Protein Alignment Mrp4 and Abcc2

DIOPT Version :10

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: NP_036965.1
• Gene: Abcc2 / 25303
• RGDID: 2366
• Length: 1541
• Species: Rattus norvegicus
• Alignment Length: 1389
• Identity: 475/1389 - (34%)
• Similarity: 747/1389 - (53%)
• Gaps: 154/1389 - (11%)

  Fly    11 ENPRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAWDEQVAK---- 71
            :.|...:|.|||:.|.:....:.||.|..|..:|::...:..|:.|:..:..||..:.:.|
  Rat   191 QTPSVTASFLSSITFSWYDRTVLKGYKHPLTLEDVWDIDEGFKTRSVTSKFEAAMTKDLQKARQA 255

  Fly    72 --------------------------------NETPRLGRALTKVFGFHLFITGVF-----LLAQ 99
                                            .|..:.....||.:.....|..:|     ::.:
  Rat   256 FQRRLQKSQRKPEATLHGLNKKQSQSQDVLVLEEAKKKSEKTTKDYPKSWLIKSLFKTFHVVILK 320

  Fly   100 EFLTKVTQPI----------CLIGVMAYFAGNDPDRSKAQLWAAGLIAGSVFSV------CIGHP 148
            .|:.|:...:          .|||.:        ..|.:.:|...:.|..:|:|      |: ..
  Rat   321 SFILKLIHDLLVFLNPQLLKLLIGFV--------KSSNSYVWFGYICAILMFAVTLIQSFCL-QS 376

  Fly   149 YMLGLLHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLLSNDVGRFDLVLINVHYLWIAP 213
            |......|||.:|..:.|.||:|||.||..|....|:|:.|||:|.|..:.......:..:|.:.
  Rat   377 YFQHCFVLGMCVRTTVMSSIYKKALTLSNLARKQYTIGETVNLMSVDSQKLMDATNYMQLVWSSV 441

  Fly   214 LELIAVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVLRLRTALRTDERVRMMNEIISGIQ 278
            :::....:.::.|:|.|.:.||.:|:|.:|....|..:...::::.....|:|:::||||:|||:
  Rat   442 IQITLSIFFLWRELGPSILAGVGVMVLLIPVNGVLATKIRNIQVQNMKNKDKRLKIMNEILSGIK 506

  Fly   279 VIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGILISFAMFLSRIFTS---SSLIAFVLLGNIL 340
            ::|.:|||..|.:.|:..|..|:..:.:...::.:|| |.:.::.|..|   .|:...|...|:|
  Rat   507 ILKYFAWEPSFQEQVQGIRKKELKNLLRFGQLQSLLI-FILQITPILVSVVTFSVYVLVDSANVL 570

  Fly   341 NAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAFMHRPETKVRDKSKVKNANQKAE 405
            ||||||.....:||||..::| .|...|...:..|||.|||.::...:.......:|.|.
  Rat   571 NAEKAFTSITLFNILRFPLSM-LPMVTSSILQASVSVDRLERYLGGDDLDTSAIRRVSNF----- 629

  Fly   406 SPNGDSPKGNGIPENLIEFSQFQARWESHSLEPTLEDINLQLGRRKLVAVIGPVGAGKSSLIQAI 470
                         :..::||:....|:. .||.|::|:||.:...:||||:|.||:|||||:.|:
  Rat   630 -------------DKAVKFSEASFTWDP-DLEATIQDVNLDIKPGQLVAVVGTVGSGKSSLVSAM 680

  Fly   471 LGELPGESGTLRINGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCALERDFELLPFG 535
            |||:....|.:.|.||.:|..|:.|:..||::.|||||.::::.:|:.|:|.|||..|.|:||.|
  Rat   681 LGEMENVHGHITIQGSTAYVPQQSWIQNGTIKDNILFGSEYNEKKYQQVLKACALLPDLEILPGG 745

  Fly   536 DKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFDQCM--RGYLRSEL 598
            |...:||:|.:||||||.|:|||||.|:.||||:|||||||||.|||:|:|::.:  .|.|..:.
  Rat   746 DMAEIGEKGINLSGGQKQRVSLARAAYQDADIYILDDPLSAVDAHVGKHIFNKVVGPNGLLAGKT 810

  Fly   599 VILVTHQLQFLEQADLIVIMDKGRISAMGTY---------------SSMKRSGLDFAQLLTAPNK 648
            .|.|||.:.||.|.|.||::.||.|...|:|               :.||.||.:....:   |.
  Rat   811 RIFVTHGIHFLPQVDEIVVLGKGTILEKGSYRDLLDKKGVFARNWKTFMKHSGPEGEATV---NN 872

