Protein Alignment Mrp4 and mrp-5

DIOPT Version :10

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: NP_510479.1
• Gene: mrp-5 / 181587
• WormBaseID: WBGene00003411
• Length: 1427
• Species: Caenorhabditis elegans
• Alignment Length: 1373
• Identity: 427/1373 - (31%)
• Similarity: 683/1373 - (49%)
• Gaps: 152/1373 - (11%)

  Fly    21 SSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLG---DRLCAAW-DEQVAKNETPRLGRAL 81
            |.:.:.:..|.|::..:..|::..::..   ...||.|   .||...| ||:.|..::|.|.:.:
 Worm    77 SFVTYSWVFPYLYQAVRGKLDRNQVWGC---SFYDSCGLNMARLEVLWEDEKKANAKSPSLFKVI 138

  Fly    82 TKVFGFHL-FITGVFLLAQEFLTKVTQPICLIGVMAYFAGNDPDRSKAQ--LWAAGLIAGSVFSV 143
            .:.....| |...||.....|  ....|.|.|..:..||.| |:|.:..  :::.|:...:..||
 Worm   139 YRFISTRLWFSCAVFFFCLIF--GFIGPTCFIRRLIAFAEN-PERDEQSRIVYSYGIALVAAISV 200

  Fly   144 -------CIGHPYMLGLLHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLLSNDVGR-FD 200
                   ..|..:.:. ...|:::|.|:.:|:|:..|. |:...|.|. ..|:|:.:||..| ||
 Worm   201 VEFARVLSYGATWAVS-YRTGIRVRGAVLALLYKNVLN-SKDLCGKTE-SDVINIFANDGQRLFD 262

  Fly   201 LVLINVHYLWIAPLELI-AVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVLRLRTALRTD 264
            .|.. ...:.:.||.|: .:.||: :.||..|:.|:.:..:|...|..|||.....|....::|:
 Worm   263 AVTF-APLVLVGPLVLVGGIGYLL-MVIGRWSLLGILVFFVFDVIQFGLGKSMVACRNLAIVKTE 325

  Fly   265 ERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGILISFAMFLSRIFTSSS 329
            :|:.||.|||..|:::||..||:.|...::..|..|.:.|::..|.:.:.|:....:..:....:
 Worm   326 KRISMMAEIIKYIRIVKMNGWEQIFSAKIDQFRKEEKVQIRKSGYAQSLAIACGPVVPVVAAILT 390

  Fly   330 LIAFVLLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRR------LEAFMHRPE 388
            .:..||.||.|.|..||.....|.::...:.| .|.|....||.:|::||      ||.:...|.
 Worm   391 FVGVVLAGNDLLASDAFSAITVYFVMLFGIRM-IPYGSRYLAEAVVAMRRIQEYLLLEQYAPYPV 454

  Fly   389 TKVRD-----KSKVKNANQKAESPNGDSPKGNGIPENLIEFSQFQARWESHSLEPTLEDI----- 443
            |...|     :........||.....|..|                       |||..::
 Worm   455 TNAEDVVLDCQGATYTYQPKAAKAPVDETK-----------------------EPTENEVIVVET 496

  Fly   444 --------NLQLGRRKLVAVIGPVGAGKSSLIQAILGELPGESGTLRINGSYS-YAAQEPWLFTG 499
                    .|.:.|.:.:||||.||.|||::::||.|.:......|.::.|.: |..|:.|:|.|
 Worm   497 PVFTCSFDKLSIKRGEHIAVIGAVGCGKSAILKAISGHMFTTDDALSVDRSQTVYVPQKAWIFNG 561

  Fly   500 TVRQNILFGLDWDKHRYRTVVKKCALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRR 564
            ||:.|||||...:..||...|..|.|..|...|..||:|.||||||:||||||||::|||||::.
 Worm   562 TVQDNILFGDKMNSERYYKAVNGCQLTEDLTTLSVGDRTEVGERGATLSGGQKARVALARAVFQT 626

  Fly   565 ADIYLLDDPLSAVDTHVGRHLFDQCMRGYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTY 629
            .::||.||..:::|..|...:.::.::..|:.:.:::||:.::.|...|.::.::.|.|.|.|.:
 Worm   627 KNLYLFDDIFASLDKKVANKIHEEIIQKLLKKKALMMVTNNMELLHHFDRVLFVEGGNIVADGNH 691

  Fly   630 SSMKRSGLDFAQLLTAPNKDAEDLDEIDGAG---GDGLDLLNVPSLSRRGSKNSKPSTRN----- 686
            ..:......:...:.|    .|......||.   |||               .::|:..:
 Worm   692 DILYEKNDAYKTFVDA----CETYQATSGATSPCGDG---------------PAQPAPLDAEILR 737

