Protein Alignment Mrp4 and Abcc5

DIOPT Version :10

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: NP_038818.2
• Gene: Abcc5 / 27416
• MGIID: 1351644
• Length: 1436
• Species: Mus musculus
• Alignment Length: 1392
• Identity: 446/1392 - (32%)
• Similarity: 732/1392 - (52%)
• Gaps: 151/1392 - (10%)

  Fly    11 ENPRERSSPLSSLMFCFALPVLFKGRKK-TLEQKDLYRALKEHKSDSLGDRLCAAWDEQVAKNET 74
            ::|.:.:...|.:.|.:..|:.....|| .|..:|::...|...||....||...|.|::  ||.
Mouse    98 QHPVDNAGLFSYMTFSWLSPLARVVHKKGELLMEDVWPLSKYESSDVNSRRLERLWQEEL--NEV 160

  Fly    75 PRLGRALTKVFGF----HLFITGVFLLAQEFLTKVTQPICLI-GVMAYFAGNDPDRSKAQLWAAG 134
            .....:|.:|...    .|.::.|.|:..: |...:.|..:: .::.|....:.:...:.|...|
Mouse   161 GPDAASLRRVVWIFCRTRLILSIVCLMITQ-LAGFSGPAFVVKHLLEYTQATESNLQYSLLLVLG 224

  Fly   135 LIAGSVFSVCIGHPYMLGL-----LHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLLSN 194
            |:...|.     ..:.|.|     ...|:::|.|:.::.::|.|:|..  :.:.::|:::|:.||
Mouse   225 LLLTEVV-----RSWSLALTWALNYRTGVRLRGAILTMAFKKILKLKN--IKEKSLGELINICSN 282

  Fly   195 DVGR-FDLVLINVHYLWIAPLELIAVTYLMY--LEIGISSMFGVAIMLLFLPFQSYLGKRTSVLR 256
            |..| |:...:.   ..:|...::|:..::|  :.:|.:...|.|:.:||.|...::.:.|:..|
Mouse   283 DGQRMFEAAAVG---SLLAGGPVVAILGMIYNVIILGPTGFLGSAVFILFYPAMMFVSRLTAYFR 344

  Fly   257 LRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGILISFAMFL 321
            .:....||:||:.|||:::.|:.||||||.|.|.:.|:..|..|...:::..|.:.|.:..|..:
Mouse   345 RKCVAATDDRVQKMNEVLTYIKFIKMYAWVKAFSQCVQKIREEERRILEKAGYFQSITVGVAPIV 409

  Fly   322 SRIFTSSSLIAFVLLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAF--- 383
            ..|.:..:....:.||..|.|.:||.|...:|.:..::.: .|..:...:|..|:|.|.::.
Mouse   410 VVIASVVTFSVHMTLGFHLTAAQAFTVVTVFNSMTFALKV-TPFSVKSLSEASVAVDRFKSLFLM 473

  Fly   384 --MHRPETKVRD---KSKVKNANQKAESPNG---DSPK-------------GNGIPENLIEFSQF 427
              :|..:.|...   |.::|||....:|.:.   :|||             |.......::.::.
Mouse   474 EEVHMIKNKPASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKMKKDKRATRGKKEKSRQLQHTEH 538

  Fly   428 Q---ARWESH------------------------SLEPTLEDINLQLGRRKLVAVIGPVGAGKSS 465
            |   |..:.|                        .|:.||.:|:|::...|||.:.|.||:||:|
Mouse   539 QAVLAEQKGHLLLDSDERPSPEEEEGKQIHTGSLRLQRTLYNIDLEIEEGKLVGICGSVGSGKTS 603

  Fly   466 LIQAILGELPGESGTLRINGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCALERDFE 530
            |:.||||::....|::.::|:::|.||:.|:...|:|.|||||.::|:.||.:|:..|.|..|..
Mouse   604 LVSAILGQMTLLEGSIAVSGTFAYVAQQAWILNATLRDNILFGKEFDEERYNSVLNSCCLRPDLA 668

  Fly   531 LLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFDQCMRGYLR 595
            :||..|.|.:|||||:|||||:.|||||||:|....||:|||||||:|.|||.|:|:..:|..|:
Mouse   669 ILPNSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKRLK 733