  Fly   649 DAEDLDEIDG---------AGGDGLDLLNVPSLSRRGSKNSKPSTR-----NNSF----TSLSSM 695
            |:|..|:.||         .....|.:....||.|..|::|:.|:|     .||.    .::...
  Rat   873 DSEAEDDDDGLIPTMEEIPEDAASLAMRRENSLRRTLSRSSRSSSRRGKSLKNSLKIKNVNVLKE 937

  Fly   696 AESMAQEASLQMQETRVEGKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSAADYFLSYWV- 759
            .|...:...|..:|....||:...:|.:||.:...|.::|.::|..| ..:....::.:||.|.
  Rat   938 KEKEVEGQKLIKKEFVETGKVKFSIYLKYLQAVGWWSILFIILFYGL-NNVAFIGSNLWLSAWTS 1001

  Fly   760 -DKNVDGQTDINTDPQDMY--YFAALNVAVVVFTIVRTMLFYKMAMRSSTQLHNAMYQGITRAAM 821
             ..|::| |:.::..:||.  .|.||.:|..:..::.|:........:|..||..:...|.||.|
  Rat  1002 DSDNLNG-TNNSSSHRDMRIGVFGALGLAQGICLLISTLWSIYACRNASKALHGQLLTNILRAPM 1065

  Fly   822 YFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLILTLALAIIF 886
            .||:|.|:|||:||||.|:..:|::||..:...:..|..:.|.:|:||:..|.:.|:.:.|:|::
  Rat  1066 RFFDTTPTGRIVNRFSGDISTVDDLLPQTLRSWMMCFFGIAGTLVMICMATPVFAIIIIPLSILY 1130

  Fly   887 YYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSSGYYT 951
            ..::.||:.|||.::||::|.:||||||.|.|:||||.|||...|:..:|..:...|::....::
  Rat  1131 ISVQVFYVATSRQLRRLDSVTKSPIYSHFSETVTGLPIIRAFEHQQRFLAWNEKQIDINQKCVFS 1195

  Fly   952 FLATNRAFGYYLD------CFCTLYIVIIILNYFINPPQSPGE-VGLAITQAMGMTGMVQWAMRQ 1009
            ::.:||.....|:      .||:..:::|.....      .|: ||..::.|:.:|..:.|.:|.
  Rat  1196 WITSNRWLAIRLELVGNLVVFCSALLLVIYRKTL------TGDVVGFVLSNALNITQTLNWLVRM 1254

  Fly  1010 SAELENTMTAVERVVEYDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYVLKA 1074
            ::|.|..:.||||:.||..:|.|..:.:  .|:|...||..|||...:..:||  .|:...|||.
  Rat  1255 TSEAETNIVAVERISEYINVENEAPWVT--DKRPPADWPRHGEIQFNNYQVRY--RPELDLVLKG 1315

  Fly  1075 LNFRIRPCEKVGIVGRTGAGKSSLINALFR-LSYNEGIITIDERDTADMGLFDLRSKISIIPQEP 1138
            :...|:..||||:|||||||||||.|.||| |....|.|.||..|.|.:||.|||.:::||||:|
  Rat  1316 ITCNIKSGEKVGVVGRTGAGKSSLTNCLFRILESAGGQIIIDGIDVASIGLHDLRERLTIIPQDP 1380

  Fly  1139 VLFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLAR 1203
            :|||||:|.|||||.:|:|.::|.|||...|:..:|.|..||.|:::|||.|.|:|||||:||.|
  Rat  1381 ILFSGSLRMNLDPFNKYSDEEVWRALELAHLRSFVSGLQLGLLSEVTEGGDNLSIGQRQLLCLGR 1445

  Fly  1204 AILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVE 1268
            |:||::::||:|||||.||.:||:|||.|||.:|..|||:||||||:||||||:::|:|.|.:||
  Rat  1446 AVLRKSKILVLDEATAAVDLETDSLIQTTIRKEFSQCTVITIAHRLHTIMDSDKIMVLDNGKIVE 1510

  Fly  1269 FGSPYELLTSSESKIFHGMVMETG 1292
            :|||.|||::..|  |:.|..|.|
  Rat  1511 YGSPEELLSNRGS--FYLMAKEAG 1532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	MRP_assoc_pro	13..1292	CDD:188098	474/1385 (34%)
Abcc2	NP_036965.1	MRP_assoc_pro	7..1533	CDD:188098	475/1389 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	862..881		6/21 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	901..923		7/21 (33%)