Protein Alignment Mrp4 and mrp-2

DIOPT Version :10

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: NP_508121.1
• Gene: mrp-2 / 180408
• WormBaseID: WBGene00003408
• Length: 1525
• Species: Caenorhabditis elegans
• Alignment Length: 1375
• Identity: 476/1375 - (34%)
• Similarity: 739/1375 - (53%)
• Gaps: 158/1375 - (11%)

  Fly    13 PRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAWDEQVAKNETPRL 77
            |...:|.::.|.|.:...:.:.|.||:||.:||:...:..|:::|        .....:|..||:
 Worm   208 PEYTASFINRLTFQWFTGLAYLGNKKSLENEDLWDLNEIDKAENL--------IPSFMQNLKPRI 264

  Fly    78 -----------GRALTK---VFGFHLFITGVFLLAQEFLTKVTQPICLIGVMAYFA--------G 120
                       ..||.|   .|...:|.|..:.|...|..|    :| ..::.:.|        |
 Worm   265 DEYHQNIKKDPSAALPKNHPSFVIPIFKTYKYTLLAGFFYK----LC-FDMLQFLAPQLLKQLIG 324

  Fly   121 NDPDRSKAQLWAAGLIAGSVF------SVCIGHPYMLGLLHLGMKMRIALSSLIYRKALRLSRTA 179
            ...|::: .:|....|.|.:|      |:.: |.|...:..|||.:|..|:|.:|.|||.||..|
 Worm   325 FIEDKNQ-PVWIGCSIVGIMFFSSFLQSMFL-HQYYHSMFRLGMHVRSVLTSAVYSKALNLSNEA 387

  Fly   180 LGDTTVGQVVNLLSNDVGRFDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLLFLPF 244
            ....|:|.:|||:|.|:.:...:...:...|.|||::....|.::..:|::::.|:.:::|.||.
 Worm   388 RKGKTIGAIVNLMSVDIQKIQDMAPTIMLFWSAPLQIFLSIYFLWKFLGVAALAGLVVLILALPV 452

  Fly   245 QSYLG-----KRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCI 304
            ...:.     .:|..::|:     |||::||:||::|::|:|:|:||:....:|...|..|:..:
 Worm   453 NGLIAIQMRKCQTEQMKLK-----DERIKMMSEILNGMKVLKLYSWERSMENMVLKIRERELHIL 512

  Fly   305 KQVNY-IRGILISF--AMFLSRIFTSSSLIAFVLL---GNILNAEKAFFVTAYYNILRRSVTMFF 363
            |:::| :..|:.|:  |.||:.:.   |.:.:|.|   .|:|..|..|...:.::|||..:.| .
 Worm   513 KKLSYFMAAIVFSWICAPFLASVI---SFVVYVYLDPENNVLTPEITFVALSLFDILRMPLAM-V 573

  Fly   364 PQGISEFAELLVSVRRLEAFMHRPETKVRDKSKVKNANQKAESPNGDSPKGNGIPENLIEFSQFQ 428
            .....|..:..||..||:.|.                  .||..:..:...:|..::.||.....
 Worm   574 AMVYGEAVQCSVSNTRLKEFF------------------AAEEMSPQTSISHGETDSAIEVENGL 620

  Fly   429 ARWESHSLEPTLEDINLQLGRRKLVAVIGPVGAGKSSLIQAILGELPGESGTLRINGSYSYAAQE 493
            ..|.|.. :|||.:|:.::.:.:|||::|.||:|||||:.|:|||:...||:::|||:.:|..|:
 Worm   621 FSWSSDE-DPTLREISFKIQKGQLVAIVGKVGSGKSSLLHALLGEMNKLSGSVQINGNIAYVPQQ 684

  Fly   494 PWLFTGTVRQNILFGLDWDKHRYRTVVKKCALERDFELLPFGDKTIVGERGASLSGGQKARISLA 558
            .|:...::|.||||...:|...|..|||.|||:.|...||.||:|.:||:|.:||||||.|:|||
 Worm   685 AWIQNMSLRNNILFNKPYDLENYEDVVKNCALKEDLANLPAGDRTEIGEKGINLSGGQKQRVSLA 749

  Fly   559 RAVYRRADIYLLDDPLSAVDTHVGRHLFDQCM---RGYLRSELVILVTHQLQFLEQADLIVIMDK 620
            ||||:..||.||||||||||:|||:|:|:..:   .|.|.|:..:||||.|.:|:..|.::::.:
 Worm   750 RAVYQNPDIILLDDPLSAVDSHVGKHIFENVISSSTGCLASKTRVLVTHGLTYLKHCDQLIVLKE 814

