|:..:|:||..
  Fly   335 KVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIRYASYLRGFY 399

  Fly   315 ISFAMFLSRIFTSSSLIAFVLLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRR 379
            :|..:|..|.....:|.|..|:|..:.|:..|...:|||||:....:::|..:|..||.|||:||
  Fly   400 LSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQLVAAIWYPLAVSFGAEALVSLRR 464

  Fly   380 LEAFM---HRPETKVRDKSKVKNANQKAESPNGDSPKGNGIPENLIEFSQFQARWESHSLEPTLE 441
            ::.|:   .|.|       :.:....|.:...|||        ..:......|.|:....:.||:
  Fly   465 IQDFLMLEGREE-------RTQGLTHKRDQEGGDS--------RAVTIKDINASWDIEKPQKTLQ 514

  Fly   442 DINLQLGRRKLVAVIGPVGAGKSSLIQAILGELPGESGTLRINGSYSYAAQEPWLFTGTVRQNIL 506
            .||||:.:.:|.||||||||||||::|.:|||||...|.:.|.|..||||||||||||:||.|||
  Fly   515 SINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGDLSYAAQEPWLFTGSVRNNIL 579

  Fly   507 FGLDWDKHRYRTVVKKCALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLD 571
            ||.::|:.||:.|.:.|||..||:.||.||||:||||||||||||:||||||||||:.|.|||:|
  Fly   580 FGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQIYLMD 644

  Fly   572 DPLSAVDTHVGRHLFDQCM--RGYLRSELV---ILVTHQLQFLEQADLIVIMDKGRISAMGTYSS 631
            |||||||.||||||||:.:  ||.| ::|.   ||||||:.||.:||:|||:|:|||...|||..
  Fly   645 DPLSAVDAHVGRHLFDEVIGPRGRL-AQLKATRILVTHQVHFLSEADVIVIVDQGRILRQGTYQE 708

  Fly   632 MKRSGLDFAQLLTAPNK---------------------DAEDLDEIDGAGGDGLDLLNVPSLSRR 675
            :..|.||||:||..|.:                     |.||:..|||. .||...|...|.|..
  Fly   709 LINSDLDFARLLERPKEEEEGENSRNQTSPLSVNSLESDDEDIPFIDGV-KDGYQQLRKQSSSVH 772

  Fly   676 GSKNSKPSTRNNSFTSLSSMAESMAQEASLQMQETRVEGKIGLGLYKEYLTSGSSWFMIFFMVFL 740
            ||| |..||:.:.......:||:.|            .|.|...::.||..:||:.....||||:
  Fly   773 GSK-SLDSTQLDDNVDEDDLAEAQA------------SGGISPRVWYEYFHAGSTLLSFSFMVFV 824

  Fly   741 CLATQILCSAADYFLSYWVD---KNVDGQTDINTDPQDMYYFAALNVAVVVFTIVRTMLFYKMAM 802
            .:.:|::||::|:|.:.|..   :...|:...:|. :.||.:.||.:|||:.|..|..||:|:.|
  Fly   825 MVMSQVVCSSSDFFANIWTQQEHQRSQGEATFSTF-ECMYIYGALIIAVVIMTTFRGFLFFKICM 888

  Fly   803 RSSTQLHNAMYQGITRAAMYFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVV 867
            .:|..||:.|:..|..|.|.||:|.||||||||||||:|.:||:||..|:|.:|:.|.:.||::|
  Fly   889 HASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIV 953

  Fly   868 ICITNPYYLILTLALAIIFYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQK 932
            |.|.||..:...|.:|::...|.:.||:.|:|:||||.:.|||::|||||::|||..||:...|.
  Fly   954 IGILNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQD 1018

  Fly   933 ELIAEFDNLQDLHSSGYYTFLATNRAFGYYLDCFCTLYIVIIILNYFINPPQS-PGEVGLAITQA 996
            .:..|||.|||:|||.:...:|.|...|.:|||...:::..:..::.|:...: .|.|||||.||
  Fly  1019 VVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCVSCIFLTSVTFSFIISSETTYSGNVGLAIAQA 1083

  Fly   997 MGMTGMVQWAMRQSAELENTMTAVERVVEYDEIEPE---GEFDSREGKKPSPSWPEKGEIIAEDL 1058
            |.:|||||:.:||.||....||:||||::|.|:|.|   ||      |.|...||.:|::...::
  Fly  1084 MILTGMVQYGVRQVAESLQQMTSVERVLQYTELEQEPALGE------KTPPQQWPTRGQVEFRNM 1142

  Fly  1059 CLRYFPDPQAKYVLKALNFRIRPCEKVGIVGRTGAGKSSLINALFRLSYNEGIITIDERDTADMG 1123
            ..||  ||....||:.||..|....||||||||||||||||.|||||::.||.|.||..:|..:.
  Fly  1143 SCRY--DPNGSPVLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAHIEGEIFIDGIETGTIS 1205

  Fly  1124 LFDLRSKISIIPQEPVLFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGG 1188
            |..||::||||||:|||||.::||||||||.|.||:||.|||:|:|:..|.    ||...::|.|
  Fly  1206 LEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDVELRKAIP----GLDYMVTERG 1266

  Fly  1189 SNFSVGQRQLVCLARAILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIM 1253
            .|||||||||:||||||||.|:|||:||||||||||||||||.|||.||:.|||||:||||:|:|
  Fly  1267 GNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVM 1331

  Fly  1254 DSDRVLVMDAGHLVEFGSPYELLTSSESKIFHGMVMETGQNTFDSLLKVAEKAHLESMKPKSE 1316
            ||||::|||||..|||..||.||..|:..: ..||..||..: ::|.|.|..:|....:.:.|
  Fly  1332 DSDRIIVMDAGVAVEFDVPYLLLKKSQGHL-RQMVEATGGES-EALKKTASDSHKRMQRERDE 1392

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	MRP_assoc_pro	13..1292	CDD:188098	606/1400 (43%)
Cftr	NP_651269.1	MRP_assoc_pro	12..1356	CDD:188098	603/1386 (44%)