Protein Alignment Mrp4 and Abcc4

DIOPT Version :10

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: NP_001028508.2
• Gene: Abcc4 / 239273
• MGIID: 2443111
• Length: 1325
• Species: Mus musculus
• Alignment Length: 1341
• Identity: 584/1341 - (43%)
• Similarity: 850/1341 - (63%)
• Gaps: 84/1341 - (6%)

  Fly     8 ELPENPRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAWDEQV--A 70
            |:..||.:.::..|.:.|.:..|:...|.|:.||:.|::..|.|.:|..||:.|...||:::  |
Mouse     7 EVKPNPLQDANLCSRVFFWWLNPLFKTGHKRRLEEDDMFSVLPEDRSKHLGEELQRYWDKELLRA 71

  Fly    71 KNET--PRLGRALTKVFGFHLFITGVFLLAQEFLTKVTQPICLIGVMAYFAGNDPDRSKAQLWAA 133
            |.::  |.|.:|:.|.:.....|.|:|.|.:|. |:|.||:.|..::.||...|||.|.|...|.
Mouse    72 KKDSRKPSLTKAIIKCYWKSYLILGIFTLIEEG-TRVVQPLFLGKIIEYFEKYDPDDSVALHTAY 135

  Fly   134 GLIAGSVFSVC------IGHPYMLGLLHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLL 192
            |..|  |.|:|      :.|.|...:...||::|:|:..:|||||||||.:|:|.||.||:||||
Mouse   136 GYAA--VLSMCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNSAMGKTTTGQIVNLL 198

  Fly   193 SNDVGRFDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVLRL 257
            ||||.:||.|.|.:|:||..||:.||||.|:::|||||.:.|:|::::.||.||.:||..|.||.
Mouse   199 SNDVNKFDQVTIFLHFLWAGPLQAIAVTVLLWVEIGISCLAGLAVLVILLPLQSCIGKLFSSLRS 263

  Fly   258 RTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGILISFAMFLS 322
            :||..||.|:|.|||:|:|:::||||||||.|..::...|..|:..|...:|:||:.::.....:
Mouse   264 KTAAFTDARIRTMNEVITGMRIIKMYAWEKSFADLIANLRKKEISKILGSSYLRGMNMASFFIAN 328

  Fly   323 RIFTSSSLIAFVLLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAFMHRP 387
            ::....:..::|||||.:.|...|.....|..:|.:||:|||..|...:|.:||:||::.|:...
Mouse   329 KVILFVTFTSYVLLGNEITASHVFVAMTLYGAVRLTVTLFFPSAIERGSEAIVSIRRIKNFLLLD 393

  Fly   388 ETKVRDKSKVKNANQKAESPNGDSPKGNGIPENLIEFSQFQARWESHSLEPTLEDINLQLGRRKL 452
            |...|          ||..|:    .|..|    :....|.|.|:.....|||:.::......:|
Mouse   394 ELPQR----------KAHVPS----DGKAI----VHVQDFTAFWDKALDSPTLQGLSFIARPGEL 440

  Fly   453 VAVIGPVGAGKSSLIQAILGELPGESGTLRINGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYR 517
            :||:||||||||||:.|:|||||..||.:.::|..:|.:|:||:|:||||.|||||..::|.||.
Mouse   441 LAVVGPVGAGKSSLLSAVLGELPPASGLVSVHGRIAYVSQQPWVFSGTVRSNILFGKKYEKERYE 505

  Fly   518 TVVKKCALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVG 582
            .|:|.|||::|.:||..||.|::|:|||:||||||||::||||||:.||||||||||||||..||
Mouse   506 KVIKACALKKDLQLLEDGDLTVIGDRGATLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVG 570

  Fly   583 RHLFDQCMRGYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRSGLDFAQLLTAPN 647
            :|||..|:...|..::.||||||||:|:.|..|:|:..|.:...|||:...:||:||..||...|
Mouse   571 KHLFQLCICQALHEKITILVTHQLQYLKAASHILILKDGEMVQKGTYTEFLKSGVDFGSLLKKEN 635

