Protein Alignment Mrp4 and mrp-1

DIOPT Version :10

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: NP_508122.2
• Gene: mrp-1 / 180409
• WormBaseID: WBGene00003407
• Length: 1534
• Species: Caenorhabditis elegans
• Alignment Length: 1388
• Identity: 466/1388 - (33%)
• Similarity: 727/1388 - (52%)
• Gaps: 157/1388 - (11%)

  Fly     8 ELPEN--------PRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSL------- 57
            :.|.|        |...:|.|:.|.|.:...:.:.|.||:||::||:...:..|::::
 Worm   195 DTPSNGYIGKNSCPEYTASFLNQLTFQWFSGLAYLGNKKSLEKEDLWDLNERDKAENIIPSFIEN 259

  Fly    58 ------GDRLCAAWDEQVAKN-------ETPRLGRALTKVFGFHLFITGVFLLAQEFLTKVTQPI 109
                  |.|      .::.||       ..|.:...:.|.:.|.|...|.:.|..:.|..|. |.
 Worm   260 LIPEVEGYR------RKIKKNPEAAIPKNHPSILIPIFKTYKFTLLAGGCYKLMFDLLQFVA-PE 317

  Fly   110 CLIGVMAYFAG-NDPDRSKAQLWAAGLIA-----GSVFSVCIGHPYMLGLLHLGMKMRIALSSLI 168
            .|..::::... |.|      :|....||     .|:....|.|.|...:..|||.:|..|:|.:
 Worm   318 LLRQLISFIEDKNQP------MWIGVSIALLMFLSSLLQSMILHQYFHEMFRLGMNIRSVLTSAV 376

  Fly   169 YRKALRLSRTALGDTTVGQVVNLLSNDVGRFDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMF 233
            |.|.|.||..|....|.|.:|||:|.|:.|...:...:...|.|||:::...|.::..:|:|.:.
 Worm   377 YTKTLNLSNEARKGKTTGAIVNLMSVDIQRIQDMTTFIMLFWSAPLQILLSLYFLWKLLGVSVLA 441

  Fly   234 GVAIMLLFLPFQSYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRF 298
            |..|::|.:||.|::..:....::......|||::||:||::|::|:|:|:|||...|:|...|.
 Worm   442 GFVILILLIPFNSFISVKMRNCQMEQMKFKDERIKMMSEILNGMKVLKLYSWEKSMEKMVLEVRE 506

  Fly   299 NEMLCIKQVNYIR-GILISFAM--FLSRIFTSSSLIAFVLLGNILNAEKAFFVTAYYNILRRSVT 360
            .|:..:|:::|:. ...:|:|.  ||..:.|....:.:....|:|..:..|...|.:||||..:.
 Worm   507 KEIRVLKKLSYLNAATTLSWACAPFLVAVLTFGLYVLWDPENNVLTPQITFVALALFNILRFPLA 571

  Fly   361 MF---FPQGISEFAELLVSVRRLEAFMHRPETKVRDKSKVKNANQKAESPNGDSPKGNGIPENLI 422
            :|   |.|.:    :...|..||:.|.                  .||..:..:....|..::.|
 Worm   572 VFAMVFSQAV----QCSASNTRLKEFF------------------AAEEMSPQTSIAYGGTDSAI 614

  Fly   423 EFSQFQARWESHSLEPTLEDINLQLGRRKLVAVIGPVGAGKSSLIQAILGELPGESGTLRINGSY 487
            :.......|.|...:..|.||...:.|.:|||::|.||:|||||:.|:|||:...||::::|||.
 Worm   615 KMDGGSFAWGSKEEDRKLHDITFNIKRGQLVAIVGRVGSGKSSLLHALLGEMNKLSGSVQVNGSV 679

  Fly   488 SYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCALERDFELLPFGDKTIVGERGASLSGGQK 552
            :|..|..|:...::|.||||...:|...|:.|::.|||.:|.|.||..|:|.:||:|.:||||||
 Worm   680 AYVPQLAWIQNLSLRNNILFNRPYDAKLYQNVIENCALVQDLESLPAEDRTEIGEKGINLSGGQK 744

  Fly   553 ARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFDQCM---RGYLRSELVILVTHQLQFLEQADL 614
            .|:|||||||:.|:|.||||||||||:|||:|:|:..:   .|.|.::..:|:||.|.:|:..|.
 Worm   745 QRVSLARAVYQNAEIVLLDDPLSAVDSHVGKHIFENVISTATGCLGTKTRVLLTHGLTYLKHCDQ 809