  Fly   621 GRISAMGTYSSMKRSGLDFAQLLTAPNKDAED--LDEIDGAG-----GDG--------LDLLNV- 669
            |.||.:|||..:..:...||:.|       |:  ::|....|     |||        .||..|
 Worm   815 GTISELGTYQELLNNSGAFAEFL-------EEFLIEESKTRGRVASIGDGSGEVDEILRDLGQVK 872

  Fly   670 PSLSRR-----GSKNSKPST--------RNNSFTS----------------LSSMAESMAQEASL 705
            |.:.:|     ..::.|..|        |::|..|                |.:::|.:..:.:.
 Worm   873 PGILKRLESHLSQESDKEDTSARAIEYSRDSSRRSVLLHSPRSQHEENEALLGAISEDVPAQENT 937

  Fly   706 QM--QETRVEGKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSAADYFLSYWVDKNVDGQTD 768
            |:  :||...||:...:|..|..:.|....:.|. ||.:.:..|...::::|:...|....|...
 Worm   938 QLIEKETVETGKVKFEVYIAYFQAISIPITLLFF-FLYVGSSGLGILSNFYLAKLSDHAKSGNRT 1001

  Fly   769 INTDPQDMYYFAALNVAVVVFTIVRTMLFYKMAMRSSTQLHNAMYQGITRAAMYFFNTNPSGRIL 833
            .:....::..:|.|.:......::.:::.....:|:|..||..:...|.|:.|.||:..|.||||
 Worm  1002 SSDAKMELGIYAVLGMGQSFVVLIASIILTIGVLRASRILHAGLLGNIMRSPMAFFDVTPIGRIL 1066

  Fly   834 NRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLILTLALAIIFYYIREFYLKTSR 898
            ||..||:..:|..||.|:..:......::..:|||....|:..|....|::|::.:..||:.|||
 Worm  1067 NRIGKDIEAIDRTLPDVIRHMSMTIFNVVATLVVIMWATPWAGIAFAILSVIYFIVLRFYISTSR 1131

  Fly   899 DVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSSGYYTFLATNRAFGYYL 963
            .:||||:.:|||||||...:|.|..:|||.|.....|.:.....|.|...||..:..||.....|
 Worm  1132 QLKRLESASRSPIYSHFQESIQGASSIRAFGVVDNFIKQSQQRVDDHLIAYYPSIVANRWLAVRL 1196

  Fly   964 DCFCTLYIVIIILN------YFINPP-QSPGEVGLAITQAMGMTGMVQWAMRQSAELENTMTAVE 1021
            :....|    |:|:      ||.:.| .|.|.|||:::.|:.:|..:.||:|.::|||..:.:||
 Worm  1197 EMVGNL----IVLSAAGAAVYFRDSPGLSAGLVGLSVSYALNITQTLNWAVRMTSELETNIVSVE 1257

  Fly  1022 RVVEYDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYVLKALNFRIRPCEKVG 1086
            |:.||.....||....|...|   ||||||||..::..:||  .|....||..::..|.|.||||
 Worm  1258 RIKEYTVTPTEGNNSRRLAAK---SWPEKGEISIKNFSVRY--RPGLDLVLHGISAHIAPSEKVG 1317

  Fly  1087 IVGRTGAGKSSLINALFR-LSYNEGIITIDERDTADMGLFDLRSKISIIPQEPVLFSGSMRYNLD 1150
            ||||||||||||..|||| :..:.|.|.||..:.|::.|..|||.::|:||:||||||:|:.|||
 Worm  1318 IVGRTGAGKSSLTLALFRIIEADGGSIEIDGINIANLQLEQLRSCLTIVPQDPVLFSGTMKMNLD 1382

  Fly  1151 PFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARAILRENRVLVMD 1215
            ||..|:|:::|:|||...|||.:..|.:||:.||||||.|.|||||||:|||||:||:.:|||:|
 Worm  1383 PFSAYSDSQVWEALENAHLKPFVKSLQDGLEHKISEGGENLSVGQRQLICLARALLRKTKVLVLD 1447

  Fly  1216 EATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYELLTSSE 1280
            ||.|.||.:||:|||.|||.:|::||||||||||||:|||||:||:|.|.:.||.||..||.:.:
 Worm  1448 EAAAAVDVETDSLIQKTIREQFKECTVLTIAHRLNTVMDSDRLLVLDKGRVAEFDSPKNLLANPD 1512

  Fly  1281 SKIFHGMVME 1290
            . ||:.|..:
 Worm  1513 G-IFYSMAKD 1521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	MRP_assoc_pro	13..1292	CDD:188098	476/1375 (35%)
mrp-2	NP_508121.1	MRP_assoc_pro	25..1522	CDD:188098	476/1375 (35%)