  Fly   648 KDAEDLDEIDGAGGDGLDLLNVPSLSRR--------GSKNSKPSTRNNSFTSLSSMAESMAQEAS 704
            ::||.    ..|.|       .|:|.:|        ..::|:||.::.     :...:......:
Mouse   636 EEAEP----STAPG-------TPTLRKRTFSEASIWSQQSSRPSLKDG-----APEGQDAENTQA 684

  Fly   705 LQMQETRVEGKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSAADYFLSYWVDK-------- 761
            :|.:|:|.||:||...||.|.::|:|||.|.|:|.|.:..|:.....|::||:|.:|
Mouse   685 VQPEESRSEGRIGFKAYKNYFSAGASWFFIIFLVLLNMVGQVFYVLQDWWLSHWANKQGALNNTR 749

  Fly   762 NVDGQTDINTDPQDMYY----FAALNVAVVVFTIVRTMLFYKMAMRSSTQLHNAMYQGITRAAMY 822
            |.:|..   |:..|:.:    :|.|....|:|.|.|::|.:.:.:.:|..|||.|::.|.:|.:.
Mouse   750 NANGNI---TETLDLSWYLGIYAGLTAVTVLFGIARSLLVFYILVNASQTLHNRMFESILKAPVL 811

  Fly   823 FFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLILTLALAIIFY 887
            ||:.||.||||||||||:|.:|::||...||.:|..|.::.:|.|.....|:.||..:.|:::|.
Mouse   812 FFDRNPIGRILNRFSKDIGHMDDLLPLTFLDFIQTLLLVVSVIAVAAAVIPWILIPLVPLSVVFL 876

  Fly   888 YIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSSGYYTF 952
            .:|.::|:|||||||||:..|||::||||:::.||.||||..|::.....||..|||||..::.|
Mouse   877 VLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLF 941

  Fly   953 LATNRAFGYYLDCFCTLYIVII-----ILNYFINPPQSPGEVGLAITQAMGMTGMVQWAMRQSAE 1012
            |.|:|.|...||..|.::::::     :|...:|    .|:||||::.|:.:.||.||::|||||
Mouse   942 LTTSRWFAVRLDAICAIFVIVVAFGSLVLAKTLN----AGQVGLALSYALTLMGMFQWSVRQSAE 1002

  Fly  1013 LENTMTAVERVVEYDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYVLKALNF 1077
            :||.|.:||||:||.::|.|..::.:  |:|.|.||.:|.|:.:::...|..|  ...|||.|..
Mouse  1003 VENMMISVERVIEYTDLEKEAPWECK--KRPPPGWPHEGVIVFDNVNFTYSLD--GPLVLKHLTA 1063

  Fly  1078 RIRPCEKVGIVGRTGAGKSSLINALFRLSYNEGIITIDERDTADMGLFDLRSKISIIPQEPVLFS 1142
            .|:..|||||||||||||||||:||||||..||.|.||:..|.::||.|||.|:||||||||||:
Mouse  1064 LIKSREKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFT 1128

  Fly  1143 GSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARAILR 1207
            |:||.|||||.|:.|.:||.|||||:||..|.:||..:.::::|.|||||||||||||||||||:
Mouse  1129 GTMRKNLDPFNEHTDEELWRALEEVQLKEAIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILK 1193

  Fly  1208 ENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSP 1272
            .||:|::|||||||||:||.|||..||.||..|||||||||||||:|||:::|:|:|.|.|:..|
Mouse  1194 NNRILIIDEATANVDPRTDELIQQKIREKFAQCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEP 1258

  Fly  1273 YELLTSSESKIFHGMVMETGQNTFDSLLKVAEKAHLESMKP 1313
            |.||.:.|| :|:.||.:.|:....:|.:.|::.:.....|
Mouse  1259 YVLLQNPES-LFYKMVQQLGKGEAAALTETAKQVYFRRNYP 1298

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	MRP_assoc_pro	13..1292	CDD:188098	578/1313 (44%)
Abcc4	NP_001028508.2	PLN03130	12..1284	CDD:215595	579/1320 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	657..690		4/37 (11%)
		PDZ-binding. /evidence=ECO:0000250|UniProtKB:O15439	1322..1325