Protein Alignment Mrp4 and abcc5

DIOPT Version :10

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: NP_001182542.1
• Gene: abcc5 / 336147
• ZFINID: ZDB-GENE-050517-17
• Length: 1426
• Species: Danio rerio
• Alignment Length: 1398
• Identity: 454/1398 - (32%)
• Similarity: 729/1398 - (52%)
• Gaps: 171/1398 - (12%)

  Fly     6 ADELPENPRERS---------SPLSSL-----------MFCF-------ALPVLFKGRKKTLEQK 43
            |.||.|:...||         .|:.|.           :|.|       :|.|| ..:|..|..:
Zfish    63 AKELEEDAAGRSKYHHSVCVLKPIRSTSKYQHPVDNAGLFSFMTFNWLTSLAVL-AHKKGQLFLE 126

  Fly    44 DLYRALKEHKSDSLG-DRLCAAWDEQV-AKNETPRLGRALTKVFGFHLFITGVFLLAQEFLTKVT 106
            |:: |:.:.:|..:. .||...|:|:: ::.....|.|.:.......|.::.:.|:..: |...:
Zfish   127 DIW-AVSQFESCEINRRRLAGLWEEEIRSRGNDASLRRVVWHFCRTRLLLSILCLMVTQ-LAGFS 189

  Fly   107 QPICLI-GVMAYFAGNDPDRSKAQLWAAGLIAGSVFSVCIGHPYMLGL-LHLGMKMRIALSSLIY 169
            .|..:: .::.|...::||.....|...||:|..:.. ...|.....| ...|.::|.|:.::.:
Zfish   190 SPAFVVWRLLEYTQRSEPDLPYGLLLVLGLLATELIR-SWSHALTWALNYRTGTRLRGAILTMAF 253

  Fly   170 RKALRLSRTALGDTTVGQVVNLLSNDVGR-FDLVLINVHYLWIAPLELIAVTYLMY--LEIGISS 231
            .|.|||  .:|.:.::|:::|:.|.|..| |:...:.   ..:|...|:||..:.|  ..:|.:|
Zfish   254 HKILRL--RSLREKSMGELINMCSGDGQRMFEAAAVG---SLLAGGPLVAVLGMAYNLFVLGPTS 313

  Fly   232 MFGVAIMLLFLPFQSYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMT 296
            :.|.|:.:||.|...:..:.|:..|.:....||:||:.||||::.|:.||||||.|.|.:.|...
Zfish   314 LLGSAVFILFYPTMMFSSRLTAYFRRKGVAVTDQRVQKMNEILNYIKFIKMYAWVKAFSQAVRRI 378

  Fly   297 RFNEMLCIKQVNYIRGILISFAMFLSRIFTSSSLIAFVLLGNILNAEKAFFVTAYYNILRRSVTM 361
            |..|...:::..|.:.|.:..|..:..|.:.::....:|||..|.|.:||.|...:|.:..::.:
Zfish   379 RDEERQILERTGYFQSITVGVAPIVVVIASVATFSTHMLLGYDLTAAQAFTVVTVFNAMTFALKV 443

  Fly   362 FFPQGISEFAELLVSVRRLEAFMHRPETKV-----RDKS---KVKNANQKAE--------SPNG- 409
             .|..:...:|..|::.|.::.:...|.|:     |:.|   ::..|:...|        ||.|
Zfish   444 -TPFSVKSLSEASVAIDRFKSLLLMAEVKMIRELPRNPSVAVEMSGASLAWETGGHSAQPSPRGT 507

  Fly   410 ---------------DSPKGNGIPEN------LIEFSQFQARWE----------SHSLEPTLEDI 443
                           |.||.:.|.|.      |.:.|...|...          |..|:.||..|
Zfish   508 PHVGTRGCRKKRRQRDVPKHHAILEEETHGQLLNDVSGEMASSPKDQTLHVPTISQRLQRTLHCI 572

  Fly   444 NLQLGRRKLVAVIGPVGAGKSSLIQAILGELPGESGTLRINGSYSYAAQEPWLFTGTVRQNILFG 508
            :|.:.:.|||.|.|.||:||:|||.||||::....||:.::|.::|.||:.|:...:.|.|||||
Zfish   573 DLSIQKGKLVGVCGSVGSGKTSLISAILGQMTLLEGTVAVDGDFAYVAQQAWILNASFRDNILFG 637

  Fly   509 LDWDKHRYRTVVKKCALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDP 573
            .:.::.||:.::..|.|..|..:||.||.|.:|||||:|||||:.|||||||:|....||:||||
Zfish   638 KEMEEERYQAILSACCLRPDLAMLPSGDLTEIGERGANLSGGQRQRISLARALYSNRGIYILDDP 702

  Fly   574 LSAVDTHVGRHLFDQCMRGYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRSGLD 638
            |||:|.|||.|:|:..::..||.:.||.||||||:|...|.:::|..|.|:..|::..:.....|
Zfish   703 LSALDAHVGNHIFNNAIKKQLRGKTVIFVTHQLQYLVDCDDVIVMRDGSIAEQGSHEDLMNVNGD 767

