Protein Alignment Mrp4 and abcc4

DIOPT Version :10

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: NP_001007039.2
• Gene: abcc4 / 368620
• ZFINID: ZDB-GENE-030616-511
• Length: 1331
• Species: Danio rerio
• Alignment Length: 1353
• Identity: 591/1353 - (43%)
• Similarity: 852/1353 - (62%)
• Gaps: 99/1353 - (7%)

  Fly     1 MQSMKADELPENPRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAW 65
            |:.:|.| ...||...::..|.:.||:..|:...|.|:.||:.|::..|.|.:|..||:.|.:.|
Zfish     5 MEPIKKD-AKSNPSASANLFSQIFFCWLNPLFSIGSKRRLEEDDMFNVLPEDRSKKLGEELQSYW 68

  Fly    66 D---EQVAKN-ETPRLGRALTKVFGFHLFITGVFLLAQEFLTKVTQPICLIGVMAYFAGNDPD-- 124
            |   |:.||. :||:|.:|:.:.:.....:.|||.|.:|.: ||.||:.|..::.||.....|
Zfish    69 DQEKEKAAKELKTPKLTKAIIRCYWKSYAVLGVFTLIEESI-KVIQPVFLGKLIKYFENYRHDDM 132

  Fly   125 --RSKAQLWAAGLIAGSVFSVCIGHPYMLGLLHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQ 187
              .|:|..:|.|:...::....:.|.|...:...|||:|||:..:||||||.||..|:|.||.||
Zfish   133 AALSEAYGYATGVCLSTLGLALLHHLYFYHVQRAGMKIRIAMCHMIYRKALCLSAAAMGQTTTGQ 197

  Fly   188 VVNLLSNDVGRFDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRT 252
            :||||||||.:||.:.|.:|:||:.||:..||..|::.|||.|.:.|:|:::..:|.|:..||..
Zfish   198 IVNLLSNDVNKFDELTIFLHFLWVGPLQAAAVIGLLWQEIGPSCLAGMAVLVFLMPLQTMFGKLF 262

  Fly   253 SVLRLRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGILISF 317
            |..|.:||..||.|:|.|||::|||::||||||||||..:|...|..|:..|...:|:||  ::.
Zfish   263 SKYRSKTAALTDSRIRTMNEVVSGIRIIKMYAWEKPFAMLVNDVRRKEISKIMSSSYLRG--LNM 325

  Fly   318 AMFLSRIFTSSSLIAF------VLLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVS 376
            |.|    ||::.:|.|      ||:||.::|.:.|...:.|:.:|.:||:|||..|.:.:|..:|
Zfish   326 ASF----FTANKIILFVTFTVYVLVGNTMSASRVFVAVSLYSAVRLTVTLFFPAAIEKVSESAIS 386

  Fly   377 VRRLEAFMHRPETKVRDKSKVKN----ANQKAESPNGDSPKGNGIPENLIEFSQFQARWESHSLE 437
            :||::.|:...|.       |||    :.::.:.|:             :|.......|:.....
Zfish   387 IRRIKKFLLLDEL-------VKNHLPLSQEEKKEPS-------------VEMQDLICYWDKTLDA 431

  Fly   438 PTLEDINLQLGRRKLVAVIGPVGAGKSSLIQAILGELPGESGTLRINGSYSYAAQEPWLFTGTVR 502
            |||:::...:...:|:|||||||||||||:..:|||||.|.|.:::.|..:||:|:||:|.||:|
Zfish   432 PTLQNVCFTVKPGQLLAVIGPVGAGKSSLLSTVLGELPAEKGVIKVKGELTYASQQPWVFPGTIR 496

  Fly   503 QNILFGLDWDKHRYRTVVKKCALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADI 567
            .|||||.:....||..|::.|||:||.||||.||.|::|:|||:||||||||::||||||:.|||
Zfish   497 SNILFGKELQPQRYERVLRACALKRDMELLPDGDLTVIGDRGATLSGGQKARVNLARAVYQDADI 561

  Fly   568 YLLDDPLSAVDTHVGRHLFDQCMRGYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSM 632
            |||||||||||..|.||||:||:.|.|:.:..||||||||:|:.|:.|:::.:|.:.|.|:||.:
Zfish   562 YLLDDPLSAVDAEVSRHLFEQCVCGILKDKPRILVTHQLQYLKAANQILVLKEGHMVARGSYSEL 626