  Fly   687 NSFTSLSSMAESMAQEASLQMQETRVEGKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSA- 750
            ||...|...|:.:..:     :|......|...:||:|:.:...|     .::.||....:.:.
 Worm   738 NSSEDLKGDADKLISD-----EEDMGNSTIAWRIYKQYIHAAGGW-----PIWTCLVIGFIVNVV 792

  Fly   751 ----ADYFLSYWVDKNVDGQTDINT-------------DPQDMYYFAALNVAVVVFTI---VRTM 795
                :.|:||.|:.|..|..|.|..             .|...:|.|...||:||.||   .:..
 Worm   793 SNIFSTYWLSRWLKKGHDETTTITNGTEFLEMKTSLADSPVTGFYAAVYLVALVVLTISGLFKAC 857

  Fly   796 LFYKMAMRSSTQLHNAMYQGITRAAMYFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLT 860
            :|.|:::.::|:||:.|:|.:...|..||::.|:||||||||||:.::|..||......:|..:|
 Worm   858 VFVKVSLTAATRLHDRMFQAVIHGATSFFDSTPTGRILNRFSKDMDEIDVKLPFTAEVFLQNMIT 922

  Fly   861 LLGIIVVICITNPYYLILTLALAIIFYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTI 925
            .||.:|||....||:|:..:.|.::|......:....|::||.|.::|||:|.|:||::.|:.||
 Worm   923 CLGFLVVITSVFPYFLLFAIPLFVVFVVFVSCFRAGIRNLKRSEHISRSPLYDHVSASLEGITTI 987

  Fly   926 RALGAQKELIAEFDNLQDLHSSGYYTFLATNRAFGYYLDCFCTLYIVII-ILNYFINPPQSPGEV 989
            .........:.......|.:|...:.|.:..|....:||....:...|: :|...:....||.:.
 Worm   988 HTFQQSNRFLEVLKKHLDCNSGAIFMFQSAMRWLAVWLDLLVVVMTAIVALLTVMLTGTVSPADA 1052

  Fly   990 GLAITQAMGMTGMVQWAMRQSAELENTMTAVERVVEY-DEIEPEGEFDSREGKKPSPSWPEKGEI 1053
            |:||..|:.|:|:.|:|:|...|||..||:||||..| |.|..:||:::|:|.....|||..|:|
 Worm  1053 GMAIAFAVQMSGIFQFAVRTQTELEAKMTSVERVSYYADNIPEDGEWNTRQGLDIESSWPANGQI 1117

  Fly  1054 IAEDLCLRYFPD-PQAKYVLKALNFRIRPCEKVGIVGRTGAGKSSLINALFRL-SYNEGIITIDE 1116
            ...::.|||... |.|   |..:.|.|:..|||||:||||:|||||.|.:||| ....|.|.||.
 Worm  1118 NFSEVNLRYRKSHPLA---LNDITFEIKGGEKVGIIGRTGSGKSSLANLIFRLYPVTNGTIYIDG 1179

  Fly  1117 RDTADMGLFDLRSKISIIPQEPVLFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQ 1181
            .|...:||..||..||.|.|:|.||||::|:||||..||:|:.:|:|||:..||.|:..|...|:
 Worm  1180 VDIRTVGLVKLRRGISAIAQDPSLFSGTVRFNLDPSLEYSDSMIWEALEKCHLKTLVQSLDKKLE 1244

  Fly  1182 SKISEGGSNFSVGQRQLVCLARAILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIA 1246
            :.:|.||:|||||:|||.|||||:|.::|::::|||||:||..||.|||..|::.|.|.||:.||
 Worm  1245 ADVSHGGNNFSVGERQLFCLARALLMKSRIVILDEATASVDAGTDKLIQEVIKTVFADATVIIIA 1309

  Fly  1247 HRLNTIMDSDRVLVMDAGHLVEFGSPYELLTSSESKIF---------HGMVMETGQNTFDSLLKV 1302
            |||:.:.:.||::.:..|.|:.|.:|.|:.....| ::         |..|: .|:|:..|:.|.
 Worm  1310 HRLDNVRNMDRIMHLKNGKLINFTTPQEMFKDDWS-VYKLEDKDDDQHSAVV-VGENSEHSMEKS 1372

  Fly  1303 AEKAHLES 1310
            ::.:..||
 Worm  1373 SQGSSQES 1380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	MRP_assoc_pro	13..1292	CDD:188098	421/1353 (31%)
mrp-5	NP_510479.1	MRP_assoc_pro	90..1340	CDD:188098	415/1316 (32%)