  Fly   615 IVIMDKGRISAMGTYSSMKRSGLDFAQLL---------------------TAPNKDAEDLDEIDG 658
            ::::....||.||||..:..|...|::.|                     ...|:...|||::..
 Worm   810 VIVLKDETISEMGTYQELMNSNGAFSEFLEEFLLEESKHKGRSVSFGEDSKEVNELLRDLDQVSP 874

  Fly   659 AGGDGLDLLNVPSLSRRGSKNS---KPSTRNNSFTSLSSMAESMAQEASL--------------- 705
            |....:.......:.:...||:   :.....:..|:.||:.:|..:|:.|
 Worm   875 AIRQRIQSQMSQEIEKTDDKNAEIIRNGLHKDEQTAHSSIGKSEEKESLLGAISPKEKTPEPPKQ 939

  Fly   706 ----QMQETRVE-GKIGLGLYKEYLTS-GSSWFMIFFMVFLCLATQILCSAADYFLSYWVD--KN 762
                .:::..|| ||:...:|..|..: |....::||:|:  :|:.:|...::.:|:.|.|  |.
 Worm   940 TKTQLIEKEAVETGKVKFEVYMSYFRAIGIKIALVFFLVY--VASSMLGVFSNLYLARWSDDAKE 1002

  Fly   763 V-------DGQTDINTDPQDMYYFAALNVAVVVFTIVRTMLFYKMAMRSSTQLHNAMYQGITRAA 820
            :       ..:|.|.     :..:|.|.:.........:::.....:.:|..||..:.:.|.|:.
 Worm  1003 IALSGNGSSSETQIR-----LGIYAVLGMGQATSVCAASIIMALGMVCASRLLHATLLENIMRSP 1062

  Fly   821 MYFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLILTLALAII 885
            |.||:..|.|||||||.||:..:|..|||.::..|...:..:.|..|.....|........:.|.
 Worm  1063 MAFFDVTPLGRILNRFGKDIDVIDYRLPSCIMTFVGAIVQAVTIFAVPIYATPLSSFPITIVLIG 1127

  Fly   886 FYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSSGYY 950
            :|::..||:.|||.:||||:.:|||||||...:|.|..:|||.|...:.|.|..:..|.:.:.||
 Worm  1128 YYFLLRFYVSTSRQLKRLESASRSPIYSHFQESIQGASSIRAYGVVDKFIRESQHRVDENLATYY 1192

  Fly   951 TFLATNRAFGYYLDCFCTLYIVIIILN------YFINPP-QSPGEVGLAITQAMGMTGMVQWAMR 1008
            ..:..||.....|:....|    |:|:      ||.:.| .|.|.|||:::.|:.:|..:.||:|
 Worm  1193 PSIVANRWLAVRLEMVGNL----IVLSSAGAAVYFRDSPGLSAGLVGLSVSYALNITQTLNWAVR 1253

  Fly  1009 QSAELENTMTAVERVVEYDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYVLK 1073
            .::|||..:.||||:.||.....||  ::.:...|. ||||.|||..::..:||  .|....||.
 Worm  1254 MTSELETNIVAVERINEYTITPTEG--NNSQSLAPK-SWPENGEISIKNFSVRY--RPGLDLVLH 1313

  Fly  1074 ALNFRIRPCEKVGIVGRTGAGKSSLINALFR-LSYNEGIITIDERDTADMGLFDLRSKISIIPQE 1137
            .:...|.||||:|||||||||||||..|||| :..:.|.|.||..:.||:.|..|||:::|:||:
 Worm  1314 GVTAHISPCEKIGIVGRTGAGKSSLTLALFRIIEADGGCIEIDGTNIADLLLEQLRSRLTIVPQD 1378

  Fly  1138 PVLFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLA 1202
            ||||||:||.|||||..::|.::|:||....|...:..|..||...|||||.|.|||||||:|||
 Worm  1379 PVLFSGTMRMNLDPFFAFSDDQIWEALRNAHLDSFVKSLQEGLHHHISEGGENLSVGQRQLICLA 1443

  Fly  1203 RAILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLV 1267
            ||:||:.:|||:|||.|.||.:||:|:|.|||.:|:|||||||||||||:|||||:||:|.|.:.
 Worm  1444 RALLRKTKVLVLDEAAAAVDVETDSLLQKTIREQFKDCTVLTIAHRLNTVMDSDRLLVLDKGCVA 1508

  Fly  1268 EFGSPYELLTSSESKIFHGMVME 1290
            ||.:|.:||::.:. ||:.|..:
 Worm  1509 EFDTPKKLLSNPDG-IFYSMAKD 1530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	MRP_assoc_pro	13..1292	CDD:188098	464/1375 (34%)
mrp-1	NP_508122.2	MRP_assoc_pro	23..1531	CDD:188098	466/1388 (34%)