  Fly   633 KRSGLDFAQLLTAPNKDAEDLDEIDGAGGDGLDLLNVPSLSRRGSKNSKPSTRNNSFTSLSSMAE 697
            ::|||||..||   .||.|:                 .|.|.:|.....|.:|..|..|:.|.:.
Zfish   627 QQSGLDFTSLL---KKDEEE-----------------ESGSEKGEAPRSPRSRTVSQNSVRSHSS 671

  Fly   698 SM-----------AQEASLQMQETRVEGKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSAA 751
            |:           |:......:|.|.||.||:.:|.:|..:|::..|:..::.|.|..|......
Zfish   672 SVLSVKDDSDQLPAEPVHTMAEELRSEGNIGIRMYWKYFRAGANVVMLVLLLLLNLLAQTFYILQ 736

  Fly   752 DYFLSYW------VDKNVDGQTDINTDPQDM-------YY---FAALNVAVVVFTIVRTMLFYKM 800
            |::||||      :|.|.:.....||...:.       :|   :|.|..|.:||..:|.::.:..
Zfish   737 DWWLSYWATEQEKLDHNTNNTNTNNTSAGNTTQQLDLNFYLGIYAGLTGATIVFGFMRCLIMFNA 801

  Fly   801 AMRSSTQLHNAMYQGITRAAMYFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGII 865
            .:.|:..|||.|:..|.|..:.||:.||.||||||||||:|.||.:||...:|.:|:||.::|:|
Zfish   802 LVSSAEMLHNRMFNSILRTPVRFFDINPIGRILNRFSKDIGHLDSLLPWTFVDFIQVFLQIVGVI 866

  Fly   866 VVICITNPYYLILTLALAIIFYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGA 930
            .|.....|:.||..|.|.|.|.::|.::|:|||||||:|:..|||::||||:::.||.||||..|
Zfish   867 AVASSVIPWILIPVLPLLICFLFLRRYFLRTSRDVKRIESTTRSPVFSHLSSSLQGLWTIRAFKA 931

  Fly   931 QKELIAEFDNLQDLHSSGYYTFLATNRAFGYYLDCFCTLYIVIIILN-YFINPPQSPGEVGLAIT 994
            ::.....||..|||||..::.||.|:|.|...||..|::::.|.... ..:....:.|:||||::
Zfish   932 EERFQQTFDAHQDLHSEAWFLFLTTSRWFAVRLDGMCSVFVTITAFGCLLLKDTMNAGDVGLALS 996

  Fly   995 QAMGMTGMVQWAMRQSAELENTMTAVERVVEYDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLC 1059
            .|:.:.||.||.:|||||:||.||:|||||||.|:|.|..::::  |:|||.||.:|.|..:.:.
Zfish   997 YAVTLMGMFQWGVRQSAEVENMMTSVERVVEYTELESEAPWETQ--KRPSPDWPNRGLITFDRVN 1059

  Fly  1060 LRYFPDPQAKYVLKALNFRIRPCEKVGIVGRTGAGKSSLINALFRLSYNEGIITIDERDTADMGL 1124
            ..|..|  ...|||.::...||.|||||||||||||||||:||||||..||.|.:|...|:::||
Zfish  1060 FSYSSD--GPVVLKNISAMFRPREKVGIVGRTGAGKSSLISALFRLSEPEGKILVDGVLTSEIGL 1122

  Fly  1125 FDLRSKISIIPQEPVLFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGS 1189
            .|||.|:|||||:||||:|:||.|||||.:::|..||.|||||:||..:.|||..|:::::|.||
Zfish  1123 HDLRQKMSIIPQDPVLFTGTMRKNLDPFNQHSDHDLWKALEEVQLKAAVEELPGKLETELAESGS 1187

  Fly  1190 NFSVGQRQLVCLARAILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMD 1254
            ||||||||||||||||||:||||::|||||||||:||.|||.|||.||::|||||||||||||:|
Zfish  1188 NFSVGQRQLVCLARAILRKNRVLIIDEATANVDPRTDELIQKTIRDKFKECTVLTIAHRLNTIID 1252

  Fly  1255 SDRVLVMDAGHLVEFGSPYELLTSSESKIFHGMVMETGQNTFDSLLKVAEKAH 1307
            |||:||:|||.:.|:.:|:.|| .::|.||:.||.:||:....|||:.|::|:
Zfish  1253 SDRILVLDAGRIHEYDAPHVLL-QNQSGIFYKMVQQTGKAEATSLLQTAKQAY 1304

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	MRP_assoc_pro	13..1292	CDD:188098	580/1324 (44%)
abcc4	NP_001007039.2	MRP_assoc_pro	11..1289	CDD:188098	582/1330 (44%)