  Fly   639 FA------QLLTAPNKDAEDLDEIDGAGGDGLDLLNVPSLSRRGSKNSKPSTRNNSFTSLSSMAE 697
            :|      ||...|                   ::.||: .:.||...||..:        |.|.
Zfish   768 YAAMFNNLQLGETP-------------------IIEVPN-KKSGSSLKKPLEK--------SKAG 804

  Fly   698 SMAQEAS-------LQMQETRVEGKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSAADYFL 755
            |:.:|.|       |...|.|.:|.:...:||.|:.:...|.:..|::.|.:......:.::::|
Zfish   805 SVKKEKSTTQGDGQLMQVEERGKGSVPWAVYKVYIQALGGWPVFLFILALFILNVGSTAFSNWWL 869

  Fly   756 SYWVDKNVDGQTDINT-----------DPQDMYYFAALNV----AVVVFTIVRTMLFYKMAMRSS 805
            .||: |...|.|.:..           |...|.::||:..    .:::..::|.::|.|..:|:|
Zfish   870 CYWI-KQGSGNTTVQVGNSSVLSESMRDNPLMQHYAAVYTMSMGVMLLLKLLRGIVFVKGTLRAS 933

  Fly   806 TQLHNAMYQGITRAAMYFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICI 870
            ::||:.::|.|.|:.|.||:|.|:.|||||||||:.::|..||.......|..:.:|..:.||..
Zfish   934 SRLHDELFQKILRSPMKFFDTTPTARILNRFSKDMDEVDTRLPFQAEMFTQNVILVLFCLAVIGS 998

  Fly   871 TNPYYLILTLALAIIFYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELI 935
            ..|::|:....|.::|..:........|::|||:.|.:||..||::::|.||.|:.|.|.:.|.:
Zfish   999 VFPWFLVAVGPLVLLFTVLHVVSRVFIRELKRLDNVTQSPFLSHIASSIQGLTTVHAYGKEDEFL 1063

  Fly   936 AEFDNLQDLHSSGYYTFLATNRAFGYYLDCFCTLYIVIIILNYFINPPQ-SPGEVGLAITQAMGM 999
            ..:..|.|.:.:.:|.|....|.....||......|.|..|...:...| .|...||||:.|:.:
Zfish  1064 HRYQELLDQNQAPFYLFSCAMRWLAVRLDVISVALISITALMIVLMHGQIPPAYAGLAISYAVQL 1128

  Fly  1000 TGMVQWAMRQSAELENTMTAVERVVEYDE---IEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLR 1061
            ||:.|:.:|.::|.|...|:|||:..|.:   :|.....   :.|.|...||::|||:
Zfish  1129 TGLFQFTVRLASETEARFTSVERIHHYIKSLSLEAPARV---KNKAPPSDWPQEGEIV------- 1183

  Fly  1062 YFPDPQAKY------VLKALNFRIRPCEKVGIVGRTGAGKSSLINALFRL-SYNEGIITIDERDT 1119
             |...:.||      :||..:|.:||.||:|||||||:|||||...|:|| ....|.|.||..:.
Zfish  1184 -FDQTEMKYRDNLPLILKKASFTVRPKEKIGIVGRTGSGKSSLGVVLYRLVEPCGGSIKIDGVNI 1247

  Fly  1120 ADMGLFDLRSKISIIPQEPVLFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKI 1184
            .|:||.|:|||:||||||||||||::|.|||||.:|::|::|||||...:|..:|:||..|:|::
Zfish  1248 CDIGLADVRSKLSIIPQEPVLFSGTVRSNLDPFSQYSEAQIWDALERTHMKECVSQLPLKLESEV 1312

  Fly  1185 SEGGSNFSVGQRQLVCLARAILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRL 1249
            .|.|.|||||:|||:|:||.:||:.::|::|||||.:..:||.|||.|||:.|:|||.||||||:
Zfish  1313 VENGENFSVGERQLLCVARVLLRQCKILILDEATAAMGTETDCLIQETIRNAFQDCTTLTIAHRV 1377

  Fly  1250 NTIMDSDRVLVMDAGHLVEFGSPYELLTSSESK 1282
            :|::..||::|::.|.:|||..|.:||.:..|:
Zfish  1378 HTVLSCDRIMVLNQGQVVEFDEPSKLLANENSR 1410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	MRP_assoc_pro	13..1292	CDD:188098	450/1391 (32%)
abcc5	NP_001182542.1	intraplasmic N-terminal	1..59
		transmembrane domain 1	59..149		20/87 (23%)
		MRP_assoc_pro	95..1405	CDD:188098	444/1359 (33%)
		nucleotide binding domain 1	188..248		12/60 (20%)
		transmembrane domain 2	279..379		34/102 (33%)
		nucleotide binding domain 2	403..450		11/47 (23%)