  Fly   596 SELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRSGLDFAQLLT------APNKDAEDLD 654
            |:.|:.||||||:|...|.::.|.:|.|:..||:..:.....|:|.:..      .|..:.....
Mouse   734 SKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGETPPVEINSKK 798

  Fly   655 EIDGAGGDGLDLLNVPSLSRRGSKNSKPSTRNNSFTSLSSMAESMAQEASLQMQETRVEGKIGLG 719
            |..|:             .:...|..||.       |:.......::|..|...|.:.:|.:...
Mouse   799 EATGS-------------QKSQDKGPKPG-------SVKKEKAVKSEEGQLVQVEEKGQGSVPWS 843

  Fly   720 LYKEYL--TSGSSWFMIFFMVFLCLATQILCSAADYFLSYWVDKNVDGQT----------DINTD 772
            :|..|:  ..|...|::..::|:........|.  ::||||:.:.....|          |...|
Mouse   844 VYWVYIQAAGGPLAFLVIMVLFMLNVGSTAFST--WWLSYWIKQGSGNSTVYQGNRSFVSDSMKD 906

  Fly   773 PQDMYYFA---ALNVAV-VVFTIVRTMLFYKMAMRSSTQLHNAMYQGITRAAMYFFNTNPSGRIL 833
            ...|.|:|   ||::|| ::...:|.::|.|..:|:|::||:.:::.|.|:.|.||:|.|:||||
Mouse   907 NPFMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRIL 971

  Fly   834 NRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICI-----TNPYYLILTLALAIIFYYIREFY 893
            ||||||:.::|..||.    ..::|:..: |:|..|:     ..|::|:....|.|:|..:....
Mouse   972 NRFSKDMDEVDVRLPF----QAEMFIQNV-ILVFFCVGMIAGVFPWFLVAVGPLLILFSLLHIVS 1031

  Fly   894 LKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSSGYYTFLATNRA 958
            ....|::|||:.:.:||..||::::|.||.||.|...::|.:..:..|.|.:.:.::.|....|.
Mouse  1032 RVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKRQEFLHRYQELLDDNQAPFFLFTCAMRW 1096

  Fly   959 FGYYLDCFCTLYIVIIILNYFINPPQSPGE-VGLAITQAMGMTGMVQWAMRQSAELENTMTAVER 1022
            ....||......|....|...:...|.|.. .||||:.|:.:||:.|:.:|.::|.|...|:|||
Mouse  1097 LAVRLDLISIALITTTGLMIVLMHGQIPSAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVER 1161

  Fly  1023 VVEYDE---IEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYVLKALNFRIRPCEK 1084
            :..|.:   :|.....   :.|.|...||::||:..|:..:||  ......|||.::|.|:|.||
Mouse  1162 INHYIKTLSLEAPARI---KNKAPPHDWPQEGEVTFENAEMRY--RENLPLVLKKVSFTIKPKEK 1221

  Fly  1085 VGIVGRTGAGKSSLINALFRL-SYNEGIITIDERDTADMGLFDLRSKISIIPQEPVLFSGSMRYN 1148
            :|||||||:|||||..||||| ..:.|.|.||....:|:||.|||||::|||||||||||::|.|
Mouse  1222 IGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGIRISDIGLADLRSKLAIIPQEPVLFSGTVRSN 1286

  Fly  1149 LDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARAILRENRVLV 1213
            ||||.:|.:.::|||||...:|..|::||..|:|::.|.|.|||||:|||:|:|||:||..::|:
Mouse  1287 LDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILI 1351

  Fly  1214 MDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYELLTS 1278
            :|||||.:|.:||.|||.|||..|.|||:|||||||:|::.|||::|:..|.:|||.:| .:|.|
Mouse  1352 LDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTP-SVLLS 1415

  Fly  1279 SESKIFHGMVMETGQNTFDSLLKVAEK 1305
            ::|..|:.| ....:|      |||.|
Mouse  1416 NDSSRFYAM-FAAAEN------KVAVK 1435

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	MRP_assoc_pro	13..1292	CDD:188098	441/1375 (32%)
Abcc5	NP_038818.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..41
		PLN03130	100..1424	CDD:215595	440/1370 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	501..569		8/67 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	798..822		6/43 (14%)